(6 nodes) RNA exonuclease REXO1/REXO3/REXO4-like network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Isg20	Interferon-stimulated gene 20 kDa protein; Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses in an exonuclease- dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity). (300 aa)
	Rexo5	RNA exonuclease 5. (479 aa)
	Rexo1	RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro. (1213 aa)
	Isg20l2	Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. (368 aa)
	Aen	Apoptosis-enhancing nuclease; Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single- stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). (336 aa)
	Rexo4	RNA exonuclease 4; May function as an exonuclease. (432 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Isg20l2	Rexo5	ENSMUSP00000059783	ENSMUSP00000033218	Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.	RNA exonuclease 5.	0.448
Rexo1	Rexo5	ENSMUSP00000049705	ENSMUSP00000033218	RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro.	RNA exonuclease 5.	0.905
Rexo5	Isg20l2	ENSMUSP00000033218	ENSMUSP00000059783	RNA exonuclease 5.	Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.	0.448
Rexo5	Rexo1	ENSMUSP00000033218	ENSMUSP00000049705	RNA exonuclease 5.	RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro.	0.905