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Ugt1a10 Ugt1a10 Vezf1 Vezf1 Arc Arc Ugt2b34 Ugt2b34 Ugt2b1 Ugt2b1 Ugt2b35 Ugt2b35 Ugt2a3 Ugt2a3 Alb Alb Cyb5b Cyb5b Ugt1a2 Ugt1a2 Ppp1r9b Ppp1r9b Mbp Mbp Ugt2b5 Ugt2b5 Nrgn Nrgn Cyp2b10 Cyp2b10 Ugt2b38 Ugt2b38 Ugt1a1 Ugt1a1 Ugt1a9 Ugt1a9 Ugt2b37 Ugt2b37 Ugt2a2 Ugt2a2 Cyp2b9 Cyp2b9 Ugt2b36 Ugt2b36 Ugt1a5 Ugt1a5 Ugt1a6a Ugt1a6a Ugt1a6b Ugt1a6b Ugt1a8 Ugt1a8 Slc35a2 Slc35a2 Ugt2a1 Ugt2a1 Cyb5a Cyb5a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ugt1a10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Vezf1Vascular endothelial zinc finger 1. (518 aa)
ArcActivity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (By similarity). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: [...] (396 aa)
Ugt2b34UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
Ugt2b1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Ugt2b35UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Ugt2a3UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family. (534 aa)
AlbSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
Cyb5bCytochrome b5 type B; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. (146 aa)
Ugt1a2UDP-glucuronosyltransferase 1-2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (533 aa)
Ppp1r9bNeurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pl [...] (817 aa)
MbpMyelin basic protein; The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give [...] (250 aa)
Ugt2b5UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (530 aa)
NrgnNEUG(55-78); Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning. Belongs to the neurogranin family. (78 aa)
Cyp2b10Cytochrome P450 2B10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Ugt2b38UDP glucuronosyltransferase 2 family, polypeptide B38. (530 aa)
Ugt1a1UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (535 aa)
Ugt1a9UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (528 aa)
Ugt2b37UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Ugt2a2UDP-glucuronosyltransferase 2A2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (528 aa)
Cyp2b9Cytochrome P450 2B9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Ugt2b36UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Ugt1a5UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Ugt1a6aUDP-glucuronosyltransferase 1-6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4- nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4- hydroxybiphenyl, androgens and estrogens are not substrates. 2- hydroxybiphenyl is an excellent substrate; Belongs to the UDP-glycosyltransferase family. (531 aa)
Ugt1a6bUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
Ugt1a8UDP-glucuronosyltransferase 1-7C; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. (530 aa)
Slc35a2UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (393 aa)
Ugt2a1UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. (528 aa)
Cyb5aCytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation. (134 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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