(5 nodes) (2007) Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. network (Mus musculus)

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Your Input:
	Klrc1	Killer cell lectin-like receptor subfamily C, member 1. (244 aa)
	Cd4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (457 aa)
	H2-Q1	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family. (368 aa)
	H2-T23	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system. (357 aa)
	Klrd1	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	H2-Q1	ENSMUSP00000024044	ENSMUSP00000072942	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	0.692
Cd4	H2-T23	ENSMUSP00000024044	ENSMUSP00000099739	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.524
Cd4	Klrc1	ENSMUSP00000024044	ENSMUSP00000032270	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Killer cell lectin-like receptor subfamily C, member 1.	0.851
Cd4	Klrd1	ENSMUSP00000024044	ENSMUSP00000107694	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.787
H2-Q1	Cd4	ENSMUSP00000072942	ENSMUSP00000024044	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.692
H2-Q1	H2-T23	ENSMUSP00000072942	ENSMUSP00000099739	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.734
H2-Q1	Klrc1	ENSMUSP00000072942	ENSMUSP00000032270	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	Killer cell lectin-like receptor subfamily C, member 1.	0.985
H2-Q1	Klrd1	ENSMUSP00000072942	ENSMUSP00000107694	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.939
H2-T23	Cd4	ENSMUSP00000099739	ENSMUSP00000024044	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.524
H2-T23	H2-Q1	ENSMUSP00000099739	ENSMUSP00000072942	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	0.734
H2-T23	Klrc1	ENSMUSP00000099739	ENSMUSP00000032270	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	Killer cell lectin-like receptor subfamily C, member 1.	0.997
H2-T23	Klrd1	ENSMUSP00000099739	ENSMUSP00000107694	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.998
Klrc1	Cd4	ENSMUSP00000032270	ENSMUSP00000024044	Killer cell lectin-like receptor subfamily C, member 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.851
Klrc1	H2-Q1	ENSMUSP00000032270	ENSMUSP00000072942	Killer cell lectin-like receptor subfamily C, member 1.	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	0.985
Klrc1	H2-T23	ENSMUSP00000032270	ENSMUSP00000099739	Killer cell lectin-like receptor subfamily C, member 1.	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.997
Klrc1	Klrd1	ENSMUSP00000032270	ENSMUSP00000107694	Killer cell lectin-like receptor subfamily C, member 1.	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.999
Klrd1	Cd4	ENSMUSP00000107694	ENSMUSP00000024044	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.787
Klrd1	H2-Q1	ENSMUSP00000107694	ENSMUSP00000072942	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family.	0.939
Klrd1	H2-T23	ENSMUSP00000107694	ENSMUSP00000099739	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.998
Klrd1	Klrc1	ENSMUSP00000107694	ENSMUSP00000032270	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	Killer cell lectin-like receptor subfamily C, member 1.	0.999