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Rpl6 Rpl6 Rplp1 Rplp1 Rps18 Rps18 Rpl19 Rpl19 Fos Fos Yy1 Yy1 Eif3e Eif3e Rps26 Rps26 Serp1 Serp1 Rps3a1 Rps3a1 Rps3 Rps3 Eif3f Eif3f Rps4x Rps4x Rpsa Rpsa Rps29 Rps29 Eif1 Eif1 Rpl21 Rpl21 Rpl37 Rpl37 Rps23 Rps23 Rpl37a Rpl37a Rps27rt Rps27rt Nkrf Nkrf Rps15 Rps15 Rpl7 Rpl7 Rpl15 Rpl15 Rps25 Rps25 Rpl3 Rpl3 Rpl5 Rpl5 Rplp2 Rplp2 Rplp0 Rplp0 Rpl31 Rpl31 Rps2 Rps2 Eef1g Eef1g Eif3d Eif3d Rpl23a Rpl23a Rps8 Rps8 Rps6 Rps6 Jun Jun Rps19 Rps19 Rps9 Rps9 Ankrd36 Ankrd36 Rpl36al Rpl36al Rpl36a Rpl36a Rpl9 Rpl9 Rps10 Rps10 Rpl35a Rpl35a Rpl39 Rpl39 Rpl13a Rpl13a Rpl29 Rpl29 Rpl22 Rpl22 Rps15a Rps15a Rps13 Rps13 Rpl26 Rpl26 Rpl14 Rpl14 Rps27 Rps27 Rps28 Rps28 Rpl32 Rpl32 Rpl18 Rpl18 Rps24 Rps24 Rps14 Rps14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rpl660S ribosomal protein L6; Component of the large ribosomal subunit. (296 aa)
Rplp160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
Rps1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
Rpl1960S ribosomal protein L19. (196 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (380 aa)
Yy1Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activa [...] (414 aa)
Eif3eEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
Rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
Serp1Stress-associated endoplasmic reticulum protein 1; Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). (66 aa)
Rps3a140S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
Rps340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa)
Eif3fEukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (361 aa)
Rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
Rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
Rps2940S ribosomal protein S29. (56 aa)
Eif1Eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity); Belongs to the SUI1 family. (113 aa)
Rpl2160S ribosomal protein L21; Component of the large ribosomal subunit. (160 aa)
Rpl3760S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Rpl37a60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family. (92 aa)
Rps27rt40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
NkrfNF-kappa-B-repressing factor; Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK- kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (By similarity). (690 aa)
Rps1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
Rpl760S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (270 aa)
Rpl1560S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
Rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
Rpl360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
Rpl560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
Rplp260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa)
Rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
Rpl3160S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (125 aa)
Rps240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (293 aa)
Eef1gElongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (437 aa)
Eif3dEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (548 aa)
Rpl23a60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. (156 aa)
Rps840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
Rps640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
JunTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity). (334 aa)
Rps1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
Rps940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
Ankrd36Ankyrin repeat domain 36. (1415 aa)
Rpl36al60S ribosomal protein L36a. (106 aa)
Rpl36aRibosomal protein L36A. (106 aa)
Rpl960S ribosomal protein L9; Belongs to the universal ribosomal protein uL6 family. (192 aa)
Rps1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
Rpl35a60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
Rpl3960S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
Rpl13a60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as cerupla [...] (203 aa)
Rpl2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (160 aa)
Rpl2260S ribosomal protein L22. (128 aa)
Rps15a40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
Rps1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Rpl2660S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
Rpl1460S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family. (217 aa)
Rps27Ribosomal protein S27. (84 aa)
Rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
Rpl3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
Rpl1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
Rps2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. (133 aa)
Rps1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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