(9 nodes) (2018) Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Mus musculus). network (Mus musculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	H2-Aa	H-2 class II histocompatibility antigen, A-B alpha chain. (256 aa)
	H2-Ob	Histocompatibility 2, O region beta locus. (271 aa)
	Rabep2	Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Belongs to the rabaptin family. (554 aa)
	H2-D1	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (362 aa)
	Mapre2	Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). (326 aa)
	H2-Eb1	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family. (264 aa)
	H2-K1	H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (369 aa)
	Mapre3	Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] (281 aa)
	H2-Ab1	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family. (265 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2-Aa	H2-Ab1	ENSMUSP00000046105	ENSMUSP00000041008	H-2 class II histocompatibility antigen, A-B alpha chain.	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	0.999
H2-Aa	H2-D1	ENSMUSP00000046105	ENSMUSP00000134570	H-2 class II histocompatibility antigen, A-B alpha chain.	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.801
H2-Aa	H2-Eb1	ENSMUSP00000046105	ENSMUSP00000158533	H-2 class II histocompatibility antigen, A-B alpha chain.	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	0.995
H2-Aa	H2-K1	ENSMUSP00000046105	ENSMUSP00000025181	H-2 class II histocompatibility antigen, A-B alpha chain.	H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.842
H2-Aa	H2-Ob	ENSMUSP00000046105	ENSMUSP00000092985	H-2 class II histocompatibility antigen, A-B alpha chain.	Histocompatibility 2, O region beta locus.	0.896
H2-Ab1	H2-Aa	ENSMUSP00000041008	ENSMUSP00000046105	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	H-2 class II histocompatibility antigen, A-B alpha chain.	0.999
H2-Ab1	H2-D1	ENSMUSP00000041008	ENSMUSP00000134570	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.820
H2-Ab1	H2-Eb1	ENSMUSP00000041008	ENSMUSP00000158533	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	0.999
H2-Ab1	H2-K1	ENSMUSP00000041008	ENSMUSP00000025181	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.857
H2-Ab1	H2-Ob	ENSMUSP00000041008	ENSMUSP00000092985	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	Histocompatibility 2, O region beta locus.	0.814
H2-D1	H2-Aa	ENSMUSP00000134570	ENSMUSP00000046105	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	H-2 class II histocompatibility antigen, A-B alpha chain.	0.801
H2-D1	H2-Ab1	ENSMUSP00000134570	ENSMUSP00000041008	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	0.820
H2-D1	H2-Eb1	ENSMUSP00000134570	ENSMUSP00000158533	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	0.863
H2-D1	H2-K1	ENSMUSP00000134570	ENSMUSP00000025181	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.954
H2-D1	H2-Ob	ENSMUSP00000134570	ENSMUSP00000092985	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	Histocompatibility 2, O region beta locus.	0.802
H2-Eb1	H2-Aa	ENSMUSP00000158533	ENSMUSP00000046105	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	H-2 class II histocompatibility antigen, A-B alpha chain.	0.995
H2-Eb1	H2-Ab1	ENSMUSP00000158533	ENSMUSP00000041008	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family.	0.999
H2-Eb1	H2-D1	ENSMUSP00000158533	ENSMUSP00000134570	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.863
H2-Eb1	H2-K1	ENSMUSP00000158533	ENSMUSP00000025181	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family.	0.828
H2-Eb1	H2-Ob	ENSMUSP00000158533	ENSMUSP00000092985	H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.	Histocompatibility 2, O region beta locus.	0.812