11 items (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Stfa1	Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (97 aa)
	Emd	Emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C (By similarity). (259 aa)
	Dnmt1	DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] (1620 aa)
	Cstb	Cystatin-B; This is an intracellular thiol proteinase inhibitor. (98 aa)
	Ctss	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. (341 aa)
	Cst3	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. (140 aa)
	Stfa3	Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (103 aa)
	Stfa2l1	Stefin-2; This is an intracellular thiol proteinase inhibitor. (103 aa)
	Csta1	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. (97 aa)
	B2m	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family. (119 aa)
	Cth	Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] (398 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2m	Cst3	ENSMUSP00000099534	ENSMUSP00000028938	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	0.800
B2m	Cstb	ENSMUSP00000099534	ENSMUSP00000005185	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	0.486
B2m	Ctss	ENSMUSP00000099534	ENSMUSP00000015667	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.556
Cst3	B2m	ENSMUSP00000028938	ENSMUSP00000099534	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	0.800
Cst3	Csta1	ENSMUSP00000028938	ENSMUSP00000093795	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	0.651
Cst3	Cstb	ENSMUSP00000028938	ENSMUSP00000005185	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	0.682
Cst3	Ctss	ENSMUSP00000028938	ENSMUSP00000015667	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.893
Csta1	Cst3	ENSMUSP00000093795	ENSMUSP00000028938	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	0.651
Csta1	Ctss	ENSMUSP00000093795	ENSMUSP00000015667	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.779
Csta1	Stfa1	ENSMUSP00000093795	ENSMUSP00000156337	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.741
Csta1	Stfa2l1	ENSMUSP00000093795	ENSMUSP00000078181	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-2; This is an intracellular thiol proteinase inhibitor.	0.763
Csta1	Stfa3	ENSMUSP00000093795	ENSMUSP00000067445	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.804
Cstb	B2m	ENSMUSP00000005185	ENSMUSP00000099534	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	0.486
Cstb	Cst3	ENSMUSP00000005185	ENSMUSP00000028938	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	0.682
Cstb	Ctss	ENSMUSP00000005185	ENSMUSP00000015667	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	0.616
Ctss	B2m	ENSMUSP00000015667	ENSMUSP00000099534	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.	0.556
Ctss	Cst3	ENSMUSP00000015667	ENSMUSP00000028938	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.	0.893
Ctss	Csta1	ENSMUSP00000015667	ENSMUSP00000093795	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	0.779
Ctss	Cstb	ENSMUSP00000015667	ENSMUSP00000005185	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	Cystatin-B; This is an intracellular thiol proteinase inhibitor.	0.616
Ctss	Stfa2l1	ENSMUSP00000015667	ENSMUSP00000078181	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family.	Stefin-2; This is an intracellular thiol proteinase inhibitor.	0.422