(5 nodes) Brix domain network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ppan	Suppressor of SWI4 1 homolog; May have a role in cell growth. (470 aa)
	Brix1	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (353 aa)
	Rpf1	Ribosome production factor 1; May be required for ribosome biogenesis. (349 aa)
	Rpf2	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. (306 aa)
	Imp4	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). (291 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brix1	Imp4	ENSMUSP00000022855	ENSMUSP00000027303	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	0.961
Brix1	Ppan	ENSMUSP00000022855	ENSMUSP00000004203	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	Suppressor of SWI4 1 homolog; May have a role in cell growth.	0.928
Brix1	Rpf1	ENSMUSP00000022855	ENSMUSP00000029838	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	Ribosome production factor 1; May be required for ribosome biogenesis.	0.997
Brix1	Rpf2	ENSMUSP00000022855	ENSMUSP00000138581	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	0.991
Imp4	Brix1	ENSMUSP00000027303	ENSMUSP00000022855	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.961
Imp4	Ppan	ENSMUSP00000027303	ENSMUSP00000004203	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	Suppressor of SWI4 1 homolog; May have a role in cell growth.	0.903
Imp4	Rpf1	ENSMUSP00000027303	ENSMUSP00000029838	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	Ribosome production factor 1; May be required for ribosome biogenesis.	0.906
Imp4	Rpf2	ENSMUSP00000027303	ENSMUSP00000138581	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	0.958
Ppan	Brix1	ENSMUSP00000004203	ENSMUSP00000022855	Suppressor of SWI4 1 homolog; May have a role in cell growth.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.928
Ppan	Imp4	ENSMUSP00000004203	ENSMUSP00000027303	Suppressor of SWI4 1 homolog; May have a role in cell growth.	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	0.903
Ppan	Rpf1	ENSMUSP00000004203	ENSMUSP00000029838	Suppressor of SWI4 1 homolog; May have a role in cell growth.	Ribosome production factor 1; May be required for ribosome biogenesis.	0.987
Ppan	Rpf2	ENSMUSP00000004203	ENSMUSP00000138581	Suppressor of SWI4 1 homolog; May have a role in cell growth.	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	0.956
Rpf1	Brix1	ENSMUSP00000029838	ENSMUSP00000022855	Ribosome production factor 1; May be required for ribosome biogenesis.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.997
Rpf1	Imp4	ENSMUSP00000029838	ENSMUSP00000027303	Ribosome production factor 1; May be required for ribosome biogenesis.	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	0.906
Rpf1	Ppan	ENSMUSP00000029838	ENSMUSP00000004203	Ribosome production factor 1; May be required for ribosome biogenesis.	Suppressor of SWI4 1 homolog; May have a role in cell growth.	0.987
Rpf1	Rpf2	ENSMUSP00000029838	ENSMUSP00000138581	Ribosome production factor 1; May be required for ribosome biogenesis.	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	0.986
Rpf2	Brix1	ENSMUSP00000138581	ENSMUSP00000022855	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.991
Rpf2	Imp4	ENSMUSP00000138581	ENSMUSP00000027303	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).	0.958
Rpf2	Ppan	ENSMUSP00000138581	ENSMUSP00000004203	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	Suppressor of SWI4 1 homolog; May have a role in cell growth.	0.956
Rpf2	Rpf1	ENSMUSP00000138581	ENSMUSP00000029838	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.	Ribosome production factor 1; May be required for ribosome biogenesis.	0.986