(127 nodes) Serotonergic synapse network (Mus spretus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Alox15	Arachidonate 15-lipoxygenase. (663 aa)
	Alox12e	Arachidonate lipoxygenase, epidermal. (662 aa)
	Alox12	Arachidonate 12-lipoxygenase. (663 aa)
	Alox8	Arachidonate 8-lipoxygenase. (677 aa)
	Alox12b	Arachidonate 12-lipoxygenase, 12R type. (701 aa)
	Gabrb2	Gamma-aminobutyric acid (GABA) A receptor, subunit beta 2. (512 aa)
	Ddc	Dopa decarboxylase. (480 aa)
	Tph2	Tryptophan hydroxylase 2. (488 aa)
	Gng7	Guanine nucleotide binding protein (G protein), gamma 7. (69 aa)
	Kcnj9	Potassium inwardly-rectifying channel, subfamily J, member 9. (393 aa)
	Ptgs2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	Pla2g4a	Phospholipase A2, group IVA (cytosolic, calcium-dependent). (748 aa)
	Cacna1s	Calcium channel, voltage-dependent, L type, alpha 1S subunit. (1852 aa)
	Htr5b	5-hydroxytryptamine (serotonin) receptor 5B. (370 aa)
	Htr2b	5-hydroxytryptamine (serotonin) receptor 2B. (479 aa)
	Gng2	Guanine nucleotide binding protein (G protein), gamma 2. (71 aa)
	Cacna1d	Calcium channel, voltage-dependent, L type, alpha 1D subunit. (2166 aa)
	Htr1a	5-hydroxytryptamine (serotonin) receptor 1A. (421 aa)
	Gng4	Guanine nucleotide binding protein (G protein), gamma 4. (75 aa)
	Prkca	Protein kinase C, alpha. (672 aa)
	Gngt2	Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2. (69 aa)
	Slc6a4	Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4. (630 aa)
	Pelp1	Proline, glutamic acid and leucine rich protein 1. (1119 aa)
	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C. (459 aa)
	Araf	Araf proto-oncogene, serine/threonine kinase. (604 aa)
	Maob	Monoamine oxidase B. (520 aa)
	Maoa	Monoamine oxidase A. (526 aa)
	Eras	ES cell-expressed Ras. (227 aa)
	Cacna1f	Calcium channel, voltage-dependent, alpha 1F subunit. (1982 aa)
	Gnai2	Guanine nucleotide binding protein (G protein), alpha inhibiting 2. (355 aa)
	Trpc1	Transient receptor potential cation channel, subfamily C, member 1. (809 aa)
	Htr1b	5-hydroxytryptamine (serotonin) receptor 1B. (386 aa)
	Gnb5	Guanine nucleotide binding protein (G protein), beta 5. (395 aa)
	Map2k1	Mitogen-activated protein kinase kinase 1. (393 aa)
	Htr3b	5-hydroxytryptamine (serotonin) receptor 3B. (437 aa)
	Htr3a	5-hydroxytryptamine (serotonin) receptor 3A. (489 aa)
	Kcnj5	Potassium inwardly-rectifying channel, subfamily J, member 5. (419 aa)
	MGP_SPRETEiJ_P0089054	annotation not available (354 aa)
	Gm5741	Predicted gene 5741. (72 aa)
	Cacna1a	Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit. (2385 aa)
	Prkaca	Protein kinase, cAMP dependent, catalytic, alpha. (351 aa)
	Slc18a1	Solute carrier family 18 (vesicular monoamine), member 1. (521 aa)
	Hras	Harvey rat sarcoma virus oncogene. (189 aa)
	Mapk3	Mitogen-activated protein kinase 3. (380 aa)
	Prkcb	Protein kinase C, beta. (673 aa)
	Gabrb3	Gamma-aminobutyric acid (GABA) A receptor, subunit beta 3. (507 aa)
	Tph1	Tryptophan hydroxylase 1. (447 aa)
	Gng8	Guanine nucleotide binding protein (G protein), gamma 8. (70 aa)
	Pla2g4c	Phospholipase A2, group IVC (cytosolic, calcium-independent). (514 aa)
	Prkcg	Protein kinase C, gamma. (697 aa)
	Itpr2	Inositol 1,4,5-triphosphate receptor 2. (2701 aa)
	Kras	Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Gnb3	Guanine nucleotide binding protein (G protein), beta 3. (340 aa)
	Cacna1c	Calcium channel, voltage-dependent, L type, alpha 1C subunit. (2222 aa)
	Alox5	Arachidonate 5-lipoxygenase. (674 aa)
	Raf1	V-raf-leukemia viral oncogene 1. (648 aa)
	Itpr1	Inositol 1,4,5-trisphosphate receptor 1. (2749 aa)
	Gng12	Guanine nucleotide binding protein (G protein), gamma 12. (83 aa)
	Braf	Braf transforming gene. (804 aa)
	Kcnd2	Potassium voltage-gated channel, Shal-related family, member 2. (630 aa)
	Gng11	Guanine nucleotide binding protein (G protein), gamma 11. (73 aa)
	Gngt1	Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1. (74 aa)
	Cyp2w1	Cytochrome P450, family 2, subfamily w, polypeptide 1. (493 aa)
	Gnb2	Guanine nucleotide binding protein (G protein), beta 2. (382 aa)
	Gabrb1	Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1. (474 aa)
	Htr5a	5-hydroxytryptamine (serotonin) receptor 5A. (357 aa)
	Gnai1	Guanine nucleotide binding protein (G protein), alpha inhibiting 1. (354 aa)
	MGP_SPRETEiJ_P0068880	annotation not available (108 aa)
	Htr6	5-hydroxytryptamine (serotonin) receptor 6. (440 aa)
	Htr1d	5-hydroxytryptamine (serotonin) receptor 1D. (374 aa)
	Cyp4x1	Cytochrome P450, family 4, subfamily x, polypeptide 1. (507 aa)
	Cyp2j5	Cytochrome P450, family 2, subfamily j, polypeptide 5. (501 aa)
	Cyp2j9	Cytochrome P450, family 2, subfamily j, polypeptide 9. (502 aa)
	Cyp2j6	Cytochrome P450, family 2, subfamily j, polypeptide 6. (501 aa)
	Cyp2j8	Cytochrome P450, family 2, subfamily j, polypeptide 8. (503 aa)
	Cyp2j11	Cytochrome P450, family 2, subfamily j, polypeptide 11. (504 aa)
	Cyp2j7	Cytochrome P450, family 2, subfamily j, polypeptide 7. (504 aa)
	Cyp2j12	Cytochrome P450, family 2, subfamily j, polypeptide 12. (502 aa)
	Cyp2j13	Cytochrome P450, family 2, subfamily j, polypeptide 13. (503 aa)
	Gng10	Guanine nucleotide binding protein (G protein), gamma 10. (68 aa)
	Prkacb	Protein kinase, cAMP dependent, catalytic, beta. (398 aa)
	MGP_SPRETEiJ_P0063388	annotation not available (68 aa)
	Gnai3	Guanine nucleotide binding protein (G protein), alpha inhibiting 3. (354 aa)
	Nras	Neuroblastoma ras oncogene. (189 aa)
	Csde1	Cold shock domain containing E1, RNA binding. (798 aa)
	Gnb4	Guanine nucleotide binding protein (G protein), beta 4. (340 aa)
	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus. (1133 aa)
	Plcb4	Phospholipase C, beta 4. (1239 aa)
	Plcb1	Phospholipase C, beta 1. (1216 aa)
	Pla2g4f	Phospholipase A2, group IVF. (855 aa)
	Pla2g4d	Phospholipase A2, group IVD. (825 aa)
	Pla2g4e	Phospholipase A2, group IVE. (874 aa)
	MGP_SPRETEiJ_P0056027	annotation not available (791 aa)
	MGP_SPRETEiJ_P0056018	annotation not available (316 aa)
	Plcb2	Phospholipase C, beta 2. (1181 aa)
	Kcnj3	Potassium inwardly-rectifying channel, subfamily J, member 3. (501 aa)
	Ptgs1	Prostaglandin-endoperoxide synthase 1. (602 aa)
	Cacna1b	Calcium channel, voltage-dependent, N type, alpha 1B subunit. (2330 aa)
	Slc18a2	Solute carrier family 18 (vesicular monoamine), member 2. (517 aa)
	Cyp2c23	Cytochrome P450, family 2, subfamily c, polypeptide 23. (494 aa)
	Cyp2c70	Cytochrome P450, family 2, subfamily c, polypeptide 70. (489 aa)
	Cyp2c50	Cytochrome P450, family 2, subfamily c, polypeptide 50. (494 aa)
	MGP_SPRETEiJ_P0050719	annotation not available (178 aa)
	Cyp2c39	Cytochrome P450, family 2, subfamily c, polypeptide 39. (490 aa)
	Cyp2c38	Cytochrome P450, family 2, subfamily c, polypeptide 38. (490 aa)
	Cyp2c29	Cytochrome P450, family 2, subfamily c, polypeptide 29. (490 aa)
	Cyp2c65	Cytochrome P450, family 2, subfamily c, polypeptide 65. (490 aa)
	Cyp2c55	Cytochrome P450, family 2, subfamily c, polypeptide 55. (490 aa)
	Htr7	5-hydroxytryptamine (serotonin) receptor 7. (470 aa)
	Gnaq	Guanine nucleotide binding protein, alpha q polypeptide. (359 aa)
	Gng3	Guanine nucleotide binding protein (G protein), gamma 3. (75 aa)
	Plcb3	Phospholipase C, beta 3. (1234 aa)
	Htr4	5 hydroxytryptamine (serotonin) receptor 4. (388 aa)
	MGP_SPRETEiJ_P0048598	annotation not available (839 aa)
	Itpr3	Inositol 1,4,5-triphosphate receptor 3. (2670 aa)
	Dusp1	Dual specificity phosphatase 1. (367 aa)
	Gng13	Guanine nucleotide binding protein (G protein), gamma 13. (67 aa)
	Kcnj6	Potassium inwardly-rectifying channel, subfamily J, member 6. (425 aa)
	App	Amyloid beta (A4) precursor protein. (695 aa)
	Htr1f	5-hydroxytryptamine (serotonin) receptor 1F. (366 aa)
	Adcy5	Adenylate cyclase 5. (1265 aa)
	MGP_SPRETEiJ_P0042755	annotation not available (498 aa)
	Mapk1	Mitogen-activated protein kinase 1. (358 aa)
	Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3. (926 aa)
	MGP_SPRETEiJ_P0041014	annotation not available (150 aa)
	Cyp2d26	Cytochrome P450, family 2, subfamily d, polypeptide 26. (493 aa)
	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A. (471 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcy5	Cacna1c	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0078843	Adenylate cyclase 5.	Calcium channel, voltage-dependent, L type, alpha 1C subunit.	0.661
Adcy5	Gnai1	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0069365	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), alpha inhibiting 1.	0.962
Adcy5	Gnai2	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0093441	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), alpha inhibiting 2.	0.955
Adcy5	Gnai3	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0062299	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), alpha inhibiting 3.	0.909
Adcy5	Gnas	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0058692	Adenylate cyclase 5.	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus.	0.988
Adcy5	Gnb2	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0074327	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), beta 2.	0.831
Adcy5	Gnb3	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0079245	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), beta 3.	0.831
Adcy5	Gnb4	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0059504	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), beta 4.	0.726
Adcy5	Gnb5	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0092355	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), beta 5.	0.726
Adcy5	Gng10	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0064998	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 10.	0.832
Adcy5	Gng11	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0075286	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 11.	0.850
Adcy5	Gng12	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0077051	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 12.	0.675
Adcy5	Gng2	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0037386	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 2.	0.684
Adcy5	Gng3	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0050016	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 3.	0.850
Adcy5	Gng4	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0035252	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 4.	0.847
Adcy5	Gng7	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0025201	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma 7.	0.842
Adcy5	Gngt1	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0075284	Adenylate cyclase 5.	Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1.	0.827
Adcy5	MGP_SPRETEiJ_P0063388	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0063388	Adenylate cyclase 5.	annotation not available	0.835
Adcy5	MGP_SPRETEiJ_P0068880	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0068880	Adenylate cyclase 5.	annotation not available	0.835
Adcy5	MGP_SPRETEiJ_P0089054	MGP_SPRETEiJ_P0043297	MGP_SPRETEiJ_P0089054	Adenylate cyclase 5.	annotation not available	0.963