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Clec2f Clec2f Clec2g Clec2g Clec10a Clec10a Ncan Ncan Clec11a Clec11a Fcer2a Fcer2a Clec3a Clec3a Cd209d Cd209d Dgcr2 Dgcr2 Cd209a Cd209a Klra8 Klra8 Clec4f Clec4f Klra17 Klra17 Chodl Chodl Reg2 Reg2 Clec4n Clec4n Mbl2 Mbl2 Clec3b Clec3b Sell Sell Sele Sele Mrc1 Mrc1 Ly75 Ly75 Prg3 Prg3 Prg2 Prg2 Atrn Atrn Reg4 Reg4 Cd72 Cd72 Reg3g Reg3g Klrg1 Klrg1 Clec4e Clec4e Clec4d Clec4d Clec4a2 Clec4a2 Klrk1 Klrk1 Klrb1f Klrb1f Clec2e Clec2e Cd69 Cd69 Clec2d Clec2d Clec12b Clec12b Clec1b Clec1b Olr1 Olr1 Klrc1 Klrc1 Klra1 Klra1 Klrb1b Klrb1b Klrb1a Klrb1a Clec2h Clec2h Acan Acan Cd209e Cd209e Colec10 Colec10 Cd209c Cd209c Cd207 Cd207 Clec18a Clec18a Clec1a Clec1a Mgl2 Mgl2 Colec11 Colec11 Pkd1 Pkd1 Klri2 Klri2 Clec14a Clec14a Klre1 Klre1 Clec9a Clec9a Clec4g Clec4g Clec2m Clec2m Clec4a1 Clec4a1 Clec12a Clec12a Cd248 Cd248 Klrc3 Klrc3 Frem1 Frem1 Klra6 Klra6 Cd302 Cd302 Sftpd Sftpd Atrnl1 Atrnl1 Clec4b1 Clec4b1 Clec4a4 Clec4a4 Cd209b Cd209b Klri1 Klri1 Clec4b2 Clec4b2 Clec4a3 Clec4a3 Klra2 Klra2 Reg3d Reg3d Bcan Bcan Asgr1 Asgr1 Klrh1 Klrh1 Klrg2 Klrg2 Reg3b Reg3b Pkd1l2 Pkd1l2 Layn Layn Cd93 Cd93 Thbd Thbd Mrc2 Mrc2 Reg3a Reg3a Asgr2 Asgr2 Pkd1l3 Pkd1l3 Vcan Vcan Klra3 Klra3 Klra7 Klra7 Klra10 Klra10 Klra9 Klra9 Klrc2 Klrc2 Klrd1 Klrd1 Klrb1 Klrb1 Pla2r1 Pla2r1 Clec2l Clec2l Klra5 Klra5 Klra4 Klra4 Cd209f Cd209f Cd209g Cd209g Clec5a Clec5a Selp Selp Clec2i Clec2i Sftpa1 Sftpa1 Klrb1c Klrb1c Reg1 Reg1 Gm44511 Gm44511 Mbl1 Mbl1 Colec12 Colec12
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Clec2fC-type lectin domain family 2 member F. (208 aa)
Clec2gC-type lectin domain family 2 member G; Inhibits osteoclast formation. (269 aa)
Clec10aC-type lectin domain family 10 member A; Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity. (305 aa)
NcanNeurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. (1268 aa)
Clec11aC-type lectin domain family 11 member A; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone. (328 aa)
Fcer2aLow affinity immunoglobulin epsilon Fc receptor; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). (331 aa)
Clec3aC-type lectin domain family 3 member A; Promotes cell adhesion to laminin and fibronectin. (196 aa)
Cd209dCD209 antigen-like protein D; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. (237 aa)
Dgcr2Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. (549 aa)
Cd209aCD209 antigen-like protein A; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. (238 aa)
Klra8Killer cell lectin-like receptor 8; Receptor on natural killer (NK) cells for class I MHC. (266 aa)
Clec4fC-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis. (548 aa)
Klra17Killer cell lectin-like receptor, subfamily A, member 17. (273 aa)
ChodlChondrolectin; May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance (By similarity). (273 aa)
Reg2Lithostathine-2; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (173 aa)
Clec4nC-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk- CARD9-NF [...] (209 aa)
Mbl2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (244 aa)
Clec3bTetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). (202 aa)
SellL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity). (372 aa)
SeleE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. (619 aa)
Mrc1Macrophage mannose receptor 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. (1456 aa)
Ly75Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). (1723 aa)
Prg3Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. (222 aa)
Prg2Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity). (223 aa)
AtrnAttractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity). (1428 aa)
Reg4Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity). (157 aa)
Cd72B-cell differentiation antigen CD72; Plays a role in B-cell proliferation and differentiation. (361 aa)
Reg3gRegenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] (174 aa)
Klrg1Killer cell lectin-like receptor subfamily G member 1; Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E- cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. (188 aa)
Clec4eC-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] (214 aa)
Clec4dC-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] (219 aa)
Clec4a2C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. (262 aa)
Klrk1NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (232 aa)
Klrb1fKiller cell lectin-like receptor subfamily B member 1F; Binds CLEC2I/Clr-g leading to activation of natural killer cells or costimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells. (217 aa)
Clec2eC-type lectin domain family 2 member E; Lectin-type cell surface receptor. (216 aa)
Cd69Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. (199 aa)
Clec2dC-type lectin domain family 2 member D; Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans. (207 aa)
Clec12bC-type lectin domain family 12 member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity). (275 aa)
Clec1bC-type lectin domain family 1 member B; C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (229 aa)
Olr1Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (363 aa)
Klrc1Killer cell lectin-like receptor subfamily C, member 1. (244 aa)
Klra1T-cell surface glycoprotein YE1/48; Receptor on natural killer (NK) cells for H-2d alleles. Inhibits the activity of NK cells thus preventing cell lysis. (262 aa)
Klrb1bKiller cell lectin-like receptor subfamily B member 1B allele B; Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells. (223 aa)
Klrb1aKiller cell lectin-like receptor subfamily B member 1A; Plays a stimulatory role on natural killer (NK) cell cytotoxicity. (233 aa)
Clec2hC-type lectin domain family 2 member H; Lectin-type cell surface receptor. (218 aa)
AcanAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2132 aa)
Cd209eCD209 antigen-like protein E; Putative pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. (208 aa)
Colec10Collectin-10; Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration. Belongs to the COLEC10/COLEC11 family. (277 aa)
Cd209cCD209 antigen-like protein C; Probable pathogen-recognition receptor. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. (178 aa)
Cd207C-type lectin domain family 4 member K; Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. (331 aa)
Clec18aC-type lectin domain family 18 member A. (534 aa)
Clec1aC-type lectin domain family 1 member A. (269 aa)
Mgl2Macrophage galactose N-acetyl-galactosamine-specific lectin 2. (332 aa)
Colec11Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (272 aa)
Pkd1Polycystin-1; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback [...] (4293 aa)
Klri2Killer cell lectin-like receptor subfamily I member 2; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity. (248 aa)
Clec14aC-type lectin domain family 14 member A. (459 aa)
Klre1Killer cell lectin-like receptor subfamily E member 1; Lectin-like receptor for natural killer (NK) cells. Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner. Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation. Plays a role in allogeneic recognition by the immune system. (226 aa)
Clec9aC-type lectin domain family 9 member A; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. (264 aa)
Clec4gC-type lectin domain family 4 member G; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner. (294 aa)
Clec2mC-type lectin domain family 2, member m. (189 aa)
Clec4a1C-type lectin domain family 4, member a1. (245 aa)
Clec12aC-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. (267 aa)
Cd248Endosialin; May play a role in angiogenesis or vascular function. (765 aa)
Klrc3Killer cell lectin-like receptor subfamily C, member 3. (221 aa)
Frem1FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. (2191 aa)
Klra6Killer cell lectin-like receptor 6; Receptor on natural killer (NK) cells for class I MHC. (266 aa)
Cd302CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. (228 aa)
SftpdPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family. (374 aa)
Atrnl1Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis. (1378 aa)
Clec4b1Dendritic cell immuno-activating receptor alpha isoform. (209 aa)
Clec4a4C-type lectin domain family 4, member a4. (236 aa)
Cd209bCD209 antigen-like protein B; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (325 aa)
Klri1Killer cell lectin-like receptor subfamily I member 1; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity. (248 aa)
Clec4b2Antigen presenting cell lectin-like receptor A1. (208 aa)
Clec4a3C-type lectin domain family 4, member a3. (237 aa)
Klra2Killer cell lectin-like receptor 2; Receptor on natural killer (NK) cells for class I MHC. (321 aa)
Reg3dRegenerating islet-derived 3 delta. (175 aa)
BcanBrevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. (883 aa)
Asgr1Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. (284 aa)
Klrh1Killer cell lectin-like receptor subfamily H, member 1. (223 aa)
Klrg2Killer cell lectin-like receptor subfamily G member 2. (387 aa)
Reg3bRegenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. (175 aa)
Pkd1l2Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). (2461 aa)
LaynLayilin; Receptor for hyaluronate. (381 aa)
Cd93Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development. (644 aa)
ThbdThrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. (577 aa)
Mrc2C-type mannose receptor 2; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the [...] (1479 aa)
Reg3aRegenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. (175 aa)
Asgr2Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. (301 aa)
Pkd1l3Polycystic kidney disease protein 1-like 3; Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. Belongs to the polycystin family. (2201 aa)
VcanVersican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3354 aa)
Klra3Killer cell lectin-like receptor 3; Receptor on natural killer (NK) cells for class I MHC. (266 aa)
Klra7Killer cell lectin-like receptor 7; Receptor on natural killer (NK) cells for class I MHC. (280 aa)
Klra10Killer cell lectin-like receptor subfamily A, member 10. (266 aa)
Klra9Killer cell lectin-like receptor subfamily A, member 9. (266 aa)
Klrc2Killer cell lectin-like receptor subfamily C, member 2. (238 aa)
Klrd1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
Klrb1Killer cell lectin-like receptor subfamily B member 1. (214 aa)
Pla2r1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascad [...] (1487 aa)
Clec2lC-type lectin domain family 2 member L. (211 aa)
Klra5Killer cell lectin-like receptor 5; Receptor on natural killer (NK) cells for class I MHC. (266 aa)
Klra4Killer cell lectin-like receptor 4; Receptor on natural killer (NK) cells for class I MHC. (263 aa)
Cd209fCD209f antigen. (255 aa)
Cd209gCD209g antigen. (194 aa)
Clec5aC-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (190 aa)
SelpP-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. (768 aa)
Clec2iC-type lectin domain family 2 member I; Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production. (246 aa)
Sftpa1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages ; Belongs to the SFTPA family. (248 aa)
Klrb1cKiller cell lectin-like receptor subfamily B member 1C; Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production. (271 aa)
Reg1Lithostathine-1; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (165 aa)
Gm44511Killer cell lectin-like receptor subfamily B member 1B allele A; Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells. (223 aa)
Mbl1Mannose-binding protein A; Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (239 aa)
Colec12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells (By similarity). Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifica [...] (742 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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