Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione peroxidase 2.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione peroxidase 6; Belongs to the glutathione peroxidase family.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity).

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutathione synthetase; Belongs to the eukaryotic GSH synthase family.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity).

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Transcription factor NF-E2 45 kDa subunit; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1- like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron; Belongs to t [...]

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]

Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.

Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain.

Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family.