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Hsd11b1 Hsd11b1 Akr1c6 Akr1c6 Akr1c18 Akr1c18 Ugt2b34 Ugt2b34 Ugt2b1 Ugt2b1 Ugt2b35 Ugt2b35 Alb Alb Hsd11b2 Hsd11b2 Ugt1a2 Ugt1a2 Cyp3a11 Cyp3a11 Abcb1a Abcb1a Serpina6 Serpina6 Akr1cl Akr1cl Ugt2b5 Ugt2b5 Ugt2b38 Ugt2b38 Ugt2b37 Ugt2b37 Akr1c20 Akr1c20 Ugt2b36 Ugt2b36 Ugt1a5 Ugt1a5 Akr1c14 Akr1c14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Hsd11b1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. (292 aa)
Akr1c6Estradiol 17 beta-dehydrogenase 5; Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4- androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha- androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively; Belongs to the aldo/keto reductase family. (323 aa)
Akr1c18Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP); Belongs to the aldo/keto reductase family. (323 aa)
Ugt2b34UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
Ugt2b1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Ugt2b35UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
AlbSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (386 aa)
Ugt1a2UDP-glucuronosyltransferase 1-2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (533 aa)
Cyp3a11Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family. (504 aa)
Abcb1aATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug- resistant cells (By similarity). (1276 aa)
Serpina6Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species; Belongs to the serpin family. (397 aa)
Akr1clAldo-keto reductase family 1, member C-like. (322 aa)
Ugt2b5UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (530 aa)
Ugt2b38UDP glucuronosyltransferase 2 family, polypeptide B38. (530 aa)
Ugt2b37UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Akr1c20Aldo-keto reductase family 1, member C20. (323 aa)
Ugt2b36UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Ugt1a5UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Akr1c143-alpha-hydroxysteroid dehydrogenase type 1. (323 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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