STRINGSTRING
Lztr1 Lztr1 Fbxo42 Fbxo42 Klhdc2 Klhdc2 Kbtbd7 Kbtbd7 Mkln1 Mkln1 Rabepk Rabepk Atrnl1 Atrnl1 Klhdc3 Klhdc3 Hcfc2 Hcfc2 Atrn Atrn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Lztr1Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. (837 aa)
Fbxo42F-box only protein 42; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity). (717 aa)
Klhdc2Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. (406 aa)
Kbtbd7Kelch repeat and BTB (POZ) domain-containing 7. (690 aa)
Mkln1Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. (735 aa)
RabepkRab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. (380 aa)
Atrnl1Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis. (1378 aa)
Klhdc3Kelch domain-containing protein 3; May be involved in meiotic recombination process. (382 aa)
Hcfc2Host cell factor 2. (722 aa)
AtrnAttractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity). (1428 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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