(33 nodes) Activation of the pre-replicative complex, and GINS complex network (Mus spretus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mcmdc2	Minichromosome maintenance domain containing 2. (694 aa)
	Mcm3	Minichromosome maintenance complex component 3. (812 aa)
	Orc2	Origin recognition complex, subunit 2. (576 aa)
	Mcm6	Minichromosome maintenance complex component 6. (821 aa)
	Timeless	Timeless circadian clock 1. (1198 aa)
	Cdc6	Cell division cycle 6. (562 aa)
	Gmnn	Geminin. (206 aa)
	Wdhd1	WD repeat and HMG-box DNA binding protein 1. (1118 aa)
	Tonsl	Tonsoku-like, DNA repair protein. (1363 aa)
	Mcm4	Minichromosome maintenance complex component 4. (862 aa)
	Cdc45	Cell division cycle 45. (566 aa)
	Tm4sf19	Transmembrane 4 L six family member 19. (206 aa)
	Piezo2	Piezo-type mechanosensitive ion channel component 2. (2824 aa)
	Mcm10	Minichromosome maintenance 10 replication initiation factor. (886 aa)
	Orc4	Origin recognition complex, subunit 4. (433 aa)
	Mcm8	Minichromosome maintenance 8 homologous recombination repair factor. (833 aa)
	Gins1	GINS complex subunit 1 (Psf1 homolog). (196 aa)
	Mms22l	MMS22-like, DNA repair protein. (1234 aa)
	Orc3	Origin recognition complex, subunit 3. (718 aa)
	Orc1	Origin recognition complex, subunit 1. (846 aa)
	Orc5	Origin recognition complex, subunit 5. (435 aa)
	Cdc7	Cell division cycle 7 (S. cerevisiae). (563 aa)
	Eln	Elastin. (841 aa)
	Mcm7	Minichromosome maintenance complex component 7. (719 aa)
	Mcm2	Minichromosome maintenance complex component 2. (904 aa)
	Mcmbp	Minichromosome maintenance complex binding protein. (642 aa)
	Gins4	GINS complex subunit 4 (Sld5 homolog). (223 aa)
	Mcm5	Minichromosome maintenance complex component 5. (734 aa)
	Orc6	Origin recognition complex, subunit 6. (262 aa)
	Gins3	GINS complex subunit 3 (Psf3 homolog). (216 aa)
	Gins2	GINS complex subunit 2 (Psf2 homolog). (185 aa)
	Piezo1	Piezo-type mechanosensitive ion channel component 1. (2546 aa)
	Cdt1	Chromatin licensing and DNA replication factor 1. (557 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdc45	Cdc6	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0031146	Cell division cycle 45.	Cell division cycle 6.	0.986
Cdc45	Cdc7	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0072173	Cell division cycle 45.	Cell division cycle 7 (S. cerevisiae).	0.950
Cdc45	Cdt1	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0089903	Cell division cycle 45.	Chromatin licensing and DNA replication factor 1.	0.976
Cdc45	Eln	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0073978	Cell division cycle 45.	Elastin.	0.875
Cdc45	Gins1	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0057278	Cell division cycle 45.	GINS complex subunit 1 (Psf1 homolog).	0.998
Cdc45	Gins2	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0089768	Cell division cycle 45.	GINS complex subunit 2 (Psf2 homolog).	0.999
Cdc45	Gins3	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0089174	Cell division cycle 45.	GINS complex subunit 3 (Psf3 homolog).	0.999
Cdc45	Gins4	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0087447	Cell division cycle 45.	GINS complex subunit 4 (Sld5 homolog).	0.999
Cdc45	Gmnn	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0035515	Cell division cycle 45.	Geminin.	0.650
Cdc45	Mcm10	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0051425	Cell division cycle 45.	Minichromosome maintenance 10 replication initiation factor.	0.999
Cdc45	Mcm2	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0077944	Cell division cycle 45.	Minichromosome maintenance complex component 2.	0.999
Cdc45	Mcm3	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0017862	Cell division cycle 45.	Minichromosome maintenance complex component 3.	0.999
Cdc45	Mcm4	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0042352	Cell division cycle 45.	Minichromosome maintenance complex component 4.	0.999
Cdc45	Mcm5	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0088553	Cell division cycle 45.	Minichromosome maintenance complex component 5.	0.999
Cdc45	Mcm6	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0020674	Cell division cycle 45.	Minichromosome maintenance complex component 6.	0.999
Cdc45	Mcm7	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0074456	Cell division cycle 45.	Minichromosome maintenance complex component 7.	0.999
Cdc45	Mcm8	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0056939	Cell division cycle 45.	Minichromosome maintenance 8 homologous recombination repair factor.	0.974
Cdc45	Mcmbp	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0086093	Cell division cycle 45.	Minichromosome maintenance complex binding protein.	0.692
Cdc45	Mcmdc2	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0017641	Cell division cycle 45.	Minichromosome maintenance domain containing 2.	0.970
Cdc45	Orc1	MGP_SPRETEiJ_P0042691	MGP_SPRETEiJ_P0065979	Cell division cycle 45.	Origin recognition complex, subunit 1.	0.993