(72 nodes) DNA replication network (Mus spretus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Gen1	GEN1, Holliday junction 5' flap endonuclease. (908 aa)
	Mcmdc2	Minichromosome maintenance domain containing 2. (694 aa)
	Mcm3	Minichromosome maintenance complex component 3. (812 aa)
	Prim2	DNA primase, p58 subunit. (505 aa)
	Ppil3	Peptidylprolyl isomerase (cyclophilin)-like 3. (161 aa)
	Mcm6	Minichromosome maintenance complex component 6. (821 aa)
	Tor3a	Torsin family 3, member A. (385 aa)
	Gtf3c6	General transcription factor IIIC, polypeptide 6, alpha. (227 aa)
	Fam162b	Family with sequence similarity 162, member B. (157 aa)
	Dna2	DNA replication helicase/nuclease 2. (1062 aa)
	Prim1	DNA primase, p49 subunit. (418 aa)
	Pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa)
	Rpa1	Replication protein A1. (645 aa)
	Atad5	ATPase family, AAA domain containing 5. (1826 aa)
	Rnaseh1	Ribonuclease H1. (285 aa)
	MGP_SPRETEiJ_P0033897	annotation not available (527 aa)
	Wrnip1	Werner helicase interacting protein 1. (660 aa)
	Rad17	RAD17 checkpoint clamp loader component. (688 aa)
	Cpne6	Copine VI. (557 aa)
	MGP_SPRETEiJ_P0038793	annotation not available (65 aa)
	Chrac1	Chromatin accessibility complex 1. (130 aa)
	Cpne8	Copine VIII. (577 aa)
	Mcm4	Minichromosome maintenance complex component 4. (862 aa)
	Rfc4	Replication factor C (activator 1) 4. (364 aa)
	Tm4sf19	Transmembrane 4 L six family member 19. (206 aa)
	Parp14	Poly (ADP-ribose) polymerase family, member 14. (1816 aa)
	Parp9	Poly (ADP-ribose) polymerase family, member 9. (830 aa)
	Fam162a	Family with sequence similarity 162, member A. (155 aa)
	Meiob	Meiosis specific with OB domains. (470 aa)
	Cpne5	Copine V. (593 aa)
	Yju2	YJU2 splicing factor. (314 aa)
	MGP_SPRETEiJ_P0049432	annotation not available (107 aa)
	MGP_SPRETEiJ_P0049604	annotation not available (87 aa)
	Pola2	Polymerase (DNA directed), alpha 2. (600 aa)
	Macrod1	mono-ADP ribosylhydrolase 1. (323 aa)
	Fen1	Flap structure specific endonuclease 1. (380 aa)
	Stn1	STN1, CST complex subunit. (378 aa)
	Tor4a	Torsin family 4, member A. (426 aa)
	Tor1b	Torsin family 1, member B. (336 aa)
	Tor1a	Torsin family 1, member A (torsin A). (333 aa)
	Tor2a	Torsin family 2, member A. (321 aa)
	Pcna	Proliferating cell nuclear antigen. (261 aa)
	Macrod2	mono-ADP ribosylhydrolase 2. (459 aa)
	Cpne1	Copine I. (536 aa)
	Gdap2	Ganglioside-induced differentiation-associated-protein 2. (546 aa)
	Sass6	SAS-6 centriolar assembly protein. (654 aa)
	Cpne3	Copine III. (533 aa)
	Rpa2	Replication protein A2. (270 aa)
	Rfc1	Replication factor C (activator 1) 1. (1145 aa)
	Pole	Polymerase (DNA directed), epsilon. (2283 aa)
	Rfc5	Replication factor C (activator 1) 5. (339 aa)
	Rfc2	Replication factor C (activator 1) 2. (350 aa)
	Prkrip1	Prkr interacting protein 1 (IL11 inducible). (186 aa)
	Mcm7	Minichromosome maintenance complex component 7. (719 aa)
	Rfc3	Replication factor C (activator 1) 3. (356 aa)
	Rpa3	Replication protein A3. (121 aa)
	Ssbp1	Single-stranded DNA binding protein 1. (153 aa)
	Pole4	Polymerase (DNA-directed), epsilon 4 (p12 subunit). (119 aa)
	Mcm2	Minichromosome maintenance complex component 2. (904 aa)
	Cpne9	Copine family member IX. (553 aa)
	Lig1	Ligase I, DNA, ATP-dependent. (931 aa)
	Cabp5	Calcium binding protein 5. (178 aa)
	Pold1	Polymerase (DNA directed), delta 1, catalytic subunit. (1105 aa)
	Pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (461 aa)
	Mcm5	Minichromosome maintenance complex component 5. (734 aa)
	Rnaseh2a	Ribonuclease H2, large subunit. (301 aa)
	Cpne2	Copine II. (548 aa)
	D230025D16Rik	RIKEN cDNA D230025D16 gene. (422 aa)
	Cpne7	Copine VII. (557 aa)
	Exoc8	Exocyst complex component 8. (716 aa)
	Cpne4	Copine IV. (557 aa)
	MGP_SPRETEiJ_P0095866	annotation not available (1420 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atad5	Dna2	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0024294	ATPase family, AAA domain containing 5.	DNA replication helicase/nuclease 2.	0.892
Atad5	Fen1	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0050085	ATPase family, AAA domain containing 5.	Flap structure specific endonuclease 1.	0.939
Atad5	Gen1	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0033384	ATPase family, AAA domain containing 5.	GEN1, Holliday junction 5' flap endonuclease.	0.725
Atad5	Lig1	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0080766	ATPase family, AAA domain containing 5.	Ligase I, DNA, ATP-dependent.	0.835
Atad5	MGP_SPRETEiJ_P0033897	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0033897	ATPase family, AAA domain containing 5.	annotation not available	0.820
Atad5	MGP_SPRETEiJ_P0095866	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0095866	ATPase family, AAA domain containing 5.	annotation not available	0.865
Atad5	Mcm2	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0077944	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 2.	0.892
Atad5	Mcm3	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0017862	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 3.	0.410
Atad5	Mcm4	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0042352	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 4.	0.808
Atad5	Mcm5	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0088553	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 5.	0.578
Atad5	Mcm6	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0020674	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 6.	0.715
Atad5	Mcm7	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0074456	ATPase family, AAA domain containing 5.	Minichromosome maintenance complex component 7.	0.724
Atad5	Meiob	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0045035	ATPase family, AAA domain containing 5.	Meiosis specific with OB domains.	0.801
Atad5	Pcna	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0056901	ATPase family, AAA domain containing 5.	Proliferating cell nuclear antigen.	0.973
Atad5	Pola2	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0049658	ATPase family, AAA domain containing 5.	Polymerase (DNA directed), alpha 2.	0.867
Atad5	Pold1	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0082643	ATPase family, AAA domain containing 5.	Polymerase (DNA directed), delta 1, catalytic subunit.	0.821
Atad5	Pold2	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0026889	ATPase family, AAA domain containing 5.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.701
Atad5	Pole	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0072396	ATPase family, AAA domain containing 5.	Polymerase (DNA directed), epsilon.	0.879
Atad5	Pole4	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0077343	ATPase family, AAA domain containing 5.	Polymerase (DNA-directed), epsilon 4 (p12 subunit).	0.714
Atad5	Prim1	MGP_SPRETEiJ_P0030078	MGP_SPRETEiJ_P0026368	ATPase family, AAA domain containing 5.	DNA primase, p49 subunit.	0.809