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| | Prss8 | Prostasin heavy chain; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates (By similarity). Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G); Belongs to the peptidase S1 family. (339 aa) |
| | Tmprss2 | Transmembrane protease serine 2 non-catalytic chain; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. The spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spik [...] (490 aa) |
| | Klk9 | Kallikrein-related-peptidase 9; Belongs to the peptidase S1 family. (251 aa) |
| | Klk1b16 | Kallikrein 1-related peptidase b16. (261 aa) |
| | Prtn3 | Myeloblastin; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177; Belongs to the peptidase S1 family. Elastase subfamily. (254 aa) |
| | Klk1b11 | Kallikrein 1-related peptidase b11; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Klk4 | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. (255 aa) |
| | Prss45 | Inactive serine protease 45; Belongs to the peptidase S1 family. (317 aa) |
| | Klk10 | Kallikrein-related-peptidase 10; Belongs to the peptidase S1 family. (278 aa) |
| | Plg | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (812 aa) |
| | Prss28 | Serine protease 28; Involved in embryo hatching and implantation. (274 aa) |
| | Mcpt2 | Mast cell protease 2. (244 aa) |
| | Gzmg | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Gzmb | Granzyme B(G,H); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). (247 aa) |
| | Ctsg | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. (261 aa) |
| | Gzmc | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Gzmn | Granzyme N; Belongs to the peptidase S1 family. (248 aa) |
| | Mcpt8 | Mast cell protease 8. (247 aa) |
| | Tmprss6 | Transmembrane protease serine 6; Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis. (811 aa) |
| | Gzmm | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. (264 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (597 aa) |
| | Prss52 | Serine protease 52; Probable serine protease; Belongs to the peptidase S1 family. (321 aa) |
| | Gzmf | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Cma1 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. (260 aa) |
| | Mcpt1 | Mast cell protease 1; Has a chymotrypsin-like activity. (246 aa) |
| | Acr | Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family. (436 aa) |
| | Tmprss15 | Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity). (1069 aa) |
| | Cela1 | Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (266 aa) |
| | Gzma | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). (260 aa) |
| | Cela3a | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. (283 aa) |
| | Prss41 | Serine protease 41; Belongs to the peptidase S1 family. (322 aa) |
| | Prss21 | Testisin; Could regulate proteolytic events associated with testicular germ cell maturation; Belongs to the peptidase S1 family. (324 aa) |
| | Prss29 | Serine protease 29; Involved in embryo hatching and implantation. Belongs to the peptidase S1 family. (279 aa) |
| | Tpsg1 | Tryptase gamma heavy chain; Belongs to the peptidase S1 family. Tryptase subfamily. (311 aa) |
| | Cfb | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. (763 aa) |
| | C2 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family. (760 aa) |
| | Klkb1 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. (638 aa) |
| | Prss39 | Inactive serine protease 39; May play an important role in the sperm/egg interaction; released during the acrosome reaction; Belongs to the peptidase S1 family. (367 aa) |
| | F2 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (618 aa) |
| | Prss12 | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. (761 aa) |
| | Hgfac | Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. (653 aa) |
| | Tmprss11d | Transmembrane protease serine 11D non-catalytic chain; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC; Belongs to the peptidase S1 family. (417 aa) |
| | Prss1 | Protease, serine, 1 (Trypsin 1); Belongs to the peptidase S1 family. (246 aa) |
| | Try4 | Pancreatic trypsin; Belongs to the peptidase S1 family. (246 aa) |
| | 2210010C04Rik | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. (247 aa) |
| | 1700074P13Rik | RIKEN cDNA 1700074P13 gene; Belongs to the peptidase S1 family. (251 aa) |
| | Klk7 | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. (249 aa) |
| | F9 | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (471 aa) |
| | F7 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). (446 aa) |
| | F10 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. (493 aa) |
| | Plat | Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events; Belongs to the peptidase S1 family. (559 aa) |
| | F11 | Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. (624 aa) |
| | Ctrl | Chymotrypsin A CTRA-1; Belongs to the peptidase S1 family. (264 aa) |
| | Ctrb1 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. (263 aa) |
| | St14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). (855 aa) |
| | Tmprss13 | Transmembrane protease serine 13. (548 aa) |
| | Tmprss4 | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC; Belongs to the peptidase S1 family. (435 aa) |
| | Prss35 | Inactive serine protease 35; Belongs to the peptidase S1 family. (409 aa) |
| | Mcpt4 | Mast cell protease 4; Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala- 5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. (246 aa) |
| | Hpn | Serine protease hepsin non-catalytic chain; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2 (By similarity). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization. (445 aa) |
| | Elane | Neutrophil elastase; Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli ; Belongs to the peptidase S1 family. Elastase subfamily. (265 aa) |
| | Gm5771 | Predicted gene, EG436523; Belongs to the peptidase S1 family. (245 aa) |
| | Prss22 | Brain-specific serine protease 4; Belongs to the peptidase S1 family. (307 aa) |
| | Ctrc | Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily. (267 aa) |
| | Prss42 | Serine protease 42; Plays a role in spermatogenesis. Involved in germ cell survival during meiosis; Belongs to the peptidase S1 family. (335 aa) |
| | Tmprss11b | Transmembrane protease serine 11B-like protein; Serine protease; Belongs to the peptidase S1 family. (416 aa) |
| | Gzmk | Granzyme K. (263 aa) |
| | Prss40 | Serine protease 40; May play an important role in the sperm/egg interaction; released during the acrosome reaction; Belongs to the peptidase S1 family. (365 aa) |
| | Prss23 | Serine protease 23. (382 aa) |
| | Prss34 | Mast cell protease-11; Belongs to the peptidase S1 family. (318 aa) |
| | Klk1b26 | Kallikrein 1-related peptidase b26; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (261 aa) |
| | Klk5 | Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. (293 aa) |
| | Prss32 | Protease, serine 32; Belongs to the peptidase S1 family. (334 aa) |
| | Prss48 | Serine protease 48. (312 aa) |
| | Prss38 | Serine protease 38. (322 aa) |
| | Prss27 | Serine protease 27. (328 aa) |
| | Cfd | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. (259 aa) |
| | Klk14 | Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...] (250 aa) |
| | Prss33 | Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. (277 aa) |
| | Tmprss11c | Transmembrane protease serine 11C non-catalytic chain; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. (431 aa) |
| | Try5 | Trypsinogen 9; Belongs to the peptidase S1 family. (246 aa) |
| | Tmprss5 | Transmembrane protease serine 5; May play a role in hearing. (445 aa) |
| | Klk13 | Kallikrein-related-peptidase 13; Belongs to the peptidase S1 family. (276 aa) |
| | Prss2 | Anionic trypsin-2. (246 aa) |
| | Klk15 | Kallikrein-related-peptidase 15; Belongs to the peptidase S1 family. (254 aa) |
| | Prss58 | Putative inactive serine protease 58; Belongs to the peptidase S1 family. (241 aa) |
| | Try10 | Trypsinogen 10; Belongs to the peptidase S1 family. (246 aa) |
| | Klk1b8 | Kallikrein 1-related peptidase b8; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Klk1b24 | Kallikrein 1-related peptidase b24; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (263 aa) |
| | Klk1b5 | Kallikrein 1-related peptidase b5; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Klk1 | Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | 1810009J06Rik | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. (247 aa) |
| | Klk1b4 | Kallikrein 1-related peptidase-like b4. (256 aa) |
| | Klk1b22 | Kallikrein 1-related peptidase b22; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (259 aa) |
| | Prss43 | Putative inactive serine protease 43; Plays a role in spermatogenesis. Involved in germ cell survival during meiosis; Belongs to the peptidase S1 family. (382 aa) |
| | Cfi | Complement factor I heavy chain; Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired [...] (603 aa) |
| | Klk1b1 | Kallikrein 1-related peptidase b1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Klk1b27 | Kallikrein 1-related peptidase b27; Serine protease with chymotrypsin-like cleavage specificity. Shows activity towards casein, gelatin, IGFBP3 and fibronectin but not towards laminin or collagens I and IV. Does not hydrolyze kininogin to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (263 aa) |
| | Klk11 | Kallikrein-11; Possible multifunctional protease. Efficiently cleaves 'bz- Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity). Belongs to the peptidase S1 family. Kallikrein subfamily. (276 aa) |
| | Klk1b9 | Kallikrein 1-related peptidase b9; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Gzmd | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (252 aa) |
| | Klk1b3 | Kallikrein 1-related peptidase b3; 7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts. (261 aa) |
| | Klk1b21 | Kallikrein 1-related peptidase b21; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa) |
| | Klk8 | Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] (260 aa) |
| | Gzme | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Cma2 | Mast cell protease 10; Belongs to the peptidase S1 family. (246 aa) |
| | Masp1 | Mannan-binding lectin serine protease 1 heavy chain; Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of [...] (704 aa) |
| | Mcpt9 | Mast cell protease 9. (246 aa) |
| | Habp2 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. (517 aa) |
| | Gm10334 | Predicted gene 10334; Belongs to the peptidase S1 family. (246 aa) |
| | Prss3 | Protease, serine 3; Belongs to the peptidase S1 family. (246 aa) |
| | Tmprss12 | Transmembrane protease serine 12. (336 aa) |
| | Prss44 | Serine protease 44; Belongs to the peptidase S1 family. (372 aa) |
| | Tmprss11a | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest; Belongs to the peptidase S1 family. (389 aa) |
| | Cela2a | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (271 aa) |
| | Cela3b | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. (269 aa) |
| | Ovch2 | Ovochymase-2; Belongs to the peptidase S1 family. (609 aa) |
| | Klk6 | Kallikrein-related-peptidase 6; Belongs to the peptidase S1 family. (253 aa) |
| | Klk12 | Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family. (247 aa) |
| | Tmprss3 | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). (475 aa) |
| | Tmprss7 | Transmembrane protease serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position; Belongs to the peptidase S1 family. (829 aa) |
| | Tmprss11f | Transmembrane protease serine 11F; Probable serine protease; Belongs to the peptidase S1 family. (439 aa) |
| | Prss36 | Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg- AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala- Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity); Belongs to the peptidase S1 family. (852 aa) |
| | Prss53 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Belongs to the peptidase S1 family. (552 aa) |
| | Gm20547 | Predicted gene 20547; Belongs to the peptidase S1 family. (1276 aa) |
| | Tpsab1 | Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily. (310 aa) |
| | Tmprss11e | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Belongs to the peptidase S1 family. (423 aa) |
| | Gm2663 | Predicted gene 2663; Belongs to the peptidase S1 family. (247 aa) |
| | Prss57 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues; Belongs to the peptidase S1 family. (284 aa) |
| | Prss46 | Serine protease 46; Belongs to the peptidase S1 family. (314 aa) |
| | Prss56 | Serine protease 56; Serine protease required during eye development. (604 aa) |
| | Tmprss9 | Transmembrane protease serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity). (1099 aa) |
| | Prss30 | Serine protease 30; Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC (By similarity). Belongs to the peptidase S1 family. (310 aa) |
| | Proc | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (460 aa) |
| | Tpsb2 | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity. (276 aa) |
