STRINGSTRING
Sec24b Sec24b Bcap31 Bcap31 Calr Calr Sar1b Sar1b Sec23a Sec23a H2-M10.2 H2-M10.2 Tapbp Tapbp H2-K1 H2-K1 Tap2 Tap2 H2-M10.1 H2-M10.1 Hspa5 Hspa5 Pdia3 Pdia3 Sec13 Sec13 H2-M3 H2-M3 Sec24d Sec24d H2-M10.6 H2-M10.6 H2-M1 H2-M1 Gm7030 Gm7030 H2-M11 H2-M11 Sec24c Sec24c H2-M10.5 H2-M10.5 H2-M10.4 H2-M10.4 H2-Q7 H2-Q7 H2-Q1 H2-Q1 H2-M10.3 H2-M10.3 H2-Q2 H2-Q2 H2-T22 H2-T22 H2-Q4 H2-Q4 H2-M9 H2-M9 Sec31a Sec31a B2m B2m H2-T3 H2-T3 H2-T23 H2-T23 Sec24a Sec24a Gm11127 Gm11127 Tap1 Tap1 H2-M2 H2-M2 H2-M5 H2-M5 Erap1 Erap1 H2-Q10 H2-Q10 Canx Canx
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Sec24bSec24-related gene family, member B (S. cerevisiae). (1251 aa)
Bcap31B-cell receptor-associated protein 31; Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. (245 aa)
CalrCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. (416 aa)
Sar1bGTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. (198 aa)
Sec23aProtein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (By similarity). Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane ; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
H2-M10.2Histocompatibility 2, M region locus 10.2; Belongs to the MHC class I family. (329 aa)
TapbpTapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (466 aa)
H2-K1H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (369 aa)
Tap2Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (702 aa)
H2-M10.1Histocompatibility 2, M region locus 10.1; Belongs to the MHC class I family. (331 aa)
Hspa5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimeriz [...] (655 aa)
Pdia3Protein disulfide-isomerase A3. (505 aa)
Sec13Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum ; Belongs to the WD repeat SEC13 family. (322 aa)
H2-M3Histocompatibility 2, M region locus 3; Belongs to the MHC class I family. (336 aa)
Sec24dSec24-related gene family, member D (S. cerevisiae). (1032 aa)
H2-M10.6Major histocompatibility complex class Ib M10.8; Belongs to the MHC class I family. (330 aa)
H2-M1Histocompatibility 2, M region locus 1; Belongs to the MHC class I family. (344 aa)
Gm7030Predicted gene 7030; Belongs to the MHC class I family. (285 aa)
H2-M11Histocompatibility 2, M region locus 11; Belongs to the MHC class I family. (335 aa)
Sec24cSec24-related gene family, member C (S. cerevisiae). (1096 aa)
H2-M10.5Histocompatibility 2, M region locus 10.5; Belongs to the MHC class I family. (330 aa)
H2-M10.4Histocompatibility 2, M region locus 10.4; Belongs to the MHC class I family. (331 aa)
H2-Q7H-2 class I histocompatibility antigen, Q7 alpha chain; Involved in the presentation of foreign antigens to the immune system. (334 aa)
H2-Q1Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family. (368 aa)
H2-M10.3Major histocompatibility complex class Ib M10.3; Belongs to the MHC class I family. (330 aa)
H2-Q2Histocompatibility 2, Q region locus 2; Belongs to the MHC class I family. (360 aa)
H2-T22Histocompatibility 2, T region locus 22; Belongs to the MHC class I family. (379 aa)
H2-Q4Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family. (354 aa)
H2-M9Histocompatibility 2, M region locus 9; Belongs to the MHC class I family. (342 aa)
Sec31aProtein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). Belongs to the WD repeat SEC31 family. (1230 aa)
B2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family. (119 aa)
H2-T3H-2 class I histocompatibility antigen, TLA(B) alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (384 aa)
H2-T23H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system. (357 aa)
Sec24aProtein transport protein Sec24A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may [...] (1090 aa)
Gm11127Predicted gene 11127; Belongs to the MHC class I family. (374 aa)
Tap1Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (724 aa)
H2-M2Histocompatibility 2, M region locus 2; Belongs to the MHC class I family. (343 aa)
H2-M5Histocompatibility 2, M region locus 5; Belongs to the MHC class I family. (348 aa)
Erap1Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play [...] (930 aa)
H2-Q10H-2 class I histocompatibility antigen, Q10 alpha chain; Involved in the presentation of foreign antigens to the immune system. (325 aa)
CanxCalnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] (591 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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