STRINGSTRING
Slurp1 Slurp1 Plaur Plaur Pinlyp Pinlyp Gpihbp1 Gpihbp1 Ly6f Ly6f Ly6i Ly6i Lynx1 Lynx1 Lypd2 Lypd2 Psca Psca Lypd5 Lypd5 Acrv1 Acrv1 Ly6d Ly6d Slurp2 Slurp2 Ly6k Ly6k Lypd10 Lypd10 Ly6g2 Ly6g2 Ly6e Ly6e Lypd9 Lypd9 Cd177 Cd177 Ly6m Ly6m Tex101 Tex101 Lypd4 Lypd4 Lypd3 Lypd3 Lypd11 Lypd11 Cd59b Cd59b Spaca4 Spaca4 Gml2 Gml2 Gml Gml Ly6c2 Ly6c2 2210407C18Rik 2210407C18Rik Lypd8 Lypd8 Ly6h Ly6h Cd59a Cd59a Ly6l Ly6l Ly6c1 Ly6c1 Ly6g Ly6g Ly6a Ly6a Ly6g6g Ly6g6g
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Slurp1Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7- dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have a immunom [...] (110 aa)
PlaurUrokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. (327 aa)
PinlypPhospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein. (212 aa)
Gpihbp1Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries. Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. Binds chylomicrons and phospholipid particles that contain APOA5. Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. (228 aa)
Ly6fLymphocyte antigen 6F. (134 aa)
Ly6iLymphocyte antigen 6I. (134 aa)
Lynx1Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] (116 aa)
Lypd2Ly6/PLAUR domain-containing protein 2. (127 aa)
PscaProstate stem cell antigen; May be involved in the regulation of cell proliferation. (123 aa)
Lypd5Ly6/PLAUR domain-containing protein 5. (256 aa)
Acrv1Acrosomal protein SP-10. (261 aa)
Ly6dLymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. (127 aa)
Slurp2Secreted Ly-6/uPAR domain-containing protein 2; Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7- containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha- 3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CH [...] (97 aa)
Ly6kLymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth (By similarity). (154 aa)
Lypd10Ly6/PLAUR domain-containing 10. (246 aa)
Ly6g2Lymphocyte antigen 6 complex, locus G2. (124 aa)
Ly6eLymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. (136 aa)
Lypd9LY6/PLAUR domain-containing 9. (145 aa)
Cd177CD177 antigen; In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (By similarity). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (By similarity). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (By similarity). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. [...] (817 aa)
Ly6mLymphocyte antigen 6 complex, locus M. (111 aa)
Tex101Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct probably through molecule adhesion ADAM3. May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). (250 aa)
Lypd4Ly6/PLAUR domain-containing protein 4. (246 aa)
Lypd3Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity). (363 aa)
Lypd11Ly6/PLAUR domain-containing 11. (196 aa)
Cd59bCD59B glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). (129 aa)
Spaca4Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Belongs to the SPACA4/bouncer family. (127 aa)
Gml2Glycosylphosphatidylinositol-anchored molecule-like 2. (176 aa)
GmlGlycosylphosphatidylinositol-anchored molecule-like. (176 aa)
Ly6c2Lymphocyte antigen 6C2. (131 aa)
2210407C18RikRIKEN cDNA 2210407C18 gene. (220 aa)
Lypd8Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis; Belongs to the CNF-like-inhibitor family. (255 aa)
Ly6hLymphocyte antigen 6H; Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity). (160 aa)
Cd59aCD59A glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). (123 aa)
Ly6lLymphocyte antigen 6L. (140 aa)
Ly6c1Lymphocyte antigen 6C1. (147 aa)
Ly6gLymphocyte antigen 6G. (134 aa)
Ly6aLymphocyte antigen 6A-2/6E-1; T-cell activation. (134 aa)
Ly6g6gLymphocyte antigen 6 complex, locus G6G. (115 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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