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| | Lgr5 | Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the [...] (907 aa) |
| | Gpr137b | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] (385 aa) |
| | Gpr180 | Integral membrane protein GPR180. (441 aa) |
| | Adgrg7 | Adhesion G-protein coupled receptor G7; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (785 aa) |
| | Adgrf4 | Adhesion G protein-coupled receptor F4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (698 aa) |
| | Gpr37l1 | G-protein coupled receptor 37-like 1; G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh path [...] (481 aa) |
| | Vmn2r1 | Vomeronasal type-2 receptor 1; Putative pheromone receptor; Belongs to the G-protein coupled receptor 3 family. (912 aa) |
| | Gpr89 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. (455 aa) |
| | Tas1r2 | Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. (843 aa) |
| | Tas1r1 | Taste receptor type 1 member 1; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. (842 aa) |
| | Tas1r3 | Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. (858 aa) |
| | Adgra3 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. (1310 aa) |
| | Tas2r116 | Taste receptor type 2 member 116; Putative taste receptor which may play a role in the perception of bitterness. (305 aa) |
| | Rho | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. (348 aa) |
| | Mrgprf | Mas-related G-protein coupled receptor member F; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (343 aa) |
| | Brs3 | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (399 aa) |
| | Gpr165 | G-protein coupled receptor 165; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | Opn1mw | Medium-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (359 aa) |
| | Adgra2 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2- tethering function does not re [...] (1336 aa) |
| | Gpr83 | Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor. (423 aa) |
| | Lgr6 | Leucine-rich repeat-containing G-protein coupled receptor 6; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity). (967 aa) |
| | Ptgdr2 | Prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)- protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). (382 aa) |
| | Cmklr1 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte meta [...] (371 aa) |
| | Taar3 | Trace amine-associated receptor 3; Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. (343 aa) |
| | Gpr176 | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. (515 aa) |
| | Gpr12 | G-protein coupled receptor 12; Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production (By similarity). Promotes neurite outgrowth and blocks myelin inhibition in neurons. (334 aa) |
| | Gpr63 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function. (425 aa) |
| | Gpr26 | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. (337 aa) |
| | Gpr34 | Probable G-protein coupled receptor 34; Orphan receptor. (375 aa) |
| | Adgrg6 | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein- signaling pathways. Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus- dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. ECO:0000250|UniProtKB:Q86SQ4. (1165 aa) |
| | Taar9 | Trace amine-associated receptor 9; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family. (348 aa) |
| | Lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (951 aa) |
| | Gpr19 | Probable G-protein coupled receptor 19; Orphan receptor. (415 aa) |
| | Gpr33 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor. (339 aa) |
| | Olfr6 | Olfactory receptor 6; Odorant receptor. (316 aa) |
| | Adgrf1 | Adhesion G-protein coupled receptor F1; Orphan receptor. (908 aa) |
| | Gpr150 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | Gpr158 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. (1200 aa) |
| | Adgrg3 | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells via the small GTPases RhoA and CDC42 (By similarity). Regulates B-cell development. Seems to signal through G-alpha(q)-proteins (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (542 aa) |
| | Gpr1 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. (353 aa) |
| | Olfr147 | Olfactory receptor 147; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (317 aa) |
| | Vmn1r45 | Vomeronasal type-1 receptor 45; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | Gpr37 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). (600 aa) |
| | Mrgprb8 | Mas-related G-protein coupled receptor member B8; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (330 aa) |
| | Gpr183 | G-protein coupled receptor 183; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Collaborates with CXCR5 to mediate B-cell migrat [...] (357 aa) |
| | Olfr1030 | Olfactory receptor 1030; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | Gpr85 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | Gpr61 | G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight. (449 aa) |
| | Gpr156 | Probable G-protein coupled receptor 156; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (798 aa) |
| | Gpr107 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). (551 aa) |
| | Tas2r143 | Taste receptor type 2 member 143; Putative taste receptor which may play a role in the perception of bitterness. (293 aa) |
| | Mrgpre | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (310 aa) |
| | Gpr101 | Probable G-protein coupled receptor 101; Orphan receptor. (511 aa) |
| | Gpr135 | G-protein coupled receptor 135; Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). (457 aa) |
| | Adgrd1 | Adhesion G-protein coupled receptor D1; Orphan receptor. Signals via G(s)-alpha family of G-proteins. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (903 aa) |
| | Mrgprg | Mas-related G-protein coupled receptor member G; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (289 aa) |
| | Gpr149 | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (732 aa) |
| | Gpr4 | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. (365 aa) |
| | Mrgprb2 | Mas-related G-protein coupled receptor member B2; Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Belongs to the G-protein coupl [...] (338 aa) |
| | Gpr82 | Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa) |
| | Tas2r139 | Taste receptor type 2 member 39; Putative taste receptor which may play a role in the perception of bitterness. (319 aa) |
| | Tpra1 | Transmembrane protein adipocyte-associated 1. (369 aa) |
| | Gpr20 | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. (358 aa) |
| | Tas2r134 | Taste receptor type 2 member 134; Putative taste receptor which may play a role in the perception of bitterness. (298 aa) |
| | Gpr173 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. (373 aa) |
| | Gpr21 | Probable G-protein coupled receptor 21; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (349 aa) |
| | Gpr141 | Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (305 aa) |
| | Tas2r107 | Taste receptor type 2 member 107; Putative taste receptor which may play a role in the perception of bitterness. (308 aa) |
| | Tas2r129 | Taste receptor type 2 member 129; Putative taste receptor which may play a role in the perception of bitterness. (320 aa) |
| | Wls | Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. (541 aa) |
| | Tas2r102 | Taste receptor type 2 member 102; Putative taste receptor which may play a role in the perception of bitterness. (347 aa) |
| | Tas2r109 | Taste receptor type 2 member 109; Putative taste receptor which may play a role in the perception of bitterness. (316 aa) |
| | Tas2r117 | Taste receptor type 2 member 117; Putative taste receptor which may play a role in the perception of bitterness. (330 aa) |
| | Tas2r135 | Taste receptor type 2 member 135; Putative taste receptor which may play a role in the perception of bitterness. (321 aa) |
| | Tas2r136 | Taste receptor type 2 member 136; Putative taste receptor which may play a role in the perception of bitterness. (327 aa) |
| | Oprl1 | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociceptio [...] (367 aa) |
| | Olfr480 | Olfactory receptor 480; Probable odorant receptor, which recognizes only aliphatic alcohols, suggesting that it may convey a 'woody' or 'sweet' sour. Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | Tas2r120 | Taste receptor type 2 member 120; Putative taste receptor which may play a role in the perception of bitterness. (295 aa) |
| | Tas2r104 | Taste receptor type 2 member 104; Putative taste receptor which may play a role in the perception of bitterness. (302 aa) |
| | Olfr508 | Olfactory receptor 508; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa) |
| | Vmn1r48 | Vomeronasal type-1 receptor 48; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (302 aa) |
| | Mrgprh | Mas-related G-protein coupled receptor member H; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (321 aa) |
| | Vmn1r53 | Vomeronasal type-1 receptor 53; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa) |
| | Tas2r125 | Taste receptor type 2 member 125; Putative taste receptor which may play a role in the perception of bitterness. (311 aa) |
| | Tas2r124 | Taste receptor type 2 member 124; Putative taste receptor which may play a role in the perception of bitterness. (309 aa) |
| | Gpr155 | G protein-coupled receptor 155. (868 aa) |
| | Tas2r138 | Taste receptor type 2 member 38; Putative taste receptor which may play a role in the perception of bitterness; Belongs to the G-protein coupled receptor T2R family. (331 aa) |
| | Tas2r106 | Taste receptor type 2 member 106; Putative taste receptor which may play a role in the perception of bitterness. (308 aa) |
| | V1ra8 | Vomeronasal type-1 receptor A8; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (279 aa) |
| | Tas2r113 | Taste receptor type 2 member 113; Putative taste receptor which may play a role in the perception of bitterness. (309 aa) |
| | Taar2 | Trace amine-associated receptor 2; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | Gpr84 | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). (396 aa) |
| | Olfr507 | Olfactory receptor 507; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (316 aa) |
| | Opn1sw | Short-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light. (346 aa) |
| | Tas2r114 | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. (309 aa) |
| | Gpr139 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. (345 aa) |
| | Gpr171 | Probable G-protein coupled receptor 171; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (319 aa) |
| | Olfr145 | Olfactory receptor 145; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa) |
| | Gpr25 | Probable G-protein coupled receptor 25; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | Olfr18 | Olfactory receptor 18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa) |
| | Gpr55 | G-protein coupled receptor 55; Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA (By similarity). Putative cannabinoid receptor (By similarity). May play a role in bone physiology by regulating osteoclast number and function (By similarity). May be involved in hyperalgesia associated with inflammatory and neuropathic pain. (327 aa) |
| | Mrgpra4 | Mas-related G-protein coupled receptor member A4; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain. (313 aa) |
| | Adgrf3 | Adhesion G-protein coupled receptor F3; Orphan receptor. (991 aa) |
| | Gpr88 | Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. (384 aa) |
| | Gpr31b | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B (By similarity). (319 aa) |
| | Olfr9 | Olfactory receptor 9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa) |
| | Taar7e | Trace amine-associated receptor 7e; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | Taar5 | Trace amine-associated receptor 5; Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. (337 aa) |
| | Taar4 | Trace amine-associated receptor 4; Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)- class of G-proteins which activate adenylate cyclase. (347 aa) |
| | Gpr179 | G protein-coupled receptor 179. (2293 aa) |
| | Mrgprb3 | Mas-related G-protein coupled receptor member B3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (312 aa) |
| | Mrgprb1 | Mas-related G-protein coupled receptor member B1; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (350 aa) |
| | Mrgprb4 | Mas-related G-protein coupled receptor member B4; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (321 aa) |
| | Mrgprb5 | Mas-related G-protein coupled receptor member B5; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (322 aa) |
| | Mrgprx1 | Mas-related G-protein coupled receptor member X1; Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception. (322 aa) |
| | Gpr157 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. Belongs to the G-protein coupled receptor 2 family. (330 aa) |
| | Gpr152 | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (511 aa) |
| | Adgrg4 | Adhesion G-protein coupled receptor G4; Orphan receptor. (216 aa) |
| | Olfr1095 | Olfactory receptor. (308 aa) |
| | Olfr154 | Olfactory receptor 154; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | Taar6 | Trace amine-associated receptor 6; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family. (345 aa) |
| | Gpr146 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | Gpr27 | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). (379 aa) |
| | Gpr182 | G-protein coupled receptor 182; Orphan receptor. (398 aa) |
| | Gpr153 | Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (631 aa) |
| | Gpr3 | G-protein coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid- beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes. Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | Gpr142 | Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa) |
| | Gpr160 | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (336 aa) |
| | Gpr75 | Probable G-protein coupled receptor 75; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. (540 aa) |
| | Adgrf5 | Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. (1348 aa) |
| | Adgrf2 | Adhesion G-protein coupled receptor F2; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (644 aa) |
| | Olfr1 | Olfactory receptor 1; Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5- trisphosphate (IP3) second messenger system (By similarity). (314 aa) |
| | Gpr137c | G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. (423 aa) |
| | Gpr35 | G-protein coupled receptor 35; Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. (307 aa) |
| | Hcar1 | Hydroxycarboxylic acid receptor 1; Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. (351 aa) |
| | Mrgpra1 | Mas-related G-protein coupled receptor member A1; Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception. (331 aa) |
| | Gpr137 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. (396 aa) |
| | Adgrg5 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). (524 aa) |
| | Gpr161 | G-protein coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] (545 aa) |
| | Gpr87 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity). (358 aa) |
| | Gpr162 | Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (588 aa) |
| | Olfr19 | Olfactory receptor 19; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa) |
| | Olfr11 | Olfactory receptor 11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa) |
| | Olfr187 | Olfactory receptor 187; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (308 aa) |
| | Olfr160 | Olfactory receptor 151; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa) |
| | Olfr1094 | Olfactory receptor 1094; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | Olfr139 | Olfactory receptor 139; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (315 aa) |
| | Olfr3 | Olfactory receptor 3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa) |
| | Olfr183 | Olfactory receptor 183; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa) |
| | Olfr146 | Olfactory receptor 146; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (306 aa) |
| | Olfr1052 | Olfactory receptor 1052; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa) |
| | Olfr1102 | Olfactory receptor 1102; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa) |
| | Olfr149 | Olfactory receptor 149; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (311 aa) |
| | Olfr24 | Olfactory receptor 24; Odorant receptor. (313 aa) |
| | Olfr10 | Olfactory receptor 10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (311 aa) |
| | Olfr958 | Olfactory receptor 958; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa) |
| | Olfr13 | Olfactory receptor 13; Odorant receptor. (310 aa) |
| | Olfr1086 | Olfactory receptor 1086; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa) |
| | Olfr1044 | Olfactory receptor 1044; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (314 aa) |
| | Olfr1444 | Olfactory receptor 1444; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (319 aa) |
| | Olfr142 | Olfactory receptor 142; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (305 aa) |
| | Olfr1020 | Olfactory receptor 1020; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (317 aa) |
| | Olfr63 | Olfactory receptor 63; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (316 aa) |
| | Olfr186 | Olfactory receptor 186; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa) |
| | Olfr867 | Olfactory receptor 867; Possible olfactory or taste receptor. Belongs to the G-protein coupled receptor 1 family. (331 aa) |
| | Olfr472 | Olfactory receptor 472; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa) |
| | Olfr1002 | Olfactory receptor 1002; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | Olfr140 | Olfactory receptor 140; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (302 aa) |
| | Olfr1009 | Olfactory receptor 1009; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (314 aa) |
| | Olfr1019 | Olfactory receptor 1019; Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). (310 aa) |
| | Olfr482 | Olfactory receptor 482; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (323 aa) |
| | Olfr15 | Olfactory receptor 15; Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT). Also binds odorants acetophenone and benzaldehyde. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons. (312 aa) |
| | Olfr148 | Olfactory receptor 148; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa) |
| | Olfr12 | Olfactory receptor 12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | Olfr481 | Olfactory receptor 481; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa) |
| | Olfr502 | Olfactory receptor 502; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (314 aa) |
| | Vmn1r43 | Vomeronasal type-1 receptor 43; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (329 aa) |
| | Vmn1r47 | Vomeronasal type-1 receptor 47; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa) |
| | Vmn1r51 | Vomeronasal type-1 receptor 51; Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (329 aa) |
| | Vmn1r46 | Vomeronasal type-1 receptor 46; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (309 aa) |
| | Vmn1r52 | Vomeronasal type-1 receptor 52; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (309 aa) |
| | Vmn1r54 | Vomeronasal type-1 receptor 54; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (315 aa) |
| | Vmn1r42 | Vomeronasal type-1 receptor 42; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (329 aa) |
| | Gpr108 | Protein GPR108; Belongs to the LU7TM family. (569 aa) |
| | Gpr22 | G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity). (469 aa) |
