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Cst8 Cst8 Csta1 Csta1 Cstdc5 Cstdc5 Csta3 Csta3 Cst7 Cst7 Stfa2l1 Stfa2l1 Stfa3 Stfa3 Lxn Lxn Rarres1 Rarres1 Cst10 Cst10 Cst13 Cst13 Fetub Fetub Stfa1 Stfa1 Ngp Ngp Cst3 Cst3 Cstdc2 Cstdc2 Cst9 Cst9 Cst11 Cst11 Cstdc1 Cstdc1 Spp2 Spp2 Cst6 Cst6 Hrg Hrg Kng1 Kng1 Ahsg Ahsg Rarres2 Rarres2 Cstb Cstb Csta2 Csta2 Cst12 Cst12 Cstdc4 Cstdc4 Cstdc6 Cstdc6 Camp Camp Cstl1 Cstl1 Kng2 Kng2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cst8Cystatin-8; Performs a specialized role during sperm development and maturation; Belongs to the cystatin family. (142 aa)
Csta1Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. (97 aa)
Cstdc5Cystatin domain-containing 5. (97 aa)
Csta3Cystatin A family member 3. (97 aa)
Cst7Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. (144 aa)
Stfa2l1Stefin-2; This is an intracellular thiol proteinase inhibitor. (103 aa)
Stfa3Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (103 aa)
LxnLatexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. Belongs to the protease inhibitor I47 (latexin) family. (222 aa)
Rarres1Retinoic acid receptor responder (tazarotene-induced) 1. (283 aa)
Cst10Cystatin 10; May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation. Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification. Possibly impairs the binding of a transcription factor to the ENPP1 promoter. Unlike other cystatins, does not have thiol protease inhibitor activity. (148 aa)
Cst13Cystatin-13; May perform a specialized role during sperm development and maturation; Belongs to the cystatin family. (141 aa)
FetubFetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. Belongs to the fetuin family. (388 aa)
Stfa1Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (97 aa)
NgpNeutrophilic granule protein; Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis. (167 aa)
Cst3Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. (140 aa)
Cstdc2Cystatin domain-containing 2. (133 aa)
Cst9Cystatin-9; May be involved in testis development. May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria. (137 aa)
Cst11Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. (139 aa)
Cstdc1Cystatin-14; May play a specialized role in spermatogenesis. (130 aa)
Spp2Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover. (203 aa)
Cst6Cystatin E/M. (149 aa)
HrgHistidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell [...] (536 aa)
Kng1Kininogen-1 heavy chain; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of [...] (661 aa)
AhsgAlpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. (345 aa)
Rarres2Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...] (163 aa)
CstbCystatin-B; This is an intracellular thiol proteinase inhibitor. (98 aa)
Csta2Cystatin A family member 2; Belongs to the cystatin family. (97 aa)
Cst12Cystatin-12; May play a specialized role in spermatogenesis. (141 aa)
Cstdc4Cystatin domain-containing 4; Belongs to the cystatin family. (97 aa)
Cstdc6Cystatin domain-containing 6. (96 aa)
CampCathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. (172 aa)
Cstl1Cystatin-like 1; Belongs to the cystatin family. (140 aa)
Kng2HMW kininogen-II. (644 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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