(134 nodes) Sphingolipid signaling pathway network (Mus spretus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGP_SPRETEiJ_P0042929	annotation not available (133 aa)
	Eras	ES cell-expressed Ras. (227 aa)
	MGP_SPRETEiJ_P0094370	annotation not available (85 aa)
	Gnai2	Guanine nucleotide binding protein (G protein), alpha inhibiting 2. (355 aa)
	Ppp2r3a	Protein phosphatase 2, regulatory subunit B'', alpha. (1150 aa)
	Pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta. (1064 aa)
	Map2k1	Mitogen-activated protein kinase kinase 1. (393 aa)
	Ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta. (694 aa)
	S1pr5	Sphingosine-1-phosphate receptor 5. (400 aa)
	S1pr2	Sphingosine-1-phosphate receptor 2. (352 aa)
	Tradd	TNFRSF1A-associated via death domain. (310 aa)
	Pik3r2	Phosphoinositide-3-kinase regulatory subunit 2. (722 aa)
	Asah1	N-acylsphingosine amidohydrolase 1. (394 aa)
	Ppp2cb	Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform. (309 aa)
	Tpte	Transmembrane phosphatase with tensin homology. (670 aa)
	Cers4	Ceramide synthase 4. (393 aa)
	MGP_SPRETEiJ_P0086762	annotation not available (410 aa)
	Ifitm10	Interferon induced transmembrane protein 10. (201 aa)
	Hras	Harvey rat sarcoma virus oncogene. (189 aa)
	Ifitm3	Interferon induced transmembrane protein 3. (137 aa)
	Ifitm1	Interferon induced transmembrane protein 1. (106 aa)
	Ppp2r2d	Protein phosphatase 2, regulatory subunit B, delta. (453 aa)
	Mapk3	Mitogen-activated protein kinase 3. (380 aa)
	Prkcb	Protein kinase C, beta. (673 aa)
	Smpd1	Sphingomyelin phosphodiesterase 1, acid lysosomal. (627 aa)
	Gab2	Growth factor receptor bound protein 2-associated protein 2. (665 aa)
	Adamts17	A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17. (1122 aa)
	Cers3	Ceramide synthase 3. (419 aa)
	Sphk2	Sphingosine kinase 2. (617 aa)
	Bax	BCL2-associated X protein. (192 aa)
	Akt2	Thymoma viral proto-oncogene 2. (481 aa)
	Prkcg	Protein kinase C, gamma. (697 aa)
	Kras	Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (454 aa)
	Bid	BH3 interacting domain death agonist. (195 aa)
	Raf1	V-raf-leukemia viral oncogene 1. (648 aa)
	4930544G11Rik	RIKEN cDNA 4930544G11 gene. (193 aa)
	Rac1	Rac family small GTPase 1. (192 aa)
	Gna12	Guanine nucleotide binding protein, alpha 12. (379 aa)
	Mapk10	Mitogen-activated protein kinase 10. (494 aa)
	Ppp2r2c	Protein phosphatase 2, regulatory subunit B, gamma. (447 aa)
	Nos3	Nitric oxide synthase 3, endothelial cell. (1202 aa)
	Gnai1	Guanine nucleotide binding protein (G protein), alpha inhibiting 1. (354 aa)
	Prkcz	Protein kinase C, zeta. (592 aa)
	Pik3cd	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta. (1047 aa)
	Oprd1	Opioid receptor, delta 1. (372 aa)
	MGP_SPRETEiJ_P0066259	annotation not available (461 aa)
	Acer2	Alkaline ceramidase 2. (275 aa)
	Nsmaf	Neutral sphingomyelinase (N-SMase) activation associated factor. (920 aa)
	Nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105. (971 aa)
	Sgms2	Sphingomyelin synthase 2. (365 aa)
	Gnai3	Guanine nucleotide binding protein (G protein), alpha inhibiting 3. (354 aa)
	Tmigd3	Transmembrane and immunoglobulin domain containing 3. (210 aa)
	MGP_SPRETEiJ_P0062130	annotation not available (173 aa)
	Rhoc	Ras homolog family member C. (193 aa)
	Nras	Neuroblastoma ras oncogene. (189 aa)
	Csde1	Cold shock domain containing E1, RNA binding. (798 aa)
	Cers2	Ceramide synthase 2. (380 aa)
	Aadac	Arylacetamide deacetylase. (398 aa)
	Aadacl2	Arylacetamide deacetylase like 2. (401 aa)
	Aadacl2fm1	AADACL2 family member 1. (280 aa)
	MGP_SPRETEiJ_P0060097	annotation not available (377 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. (1068 aa)
	Pld1	Phospholipase D1. (894 aa)
	Srms	Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites. (507 aa)
	Ptk6	PTK6 protein tyrosine kinase 6. (451 aa)
	MGP_SPRETEiJ_P0057018	annotation not available (520 aa)
	Plcb4	Phospholipase C, beta 4. (1239 aa)
	Plcb1	Phospholipase C, beta 1. (1216 aa)
	Plcb2	Phospholipase C, beta 2. (1181 aa)
	Cers6	Ceramide synthase 6. (392 aa)
	Traf2	TNF receptor-associated factor 2. (508 aa)
	Pten	Phosphatase and tensin homolog. (403 aa)
	Sgms1	Sphingomyelin synthase 1. (419 aa)
	Asah2	N-acylsphingosine amidohydrolase 2. (756 aa)
	Gnaq	Guanine nucleotide binding protein, alpha q polypeptide. (359 aa)
	Ms4a2	Membrane-spanning 4-domains, subfamily A, member 2. (235 aa)
	Plcb3	Phospholipase C, beta 3. (1234 aa)
	Ppp2r5b	Protein phosphatase 2, regulatory subunit B', beta. (497 aa)
	Rela	V-rel reticuloendotheliosis viral oncogene homolog A (avian). (549 aa)
	Adamts19	A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19. (1210 aa)
	Ppp2r2b	Protein phosphatase 2, regulatory subunit B, beta. (446 aa)
	Rock1	Rho-associated coiled-coil containing protein kinase 1. (1354 aa)
	Prkce	Protein kinase C, epsilon. (737 aa)
	Acer1	Alkaline ceramidase 1. (273 aa)
	Ppp2r5d	Protein phosphatase 2, regulatory subunit B', delta. (594 aa)
	Tnf	Tumor necrosis factor. (235 aa)
	Mapk13	Mitogen-activated protein kinase 13. (366 aa)
	Mapk14	Mitogen-activated protein kinase 14. (360 aa)
	Pdpk1	3-phosphoinositide dependent protein kinase 1. (559 aa)
	Ppp2r1a	Protein phosphatase 2, regulatory subunit A, alpha. (589 aa)
	Mapk1	Mitogen-activated protein kinase 1. (358 aa)
	Abcc1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1. (1528 aa)
	MGP_SPRETEiJ_P0042319	annotation not available (107 aa)
	Cers5	Ceramide synthase 5. (414 aa)
	Mapk11	Mitogen-activated protein kinase 11. (364 aa)
	Mapk12	Mitogen-activated protein kinase 12. (367 aa)
	Rac2	Rac family small GTPase 2. (192 aa)
	Ppp2r2a	Protein phosphatase 2, regulatory subunit B, alpha. (447 aa)
	Mapk8	Mitogen-activated protein kinase 8. (427 aa)
	Pik3r1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	Sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (473 aa)
	S1pr3	Sphingosine-1-phosphate receptor 3. (378 aa)
	Akt1	Thymoma viral proto-oncogene 1. (480 aa)
	Ppp2r5c	Protein phosphatase 2, regulatory subunit B', gamma. (524 aa)
	Degs2	Delta(4)-desaturase, sphingolipid 2. (323 aa)
	Bdkrb2	Bradykinin receptor, beta 2. (392 aa)
	Sptlc2	Serine palmitoyltransferase, long chain base subunit 2. (560 aa)
	Sgpp1	Sphingosine-1-phosphate phosphatase 1. (430 aa)
	Ppp2r5e	Protein phosphatase 2, regulatory subunit B', epsilon. (467 aa)
	Rock2	Rho-associated coiled-coil containing protein kinase 2. (1388 aa)
	Rac3	Rac family small GTPase 3. (192 aa)
	Sphk1	Sphingosine kinase 1. (388 aa)
	Gna13	Guanine nucleotide binding protein, alpha 13. (377 aa)
	Prkca	Protein kinase C, alpha. (672 aa)
	Pld2	Phospholipase D2. (944 aa)
	Trp53	Transformation related protein 53. (390 aa)
	Ppp2ca	Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform. (307 aa)
	Mapk9	Mitogen-activated protein kinase 9. (423 aa)
	S1pr4	Sphingosine-1-phosphate receptor 4. (386 aa)
	Map2k2	Mitogen-activated protein kinase kinase 2. (401 aa)
	Sgpl1	Sphingosine phosphate lyase 1. (568 aa)
	Smpd2	Sphingomyelin phosphodiesterase 2, neutral. (419 aa)
	Fyn	Fyn proto-oncogene. (602 aa)
	Map3k5	Mitogen-activated protein kinase kinase kinase 5. (1380 aa)
	Ppp2r5a	Protein phosphatase 2, regulatory subunit B', alpha. (466 aa)
	Degs1	Delta(4)-desaturase, sphingolipid 1. (323 aa)
	9130409I23Rik	RIKEN cDNA 9130409I23 gene. (320 aa)
	Akt3	Thymoma viral proto-oncogene 3. (479 aa)
	Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide. (250 aa)
	MGP_SPRETEiJ_P0022205	annotation not available (92 aa)
	Adora1	Adenosine A1 receptor. (326 aa)
	Bcl2	B cell leukemia/lymphoma 2. (236 aa)
	Sgpp2	Sphingosine-1-phosphate phosphotase 2. (354 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
4930544G11Rik	Akt1	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0035012	RIKEN cDNA 4930544G11 gene.	Thymoma viral proto-oncogene 1.	0.470
4930544G11Rik	Bid	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0078982	RIKEN cDNA 4930544G11 gene.	BH3 interacting domain death agonist.	0.435
4930544G11Rik	Fyn	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0023801	RIKEN cDNA 4930544G11 gene.	Fyn proto-oncogene.	0.858
4930544G11Rik	Gna12	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0074710	RIKEN cDNA 4930544G11 gene.	Guanine nucleotide binding protein, alpha 12.	0.875
4930544G11Rik	Gna13	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0032134	RIKEN cDNA 4930544G11 gene.	Guanine nucleotide binding protein, alpha 13.	0.878
4930544G11Rik	Gnai1	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0069365	RIKEN cDNA 4930544G11 gene.	Guanine nucleotide binding protein (G protein), alpha inhibiting 1.	0.446
4930544G11Rik	Gnai2	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0093441	RIKEN cDNA 4930544G11 gene.	Guanine nucleotide binding protein (G protein), alpha inhibiting 2.	0.464
4930544G11Rik	Gnai3	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0062299	RIKEN cDNA 4930544G11 gene.	Guanine nucleotide binding protein (G protein), alpha inhibiting 3.	0.446
4930544G11Rik	Hras	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0086560	RIKEN cDNA 4930544G11 gene.	Harvey rat sarcoma virus oncogene.	0.507
4930544G11Rik	Kras	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0080085	RIKEN cDNA 4930544G11 gene.	Kirsten rat sarcoma viral oncogene homolog.	0.410
4930544G11Rik	MGP_SPRETEiJ_P0066259	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0066259	RIKEN cDNA 4930544G11 gene.	annotation not available	0.471
4930544G11Rik	Mapk10	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0072038	RIKEN cDNA 4930544G11 gene.	Mitogen-activated protein kinase 10.	0.878
4930544G11Rik	Mapk14	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0045584	RIKEN cDNA 4930544G11 gene.	Mitogen-activated protein kinase 14.	0.458
4930544G11Rik	Mapk3	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0085614	RIKEN cDNA 4930544G11 gene.	Mitogen-activated protein kinase 3.	0.460
4930544G11Rik	Mapk8	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0037905	RIKEN cDNA 4930544G11 gene.	Mitogen-activated protein kinase 8.	0.860
4930544G11Rik	Mapk9	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0027762	RIKEN cDNA 4930544G11 gene.	Mitogen-activated protein kinase 9.	0.862
4930544G11Rik	Nras	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0061978	RIKEN cDNA 4930544G11 gene.	Neuroblastoma ras oncogene.	0.411
4930544G11Rik	Pdpk1	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0044906	RIKEN cDNA 4930544G11 gene.	3-phosphoinositide dependent protein kinase 1.	0.585
4930544G11Rik	Pik3ca	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0059481	RIKEN cDNA 4930544G11 gene.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.	0.601
4930544G11Rik	Pik3cb	MGP_SPRETEiJ_P0077038	MGP_SPRETEiJ_P0092917	RIKEN cDNA 4930544G11 gene.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta.	0.562