(20 nodes) Cathepsin propeptide inhibitor domain (I29) network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ctsll3	Cathepsin L-like 3; Belongs to the peptidase C1 family. (331 aa)
	Ctsk	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family. (329 aa)
	Ctss	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. (341 aa)
	Ctla2a	Protein CTLA-2-alpha; Not known, expressed in activated T-cell; To the propeptide regions of cysteine proteases. (137 aa)
	Ctla2b	Protein CTLA-2-beta; Not known, expressed in activated T-cell. (113 aa)
	Ctsq	Cathepsin Q; Belongs to the peptidase C1 family. (343 aa)
	Ctsr	Cathepsin R. (334 aa)
	Cts6	Cathepsin-6; Belongs to the peptidase C1 family. (334 aa)
	Cts8	Cathepsin 8; Probable protease (By similarity). In placenta, plays a role in promoting giant cell differentiation. Also plays a role in placental spiral artery remodeling by direct degradation of smooth muscle alpha-actin. Belongs to the peptidase C1 family. (333 aa)
	Cts7	Cathepsin 7; Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression; Belongs to the peptidase C1 family. (331 aa)
	Ctsw	Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. (371 aa)
	BC051665	cDNA sequence BC051665; Belongs to the peptidase C1 family. (330 aa)
	Ctsh	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (333 aa)
	Gm49391	Predicted gene, 49391. (136 aa)
	Ctsm	Cathepsin M. (333 aa)
	Ctsl	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (334 aa)
	Ctsf	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. (462 aa)
	4930486L24Rik	Testin-1; Belongs to the peptidase C1 family. (333 aa)
	Ctsj	Cathepsin J; Belongs to the peptidase C1 family. (333 aa)
	Cts3	Cts3 protein; Belongs to the peptidase C1 family. (332 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ctla2a	Ctla2b	ENSMUSP00000021880	ENSMUSP00000021884	Protein CTLA-2-alpha; Not known, expressed in activated T-cell; To the propeptide regions of cysteine proteases.	Protein CTLA-2-beta; Not known, expressed in activated T-cell.	0.982
Ctla2b	Ctla2a	ENSMUSP00000021884	ENSMUSP00000021880	Protein CTLA-2-beta; Not known, expressed in activated T-cell.	Protein CTLA-2-alpha; Not known, expressed in activated T-cell; To the propeptide regions of cysteine proteases.	0.982
Cts3	Ctsm	ENSMUSP00000058359	ENSMUSP00000153101	Cts3 protein; Belongs to the peptidase C1 family.	Cathepsin M.	0.680
Ctsf	Ctsk	ENSMUSP00000112481	ENSMUSP00000015664	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family.	0.486
Ctsf	Ctsl	ENSMUSP00000112481	ENSMUSP00000152169	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	0.568
Ctsh	Ctss	ENSMUSP00000034915	ENSMUSP00000015667	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.402
Ctsj	Ctsq	ENSMUSP00000071457	ENSMUSP00000021888	Cathepsin J; Belongs to the peptidase C1 family.	Cathepsin Q; Belongs to the peptidase C1 family.	0.411
Ctsj	Ctsr	ENSMUSP00000071457	ENSMUSP00000021889	Cathepsin J; Belongs to the peptidase C1 family.	Cathepsin R.	0.812
Ctsk	Ctsf	ENSMUSP00000015664	ENSMUSP00000112481	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family.	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	0.486
Ctsk	Ctsl	ENSMUSP00000015664	ENSMUSP00000152169	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	0.744
Ctsk	Ctss	ENSMUSP00000015664	ENSMUSP00000015667	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.461
Ctsl	Ctsf	ENSMUSP00000152169	ENSMUSP00000112481	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	0.568
Ctsl	Ctsk	ENSMUSP00000152169	ENSMUSP00000015664	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family.	0.744
Ctsl	Ctss	ENSMUSP00000152169	ENSMUSP00000015667	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.920
Ctsl	Ctsw	ENSMUSP00000152169	ENSMUSP00000025844	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family.	Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family.	0.501
Ctsm	Cts3	ENSMUSP00000153101	ENSMUSP00000058359	Cathepsin M.	Cts3 protein; Belongs to the peptidase C1 family.	0.680
Ctsq	Ctsj	ENSMUSP00000021888	ENSMUSP00000071457	Cathepsin Q; Belongs to the peptidase C1 family.	Cathepsin J; Belongs to the peptidase C1 family.	0.411
Ctsq	Ctsr	ENSMUSP00000021888	ENSMUSP00000021889	Cathepsin Q; Belongs to the peptidase C1 family.	Cathepsin R.	0.406
Ctsr	Ctsj	ENSMUSP00000021889	ENSMUSP00000071457	Cathepsin R.	Cathepsin J; Belongs to the peptidase C1 family.	0.812
Ctsr	Ctsq	ENSMUSP00000021889	ENSMUSP00000021888	Cathepsin R.	Cathepsin Q; Belongs to the peptidase C1 family.	0.406