STRINGSTRING
Vpreb3 Vpreb3 Vsig2 Vsig2 Hapln2 Hapln2 Btnl10 Btnl10 Hapln1 Hapln1 Robo1 Robo1 Cd4 Cd4 Btnl2 Btnl2 Acan Acan Mpzl2 Mpzl2 Btn1a1 Btn1a1 F11r F11r Gpa33 Gpa33 Mpz Mpz Cd8b1 Cd8b1 Vpreb1 Vpreb1 Vpreb2 Vpreb2 Nectin2 Nectin2 Gm1123 Gm1123 Btnl1 Btnl1 Cd86 Cd86 Bcan Bcan Mog Mog Ptgfrn Ptgfrn Igkv4-71 Igkv4-71 Mpzl1 Mpzl1 Thy1 Thy1 Skint6 Skint6 Ermap Ermap Skint1 Skint1 Cd200 Cd200 Skint5 Skint5 Igkv4-54 Igkv4-54 Ighv6-5 Ighv6-5 Ighv6-4 Ighv6-4 Igkv4-62 Igkv4-62 Skint2 Skint2 Hapln3 Hapln3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Vpreb3Pre-B lymphocyte gene 3. (123 aa)
Vsig2V-set and immunoglobulin domain-containing protein 2. (328 aa)
Hapln2Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid; Belongs to the HAPLN family. (341 aa)
Btnl10Butyrophilin-like protein 10; Belongs to the immunoglobulin superfamily. BTN/MOG family. (275 aa)
Hapln1Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. (356 aa)
Robo1Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its intera [...] (1612 aa)
Cd4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (457 aa)
Btnl2Butyrophilin-like protein 2; Negative regulator of T-cell proliferation. Belongs to the immunoglobulin superfamily. BTN/MOG family. (514 aa)
AcanAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2132 aa)
Mpzl2Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family. (215 aa)
Btn1a1Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. (524 aa)
F11rJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity); Belongs to the immunoglobulin superfamily. (300 aa)
Gpa33Cell surface A33 antigen; May play a role in cell-cell recognition and signaling. (319 aa)
MpzMyelin protein P0; Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Belongs to the myelin P0 protein family. (248 aa)
Cd8b1T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (213 aa)
Vpreb1Immunoglobulin iota chain; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B- cell differentiation; Belongs to the immunoglobulin superfamily. (142 aa)
Vpreb2Immunoglobulin omega chain; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B- cell differentiation; Belongs to the immunoglobulin superfamily. (142 aa)
Nectin2Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (530 aa)
Gm1123CAR-like soluble protein. (390 aa)
Btnl1Butyrophilin-like protein 1. (509 aa)
Cd86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (309 aa)
BcanBrevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. (883 aa)
MogMyelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. (247 aa)
PtgfrnProstaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration. (879 aa)
Igkv4-71Ig kappa chain V-VI region NQ2-17.4.1; Anti-2-phenyl oxazolone (PHOX) Antibody. (96 aa)
Mpzl1Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity); Belongs [...] (270 aa)
Thy1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (162 aa)
Skint6Selection and upkeep of intraepithelial T-cells protein 6; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. (1240 aa)
ErmapErythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family. (592 aa)
Skint1Selection and upkeep of intraepithelial T-cells protein 1; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells. (364 aa)
Cd200OX-2 membrane glycoprotein; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity). (278 aa)
Skint5Selection and upkeep of intraepithelial T-cells protein 5; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. (1475 aa)
Igkv4-54Immunoglobulin kappa chain variable 4-54. (96 aa)
Ighv6-5Ig heavy chain V-III region J606. (99 aa)
Ighv6-4Immunoglobulin heavy variable V6-4. (99 aa)
Igkv4-62Ig kappa chain V-VI region NQ2-6.1. (96 aa)
Skint2Selection and upkeep of intraepithelial T-cells protein 2; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus. (400 aa)
Hapln3Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. Belongs to the HAPLN family. (359 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (34%) [HD]