(23 nodes) Amyloid-beta clearance network (Mus pahari)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Igf1r	Insulin-like growth factor 1 receptor isoform X1. (1373 aa)
	Lrp1	Low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor). (4545 aa)
	Mme	Neprilysin. (750 aa)
	Lrp4	Low-density lipoprotein receptor-related protein 4. (1903 aa)
	Lrp2	Low-density lipoprotein receptor-related protein 2. (4660 aa)
	Cd36	Platelet glycoprotein 4 isoform X1. (472 aa)
	Insr	Insulin receptor isoform X1. (1372 aa)
	C5ar1	C5a anaphylatoxin chemotactic receptor 1. (352 aa)
	C3	Complement component 3. (1663 aa)
	Rab5a	Ras-related protein Rab-5A. (187 aa)
	Trem2	Triggering receptor expressed on myeloid cells 2 isoform X1. (249 aa)
	Rab11b	Ras-related protein Rab-11B. (218 aa)
	Cltc	Clathrin heavy chain 1 isoform X1. (1679 aa)
	Lrpap1	Alpha-2-macroglobulin receptor-associated protein. (360 aa)
	Rab11a	Ras-related protein Rab-11A. (216 aa)
	Ldlr	Low-density lipoprotein receptor isoform X1. (861 aa)
	Ide	Insulin-degrading enzyme isoform X1. (986 aa)
	MGP_PahariEiJ_P0019398	annotation not available (1149 aa)
	Marco	Macrophage receptor with collagenous structure. (516 aa)
	Itgb2	Integrin beta 2. (770 aa)
	Abca7	ATP-binding cassette sub-family A member 7 isoform X1. (2167 aa)
	Itgam	Integrin alpha-M isoform X1. (1153 aa)
	Picalm	Phosphatidylinositol-binding clathrin assembly protein isoform X1. (660 aa)

Your Current Organism:

Mus pahari

NCBI taxonomy Id: 10093
Other names: Coelomys parahi, M. pahari, shrew mouse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca7	Picalm	MGP_PahariEiJ_P0086969	MGP_PahariEiJ_P0017472	ATP-binding cassette sub-family A member 7 isoform X1.	Phosphatidylinositol-binding clathrin assembly protein isoform X1.	0.723
Abca7	Trem2	MGP_PahariEiJ_P0086969	MGP_PahariEiJ_P0044695	ATP-binding cassette sub-family A member 7 isoform X1.	Triggering receptor expressed on myeloid cells 2 isoform X1.	0.645
C3	C5ar1	MGP_PahariEiJ_P0044920	MGP_PahariEiJ_P0045891	Complement component 3.	C5a anaphylatoxin chemotactic receptor 1.	0.712
C3	Itgam	MGP_PahariEiJ_P0044920	MGP_PahariEiJ_P0019395	Complement component 3.	Integrin alpha-M isoform X1.	0.977
C3	Itgb2	MGP_PahariEiJ_P0044920	MGP_PahariEiJ_P0086723	Complement component 3.	Integrin beta 2.	0.954
C3	MGP_PahariEiJ_P0019398	MGP_PahariEiJ_P0044920	MGP_PahariEiJ_P0019398	Complement component 3.	annotation not available	0.786
C5ar1	C3	MGP_PahariEiJ_P0045891	MGP_PahariEiJ_P0044920	C5a anaphylatoxin chemotactic receptor 1.	Complement component 3.	0.712
C5ar1	Itgam	MGP_PahariEiJ_P0045891	MGP_PahariEiJ_P0019395	C5a anaphylatoxin chemotactic receptor 1.	Integrin alpha-M isoform X1.	0.558
C5ar1	MGP_PahariEiJ_P0019398	MGP_PahariEiJ_P0045891	MGP_PahariEiJ_P0019398	C5a anaphylatoxin chemotactic receptor 1.	annotation not available	0.558
Cd36	Itgam	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0019395	Platelet glycoprotein 4 isoform X1.	Integrin alpha-M isoform X1.	0.660
Cd36	Itgb2	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0086723	Platelet glycoprotein 4 isoform X1.	Integrin beta 2.	0.679
Cd36	Lrp1	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0087618	Platelet glycoprotein 4 isoform X1.	Low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor).	0.654
Cd36	MGP_PahariEiJ_P0019398	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0019398	Platelet glycoprotein 4 isoform X1.	annotation not available	0.660
Cd36	Picalm	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0017472	Platelet glycoprotein 4 isoform X1.	Phosphatidylinositol-binding clathrin assembly protein isoform X1.	0.405
Cd36	Trem2	MGP_PahariEiJ_P0048188	MGP_PahariEiJ_P0044695	Platelet glycoprotein 4 isoform X1.	Triggering receptor expressed on myeloid cells 2 isoform X1.	0.443
Cltc	Ldlr	MGP_PahariEiJ_P0035729	MGP_PahariEiJ_P0022639	Clathrin heavy chain 1 isoform X1.	Low-density lipoprotein receptor isoform X1.	0.459
Cltc	Lrp1	MGP_PahariEiJ_P0035729	MGP_PahariEiJ_P0087618	Clathrin heavy chain 1 isoform X1.	Low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor).	0.425
Cltc	Lrp2	MGP_PahariEiJ_P0035729	MGP_PahariEiJ_P0063110	Clathrin heavy chain 1 isoform X1.	Low-density lipoprotein receptor-related protein 2.	0.484
Cltc	Lrp4	MGP_PahariEiJ_P0035729	MGP_PahariEiJ_P0064076	Clathrin heavy chain 1 isoform X1.	Low-density lipoprotein receptor-related protein 4.	0.484
Cltc	Picalm	MGP_PahariEiJ_P0035729	MGP_PahariEiJ_P0017472	Clathrin heavy chain 1 isoform X1.	Phosphatidylinositol-binding clathrin assembly protein isoform X1.	0.928