(6 nodes) PapD-like superfamily network (Mus musculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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gene neighborhood

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protein homology

Your Input:
	Mospd1	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. (214 aa)
	Vapb	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (243 aa)
	Hydin	Hydrocephalus-inducing protein; Required for ciliary motility. (5154 aa)
	Mospd3	Motile sperm domain-containing protein 3. (235 aa)
	Vapa	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. (249 aa)
	Mospd2	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. (518 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mospd1	Mospd2	ENSMUSP00000023836	ENSMUSP00000004715	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	0.741
Mospd1	Vapa	ENSMUSP00000023836	ENSMUSP00000024897	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	0.526
Mospd1	Vapb	ENSMUSP00000023836	ENSMUSP00000064699	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	0.405
Mospd2	Mospd1	ENSMUSP00000004715	ENSMUSP00000023836	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	0.741
Mospd2	Mospd3	ENSMUSP00000004715	ENSMUSP00000040828	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	Motile sperm domain-containing protein 3.	0.688
Mospd2	Vapa	ENSMUSP00000004715	ENSMUSP00000024897	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	0.490
Mospd2	Vapb	ENSMUSP00000004715	ENSMUSP00000064699	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	0.473
Mospd3	Mospd2	ENSMUSP00000040828	ENSMUSP00000004715	Motile sperm domain-containing protein 3.	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	0.688
Mospd3	Vapa	ENSMUSP00000040828	ENSMUSP00000024897	Motile sperm domain-containing protein 3.	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	0.489
Vapa	Mospd1	ENSMUSP00000024897	ENSMUSP00000023836	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	0.526
Vapa	Mospd2	ENSMUSP00000024897	ENSMUSP00000004715	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	0.490
Vapa	Mospd3	ENSMUSP00000024897	ENSMUSP00000040828	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Motile sperm domain-containing protein 3.	0.489
Vapa	Vapb	ENSMUSP00000024897	ENSMUSP00000064699	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	0.981
Vapb	Mospd1	ENSMUSP00000064699	ENSMUSP00000023836	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	0.405
Vapb	Mospd2	ENSMUSP00000064699	ENSMUSP00000004715	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	0.473
Vapb	Vapa	ENSMUSP00000064699	ENSMUSP00000024897	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	0.981