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Rpl13 Rpl13 Rps11 Rps11 Rplp1 Rplp1 Rps18 Rps18 Rpl19 Rpl19 Rpl24 Rpl24 Rps6ka2 Rps6ka2 Rps6kb2 Rps6kb2 Rps26 Rps26 Rps3a1 Rps3a1 Rpl6 Rpl6 Rpl28 Rpl28 Rps3 Rps3 Rps6ka3 Rps6ka3 Rps4x Rps4x Rpl4 Rpl4 Rpsa Rpsa Rps29 Rps29 Rpl21 Rpl21 Rpl37 Rpl37 Rpl10a Rpl10a Rps23 Rps23 Rpl18a Rpl18a Rps21 Rps21 Rpl37a Rpl37a Rps27rt Rps27rt Rps15 Rps15 Rpl7 Rpl7 Rps7 Rps7 Rpl15 Rpl15 Rps25 Rps25 Rpl36 Rpl36 Rps17 Rps17 Rpl35 Rpl35 Rpl3 Rpl3 Rpl10 Rpl10 Rplp0 Rplp0 Rpl31 Rpl31 Rpl34 Rpl34 Rps2 Rps2 Rpl23a Rpl23a Rpl11 Rpl11 Rps8 Rps8 Rps6 Rps6 Rps27a Rps27a Rpl7a Rpl7a Rps6ka1 Rps6ka1 Rpl38 Rpl38 Rpl27 Rpl27 Rps16 Rps16 Rps19 Rps19 Rps5 Rps5 Rpl30 Rpl30 Rpl36al Rpl36al Rpl9 Rpl9 Rps10 Rps10 Rpl35a Rpl35a Rpl39 Rpl39 Rpl13a Rpl13a Rpl12 Rpl12 Rpl29 Rpl29 Rpl22 Rpl22 Rps15a Rps15a Rps20 Rps20 Rpl27a Rpl27a Rps13 Rps13 Rpl26 Rpl26 Rps28 Rps28 Fau Fau Rpl32 Rpl32 Rpl18 Rpl18 Rps12 Rps12 Rps24 Rps24 Rpl8 Rpl8 Rpl17 Rpl17 Rps14 Rps14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rpl1360S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa)
Rps1140S ribosomal protein S11. (158 aa)
Rplp160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
Rps1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
Rpl1960S ribosomal protein L19. (196 aa)
Rpl2460S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
Rps6ka2Ribosomal protein S6 kinase alpha-2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity). (733 aa)
Rps6kb2Ribosomal protein S6 kinase beta-2; Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. (485 aa)
Rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
Rps3a140S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
Rpl660S ribosomal protein L6; Component of the large ribosomal subunit. (296 aa)
Rpl2860S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (137 aa)
Rps340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa)
Rps6ka3Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...] (740 aa)
Rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
Rpl460S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (419 aa)
Rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
Rps2940S ribosomal protein S29. (56 aa)
Rpl2160S ribosomal protein L21; Component of the large ribosomal subunit. (160 aa)
Rpl3760S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
Rpl10a60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. (217 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Rpl18a60S ribosomal protein L18a. (176 aa)
Rps2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
Rpl37a60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family. (92 aa)
Rps27rt40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
Rps1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
Rpl760S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (270 aa)
Rps740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
Rpl1560S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
Rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
Rpl3660S ribosomal protein L36; Component of the large ribosomal subunit. (105 aa)
Rps1740S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family. (135 aa)
Rpl3560S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family. (123 aa)
Rpl360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
Rpl1060S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. (214 aa)
Rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
Rpl3160S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (125 aa)
Rpl3460S ribosomal protein L34; Component of the large ribosomal subunit. (117 aa)
Rps240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (293 aa)
Rpl23a60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. (156 aa)
Rpl1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa)
Rps840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
Rps640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Rpl7a60S ribosomal protein L7a. (266 aa)
Rps6ka1Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...] (735 aa)
Rpl3860S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
Rpl2760S ribosomal protein L27; Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). (136 aa)
Rps1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
Rps1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
Rps540S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. (204 aa)
Rpl3060S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family. (115 aa)
Rpl36al60S ribosomal protein L36a. (106 aa)
Rpl960S ribosomal protein L9; Belongs to the universal ribosomal protein uL6 family. (192 aa)
Rps1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
Rpl35a60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
Rpl3960S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
Rpl13a60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as cerupla [...] (203 aa)
Rpl1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
Rpl2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (160 aa)
Rpl2260S ribosomal protein L22. (128 aa)
Rps15a40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
Rps2040S ribosomal protein S20. (119 aa)
Rpl27a60S ribosomal protein L27a. (148 aa)
Rps1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Rpl2660S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
Rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
FauUbiquitin-like protein FUBI; Belongs to the ubiquitin family. (133 aa)
Rpl3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
Rpl1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
Rps1240S ribosomal protein S12. (132 aa)
Rps2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. (133 aa)
Rpl860S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. (257 aa)
Rpl1760S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family. (184 aa)
Rps1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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