(13 nodes) Keratan sulfate degradation network (Mus musculus)

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	Galns	N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family. (520 aa)
	Ogn	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (298 aa)
	Hexb	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (536 aa)
	Hexa	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (528 aa)
	Acan	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2132 aa)
	Fmod	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. (376 aa)
	Lum	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (338 aa)
	Gns	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (544 aa)
	Prelp	Prolargin; May anchor basement membranes to the underlying connective tissue. (378 aa)
	Glb1	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (647 aa)
	Kera	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (351 aa)
	Glb1l	Beta-galactosidase-1-like protein; Probable glycosyl hydrolase. (646 aa)
	Omd	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity). (423 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acan	Fmod	ENSMUSP00000032835	ENSMUSP00000035489	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	0.929
Acan	Kera	ENSMUSP00000032835	ENSMUSP00000100923	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.791
Acan	Lum	ENSMUSP00000032835	ENSMUSP00000040877	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.869
Acan	Ogn	ENSMUSP00000032835	ENSMUSP00000021822	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.	0.721
Acan	Omd	ENSMUSP00000032835	ENSMUSP00000152066	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.711
Acan	Prelp	ENSMUSP00000032835	ENSMUSP00000048803	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.751
Fmod	Acan	ENSMUSP00000035489	ENSMUSP00000032835	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.929
Fmod	Kera	ENSMUSP00000035489	ENSMUSP00000100923	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.593
Fmod	Lum	ENSMUSP00000035489	ENSMUSP00000040877	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.842
Fmod	Ogn	ENSMUSP00000035489	ENSMUSP00000021822	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.	0.852
Fmod	Omd	ENSMUSP00000035489	ENSMUSP00000152066	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.818
Fmod	Prelp	ENSMUSP00000035489	ENSMUSP00000048803	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.792
Galns	Glb1	ENSMUSP00000015171	ENSMUSP00000055803	N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family.	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	0.971
Galns	Gns	ENSMUSP00000015171	ENSMUSP00000043167	N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.517
Glb1	Galns	ENSMUSP00000055803	ENSMUSP00000015171	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family.	0.971
Glb1	Gns	ENSMUSP00000055803	ENSMUSP00000043167	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.929
Glb1	Hexa	ENSMUSP00000055803	ENSMUSP00000026262	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.	0.946
Glb1	Hexb	ENSMUSP00000055803	ENSMUSP00000022169	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.	0.958
Gns	Galns	ENSMUSP00000043167	ENSMUSP00000015171	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family.	0.517
Gns	Glb1	ENSMUSP00000043167	ENSMUSP00000055803	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	0.929