STRINGSTRING
Adora3 Adora3 Smo Smo Tmigd3 Tmigd3 Celsr1 Celsr1 Gpr132 Gpr132 Drd1 Drd1 Htr1a Htr1a Celsr3 Celsr3 Adgrf4 Adgrf4 Gabbr1 Gabbr1 Gpr143 Gpr143 Pth2r Pth2r Gpr39 Gpr39 Gpr37l1 Gpr37l1 Tacr3 Tacr3 Tas1r1 Tas1r1 Gpr165 Gpr165 Ednra Ednra Irx6 Irx6 Gpr83 Gpr83 Vipr1 Vipr1 Grm1 Grm1 Olfr1353 Olfr1353 Drd5 Drd5 Adrb1 Adrb1 Trhr2 Trhr2 Gpr34 Gpr34 Ackr1 Ackr1 Ltb4r2 Ltb4r2 Vmn2r107 Vmn2r107 Olfr6 Olfr6 S1pr1 S1pr1 Sstr5 Sstr5 Vmn1r45 Vmn1r45 Mtnr1b Mtnr1b S1pr2 S1pr2 Fzd9 Fzd9 Mc4r Mc4r Cnr1 Cnr1 Fzd1 Fzd1 Ghsr Ghsr Adrb2 Adrb2 Ccr10 Ccr10 Fzd5 Fzd5 Casr Casr Olfr25 Olfr25 Oprl1 Oprl1 Olfr46 Olfr46 Vmn1r48 Vmn1r48 Vmn1r63 Vmn1r63 Mrgprh Mrgprh Calcr Calcr Drd2 Drd2 Adgre5 Adgre5 Vmn1r53 Vmn1r53 Olfr44 Olfr44 V1ra8 V1ra8 Vmn1r171 Vmn1r171 Gpr84 Gpr84 Olfr586 Olfr586 Vmn1r65 Vmn1r65 Adora1 Adora1 Olfr18 Olfr18 Htr1d Htr1d Gpr88 Gpr88 Celsr2 Celsr2 Olfr9 Olfr9 Fzd2 Fzd2 Olfr382 Olfr382 Vmn2r32 Vmn2r32 Olfr154 Olfr154 Gpr146 Gpr146 Ccr7 Ccr7 Olfr26 Olfr26 Oprm1 Oprm1 Vmn1r58 Vmn1r58 Cysltr1 Cysltr1 Fzd7 Fzd7 Olfr1 Olfr1 S1pr5 S1pr5 Oprk1 Oprk1 Vmn1r56 Vmn1r56 Vmn2r104 Vmn2r104 Rrh Rrh Olfr138 Olfr138 Vmn1r172 Vmn1r172 Vmn1r62 Vmn1r62 Vmn1r25 Vmn1r25 Vmn1r148 Vmn1r148 Adgrg1 Adgrg1 Xcr1 Xcr1 Olfr57 Olfr57 Prokr1 Prokr1 Gpr162 Gpr162 Olfr19 Olfr19 Olfr403 Olfr403 Olfr43 Olfr43 Olfr11 Olfr11 Olfr2 Olfr2 Olfr5 Olfr5 Olfr61 Olfr61 Olfr8 Olfr8 Olfr30 Olfr30 Olfr59 Olfr59 Olfr642 Olfr642 Olfr31 Olfr31 Olfr395 Olfr395 Olfr3 Olfr3 Olfr45 Olfr45 Olfr394 Olfr394 Olfr33 Olfr33 Olfr50 Olfr50 Olfr62 Olfr62 Olfr24 Olfr24 Olfr10 Olfr10 Olfr263 Olfr263 Olfr13 Olfr13 Olfr412 Olfr412 Olfr27 Olfr27 Olfr52 Olfr52 Olfr397 Olfr397 Olfr32 Olfr32 Olfr410 Olfr410 Olfr58 Olfr58 Olfr48 Olfr48 Olfr23 Olfr23 Olfr60 Olfr60 Olfr54 Olfr54 Olfr161 Olfr161 Olfr12 Olfr12 Olfr51 Olfr51 Olfr402 Olfr402 Olfr47 Olfr47 Olfr701 Olfr701 Vmn1r43 Vmn1r43 Vmn1r47 Vmn1r47 Vmn1r51 Vmn1r51 Vmn1r40 Vmn1r40 Vmn1r44 Vmn1r44 Vmn1r46 Vmn1r46 Vmn1r10 Vmn1r10 Vmn1r15 Vmn1r15 Vmn1r52 Vmn1r52 Vmn1r41 Vmn1r41 Vmn1r54 Vmn1r54 Vmn1r13 Vmn1r13 Vmn1r42 Vmn1r42 Vmn1r49 Vmn1r49 Vmn1r14 Vmn1r14 Vmn1r50 Vmn1r50 Vmn1r11 Vmn1r11 Vmn1r29 Vmn1r29
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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Adora3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. (319 aa)
SmoSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. (793 aa)
Tmigd3Transmembrane domain-containing protein TMIGD3. (209 aa)
Celsr1Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (3034 aa)
Gpr132Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensin [...] (382 aa)
Drd1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
Htr1a5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] (421 aa)
Celsr3Cadherin EGF LAG seven-pass G-type receptor 3; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (3301 aa)
Adgrf4Adhesion G protein-coupled receptor F4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (698 aa)
Gabbr1Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] (960 aa)
Gpr143G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. (405 aa)
Pth2rParathyroid hormone 2 receptor; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). (546 aa)
Gpr39G-protein coupled receptor 39; Zn(2+) acts as an agonist (By similarity). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death; Belongs to the G-protein coupled receptor 1 family. (456 aa)
Gpr37l1G-protein coupled receptor 37-like 1; G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh path [...] (481 aa)
Tacr3Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (452 aa)
Tas1r1Taste receptor type 1 member 1; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. (842 aa)
Gpr165G-protein coupled receptor 165; Belongs to the G-protein coupled receptor 1 family. (455 aa)
EdnraEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
Irx6Iroquois-class homeodomain protein IRX-6. (439 aa)
Gpr83Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor. (423 aa)
Vipr1Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 2 family. (459 aa)
Grm1Metabotropic glutamate receptor 1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina. (1199 aa)
Olfr1353Olfactory receptor. (309 aa)
Drd5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
Adrb1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors. (466 aa)
Trhr2Thyrotropin-releasing hormone receptor 2; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Gpr34Probable G-protein coupled receptor 34; Orphan receptor. (375 aa)
Ackr1Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] (334 aa)
Ltb4r2Leukotriene B4 receptor 2; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (360 aa)
Vmn2r107Vomeronasal 2, receptor 107. (861 aa)
Olfr6Olfactory receptor 6; Odorant receptor. (316 aa)
S1pr1Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal emb [...] (382 aa)
Sstr5Somatostatin receptor type 5; Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. (362 aa)
Vmn1r45Vomeronasal type-1 receptor 45; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (318 aa)
Mtnr1bMelatonin receptor type 1B; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity); Belongs to the G-protein coupled receptor 1 family. (364 aa)
S1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (By similarity). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (By similarity). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (352 aa)
Fzd9Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell [...] (592 aa)
Mc4rMelanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). (332 aa)
Cnr1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upo [...] (473 aa)
Fzd1Frizzled-1; Receptor for Wnt proteins. Activated by WNT7B. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calciu [...] (642 aa)
GhsrGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity). (364 aa)
Adrb2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. (418 aa)
Ccr10C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level. (362 aa)
Fzd5Frizzled-5; Receptor for Wnt proteins. Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed. In neurons, activation of WNT7A promotes formation of synapses (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium [...] (585 aa)
CasrExtracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino [...] (1079 aa)
Olfr25Olfactory receptor. (313 aa)
Oprl1Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociceptio [...] (367 aa)
Olfr46Olfactory receptor. (318 aa)
Vmn1r48Vomeronasal type-1 receptor 48; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (302 aa)
Vmn1r63Vomeronasal type-1 receptor. (300 aa)
MrgprhMas-related G-protein coupled receptor member H; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (321 aa)
CalcrCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin; Belongs to the G-protein coupled receptor 2 family. (533 aa)
Drd2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Adgre5CD97 antigen subunit alpha; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. (818 aa)
Vmn1r53Vomeronasal type-1 receptor 53; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa)
Olfr44Olfactory receptor. (314 aa)
V1ra8Vomeronasal type-1 receptor A8; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (279 aa)
Vmn1r171Vomeronasal type-1 receptor. (316 aa)
Gpr84G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). (396 aa)
Olfr586Olfactory receptor. (317 aa)
Vmn1r65Vomeronasal type-1 receptor. (332 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (326 aa)
Olfr18Olfactory receptor 18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
Htr1d5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (374 aa)
Gpr88Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. (384 aa)
Celsr2Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation. (2919 aa)
Olfr9Olfactory receptor 9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
Fzd2Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] (570 aa)
Olfr382Olfactory receptor. (312 aa)
Vmn2r32Vomeronasal 2, receptor 32. (852 aa)
Olfr154Olfactory receptor 154; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa)
Gpr146Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (333 aa)
Ccr7C-C chemokine receptor type 7; Receptor for the MIP-3-beta chemokine. (378 aa)
Olfr26Olfactory receptor. (308 aa)
Oprm1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (438 aa)
Vmn1r58Vomeronasal type-1 receptor. (310 aa)
Cysltr1Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. (352 aa)
Fzd7Frizzled-7; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to invo [...] (572 aa)
Olfr1Olfactory receptor 1; Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5- trisphosphate (IP3) second messenger system (By similarity). (314 aa)
S1pr5Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling p [...] (400 aa)
Oprk1Kappa-type opioid receptor; G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by r [...] (380 aa)
Vmn1r56Vomeronasal type-1 receptor. (310 aa)
Vmn2r104Vomeronasal 2, receptor 104. (860 aa)
RrhVisual pigment-like receptor peropsin; May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds. (337 aa)
Olfr138Olfactory receptor. (312 aa)
Vmn1r172Vomeronasal type-1 receptor. (313 aa)
Vmn1r62Vomeronasal type-1 receptor. (300 aa)
Vmn1r25Vomeronasal type-1 receptor. (302 aa)
Vmn1r148Taste receptor type 2. (307 aa)
Adgrg1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoie [...] (687 aa)
Xcr1Chemokine XC receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable). (322 aa)
Olfr57Olfactory receptor. (319 aa)
Prokr1Prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity). (393 aa)
Gpr162Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. (588 aa)
Olfr19Olfactory receptor 19; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa)
Olfr403Olfactory receptor Olfr403. (313 aa)
Olfr43Olfactory receptor Olfr43. (313 aa)
Olfr11Olfactory receptor 11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
Olfr2Olfactory receptor. (327 aa)
Olfr5Olfactory receptor 5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
Olfr61Olfactory receptor. (311 aa)
Olfr8Olfactory receptor 8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa)
Olfr30Olfactory receptor. (315 aa)
Olfr59Olfactory receptor. (323 aa)
Olfr642Olfactory receptor. (314 aa)
Olfr31Olfactory receptor. (317 aa)
Olfr395Olfactory receptor. (312 aa)
Olfr3Olfactory receptor 3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
Olfr45Olfactory receptor. (311 aa)
Olfr394Olfactory receptor. (310 aa)
Olfr33Olfactory receptor. (318 aa)
Olfr50Olfactory receptor 50; Odorant receptor. Activated by (+) and (-)-carvone. Belongs to the G-protein coupled receptor 1 family. (312 aa)
Olfr62Olfactory receptor 62. (315 aa)
Olfr24Olfactory receptor 24; Odorant receptor. (313 aa)
Olfr10Olfactory receptor 10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (311 aa)
Olfr263Olfactory receptor. (317 aa)
Olfr13Olfactory receptor 13; Odorant receptor. (310 aa)
Olfr412Olfactory receptor. (312 aa)
Olfr27Olfactory receptor. (311 aa)
Olfr52Olfactory receptor. (319 aa)
Olfr397Olfactory receptor. (315 aa)
Olfr32Olfactory receptor. (308 aa)
Olfr410Olfactory receptor. (315 aa)
Olfr58Olfactory receptor. (309 aa)
Olfr48Olfactory receptor. (301 aa)
Olfr23Olfactory receptor. (325 aa)
Olfr60Olfactory receptor. (311 aa)
Olfr54Olfactory receptor. (313 aa)
Olfr161Olfactory receptor. (313 aa)
Olfr12Olfactory receptor 12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (333 aa)
Olfr51Olfactory receptor. (307 aa)
Olfr402Olfactory receptor. (315 aa)
Olfr47Olfactory receptor. (321 aa)
Olfr701Olfactory receptor MOR283-1. (316 aa)
Vmn1r43Vomeronasal type-1 receptor 43; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (329 aa)
Vmn1r47Vomeronasal type-1 receptor 47; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa)
Vmn1r51Vomeronasal type-1 receptor 51; Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (329 aa)
Vmn1r40Vomeronasal type-1 receptor 40; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa)
Vmn1r44Vomeronasal type-1 receptor 44; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (310 aa)
Vmn1r46Vomeronasal type-1 receptor 46; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (309 aa)
Vmn1r10Vomeronasal type-1 receptor. (311 aa)
Vmn1r15Vomeronasal type-1 receptor. (299 aa)
Vmn1r52Vomeronasal type-1 receptor 52; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (309 aa)
Vmn1r41Vomeronasal type-1 receptor 41; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (311 aa)
Vmn1r54Vomeronasal type-1 receptor 54; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (315 aa)
Vmn1r13Vomeronasal type-1 receptor. (300 aa)
Vmn1r42Vomeronasal type-1 receptor 42; Putative pheromone receptor implicated in the regulation of social and reproductive behavior. (329 aa)
Vmn1r49Vomeronasal type-1 receptor 49; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (310 aa)
Vmn1r14Vomeronasal type-1 receptor. (303 aa)
Vmn1r50Vomeronasal type-1 receptor 50; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family. (310 aa)
Vmn1r11Vomeronasal type-1 receptor. (299 aa)
Vmn1r29Vomeronasal type-1 receptor. (303 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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