STRINGSTRING
Spag8 Spag8 Tekt1 Tekt1 Cfap52 Cfap52 Tubal3 Tubal3 Ribc2 Ribc2 Tekt4 Tekt4 Efhc2 Efhc2 Dusp21 Dusp21 Ribc1 Ribc1 Serpine2 Serpine2 Cfap126 Cfap126 Enkur Enkur Fam166a Fam166a 1110017D15Rik 1110017D15Rik Saxo1 Saxo1 1700001C02Rik 1700001C02Rik Tuba8 Tuba8 Gp2 Gp2 Cfap20 Cfap20 Tex43 Tex43 Tekt3 Tekt3 Efhc1 Efhc1 Pacrg Pacrg Tekt5 Tekt5 Tuba1c Tuba1c Tex37 Tex37 Tuba1b Tuba1b Cfap161 Cfap161 Cfap45 Cfap45 1700007K13Rik 1700007K13Rik Tuba3b Tuba3b Tuba1a Tuba1a Tekt2 Tekt2 Ccdc105 Ccdc105 Cfap53 Cfap53 Efcab6 Efcab6 Spaca9 Spaca9 Cfap77 Cfap77 Tuba4a Tuba4a Nme7 Nme7 Ppp1r32 Ppp1r32 Fam183b Fam183b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Spag8Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). (470 aa)
Tekt1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). (418 aa)
Cfap52Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
Tubal3Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (446 aa)
Ribc2RIB43A-like with coiled-coils protein 2; Belongs to the RIB43A family. (377 aa)
Tekt4Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility. (447 aa)
Efhc2EF-hand domain-containing family member C2. (750 aa)
Dusp21Dual specificity phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (189 aa)
Ribc1RIB43A-like with coiled-coils protein 1; Belongs to the RIB43A family. (379 aa)
Serpine2Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. (397 aa)
Cfap126Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear; Belongs to the Flattop family. (189 aa)
EnkurEnkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (255 aa)
Fam166aProtein FAM166A; Belongs to the UPF0605 family. (319 aa)
1110017D15RikSpermatid-specific manchette-related protein 1; May be involved in differentiation or function of ciliated cells (By similarity). May play a role in spermatogenesis. Belongs to the SMRP1 family. (260 aa)
Saxo1Stabilizer of axonemal microtubules 1. (476 aa)
1700001C02RikProtein FAM166C. (200 aa)
Tuba8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (449 aa)
Gp2Pancreatic secretory granule membrane major glycoprotein GP2. (534 aa)
Cfap20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). (193 aa)
Tex43Testis-expressed protein 43. (141 aa)
Tekt3Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility; Belongs to the tektin family. (490 aa)
Efhc1EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis. (648 aa)
PacrgParkin coregulated gene protein homolog; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). (241 aa)
Tekt5Tektin-5; May be a structural component of the sperm flagellum. (557 aa)
Tuba1cDetyrosinated tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (449 aa)
Tex37Testis-expressed sequence 37 protein. (180 aa)
Tuba1bDetyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (451 aa)
Cfap161Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (303 aa)
Cfap45Cilia and flagella-associated protein 45. (551 aa)
1700007K13RikUPF0691 protein C9orf116 homolog. (167 aa)
Tuba3bDetyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (450 aa)
Tuba1aDetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
Tekt2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Belongs to the tektin family. (430 aa)
Ccdc105Coiled-coil domain-containing protein 105. (499 aa)
Cfap53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
Efcab6EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. (1516 aa)
Spaca9Sperm acrosome-associated protein 9. (168 aa)
Cfap77Cilia and flagella-associated protein 77. (271 aa)
Tuba4aTubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
Nme7Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (395 aa)
Ppp1r32Protein phosphatase 1 regulatory subunit 32. (427 aa)
Fam183bProtein FAM183B. (137 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.