STRINGSTRING
Serpina3n Serpina3n Serpinf1 Serpinf1 Serpinb9b Serpinb9b Serpinb1b Serpinb1b Serpinb6a Serpinb6a Serpina1f Serpina1f Serpina5 Serpina5 Serpinb1c Serpinb1c Serpinb9c Serpinb9c Serpind1 Serpind1 Serpinb3d Serpinb3d Serping1 Serping1 Serpine2 Serpine2 Serpinb13 Serpinb13 Serpinb3c Serpinb3c Serpinb11 Serpinb11 Serpinb3a Serpinb3a Serpini1 Serpini1 Serpina7 Serpina7 Serpine1 Serpine1 Serpina3g Serpina3g Serpina3k Serpina3k Serpina6 Serpina6 Serpina12 Serpina12 Serpini2 Serpini2 Serpina10 Serpina10 Serpinf2 Serpinf2 Serpinb9h Serpinb9h Serpina9 Serpina9 Serpinb6d Serpinb6d Serpinb2 Serpinb2 Agt Agt Serpinb9d Serpinb9d Serpinc1 Serpinc1 Serpinb9e Serpinb9e Serpina1a Serpina1a Serpina1c Serpina1c Serpina11 Serpina11 Serpinb9f Serpinb9f Serpinb1a Serpinb1a Serpina1d Serpina1d Serpinb12 Serpinb12 Serpinb9g Serpinb9g Serpina3c Serpina3c Serpina3b Serpina3b Serpinb7 Serpinb7 Serpinb3b Serpinb3b Serpinb9 Serpinb9 Serpina3j Serpina3j Serpina3i Serpina3i Serpinb6e Serpinb6e Serpinb6b Serpinb6b Serpinb8 Serpinb8 Serpinb5 Serpinb5 Serpina1e Serpina1e Serpina3f Serpina3f Serpine3 Serpine3 Serpinh1 Serpinh1 Serpina16 Serpina16 Serpinb6c Serpinb6c Serpina3m Serpina3m Serpina1b Serpina1b Serpina3a Serpina3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Serpina3nSerine protease inhibitor A3N. (418 aa)
Serpinf1Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. (417 aa)
Serpinb9bSerine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. (377 aa)
Serpinb1bLeukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. (382 aa)
Serpinb6aSerpin B6; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. (399 aa)
Serpina1fAlpha-1-antitrypsin 1-6; Inhibitor of serine proteases. Belongs to the serpin family. (411 aa)
Serpina5Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] (405 aa)
Serpinb1cLeukocyte elastase inhibitor C; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (By similarity). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. (375 aa)
Serpinb9cSerine (or cysteine) peptidase inhibitor, clade B, member 9c; Belongs to the serpin family. (387 aa)
Serpind1Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan- independent manner; Belongs to the serpin family. (478 aa)
Serpinb3dSerine (Or cysteine) peptidase inhibitor, clade B (Ovalbumin), member 3D; Belongs to the serpin family. (387 aa)
Serping1Plasma protease C1 inhibitor; Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein. (504 aa)
Serpine2Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. (397 aa)
Serpinb13Serpin B13; May play a role in the proliferation or differentiation of keratinocytes. (389 aa)
Serpinb3cSerine (Or cysteine) peptidase inhibitor, clade B, member 3C; Belongs to the serpin family. (386 aa)
Serpinb11Serpin B11; Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma. (388 aa)
Serpinb3aSerine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; Belongs to the serpin family. (387 aa)
Serpini1Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). (410 aa)
Serpina7Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. (426 aa)
Serpine1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] (402 aa)
Serpina3gSerine protease inhibitor A3G; Belongs to the serpin family. (248 aa)
Serpina3kSerine protease inhibitor A3K; Contrapsin inhibits trypsin-like proteases. (418 aa)
Serpina6Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species; Belongs to the serpin family. (397 aa)
Serpina12Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. (413 aa)
Serpini2Serpin I2; Belongs to the serpin family. (405 aa)
Serpina10Protein Z-dependent protease inhibitor; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity). (448 aa)
Serpinf2Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin (By similarity). (491 aa)
Serpinb9hSerine (or cysteine) peptidase inhibitor, clade B, member 9h; Belongs to the serpin family. (377 aa)
Serpina9Serpin A9. (418 aa)
Serpinb6dSerine (or cysteine) peptidase inhibitor, clade B, member 6d; Belongs to the serpin family. (375 aa)
Serpinb2Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. (415 aa)
AgtAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (482 aa)
Serpinb9dSerine (Or cysteine) peptidase inhibitor, clade B, member 9D; Belongs to the serpin family. (377 aa)
Serpinc1Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). (465 aa)
Serpinb9eSerine (Or cysteine) peptidase inhibitor, clade B, member 9e; Belongs to the serpin family. (377 aa)
Serpina1aAlpha-1-antitrypsin 1-1; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Belongs to the serpin family. (436 aa)
Serpina1cAlpha-1-antitrypsin 1-3; Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Belongs to the serpin family. (413 aa)
Serpina11Serpin A11. (427 aa)
Serpinb9fSerine (Or cysteine) peptidase inhibitor, clade B, member 9f; Belongs to the serpin family. (377 aa)
Serpinb1aLeukocyte elastase inhibitor A; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as [...] (379 aa)
Serpina1dAlpha-1-antitrypsin 1-4; Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Belongs to the serpin family. (413 aa)
Serpinb12Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. (423 aa)
Serpinb9gSerine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family. (377 aa)
Serpina3cSerine protease inhibitor A3C. (417 aa)
Serpina3bSerine protease inhibitor A3B. (420 aa)
Serpinb7Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity); Belongs to the serpin family. Ov-serpin subfamily. (380 aa)
Serpinb3bSerine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B; Belongs to the serpin family. (387 aa)
Serpinb9Serine (Or cysteine) peptidase inhibitor, clade B, member 9; Belongs to the serpin family. (374 aa)
Serpina3jSerine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J; Belongs to the serpin family. (420 aa)
Serpina3iSerine (or cysteine) peptidase inhibitor, clade A, member 3I; Belongs to the serpin family. (408 aa)
Serpinb6eSerine (or cysteine) peptidase inhibitor, clade B, member 6e; Belongs to the serpin family. (429 aa)
Serpinb6bSerine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. (377 aa)
Serpinb8Serpin B8; Has an important role in epithelial desmosome-mediated cell- cell adhesion; Belongs to the serpin family. Ov-serpin subfamily. (374 aa)
Serpinb5Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). (375 aa)
Serpina1eAlpha-1-antitrypsin 1-5; Does not inhibit elastase or chymotrypsin. No target protease has been identified to date; Belongs to the serpin family. (413 aa)
Serpina3fSerine protease inhibitor A3F; Belongs to the serpin family. (445 aa)
Serpine3Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Belongs to the serpin family. (401 aa)
Serpinh1Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. (417 aa)
Serpina16Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16; Belongs to the serpin family. (418 aa)
Serpinb6cSerine (or cysteine) peptidase inhibitor, clade B, member 6c; Belongs to the serpin family. (379 aa)
Serpina3mSerine protease inhibitor A3M; Belongs to the serpin family. (418 aa)
Serpina1bAlpha-1-antitrypsin 1-2; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Belongs to the serpin family. (413 aa)
Serpina3aSerine protease inhibitor A3A; Belongs to the serpin family. (422 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.