(89 nodes) Insulin secretion network (Mus spretus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ffar1	Free fatty acid receptor 1. (300 aa)
	Trpm4	Transient receptor potential cation channel, subfamily M, member 4. (1213 aa)
	Kcnj11	Potassium inwardly rectifying channel, subfamily J, member 11. (390 aa)
	Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8. (1588 aa)
	Prkcb	Protein kinase C, beta. (673 aa)
	Ins2	Insulin II. (110 aa)
	Kcnu1	Potassium channel, subfamily U, member 1. (1120 aa)
	Rab3a	RAB3A, member RAS oncogene family. (220 aa)
	Kcnn1	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1. (553 aa)
	Prkaca	Protein kinase, cAMP dependent, catalytic, alpha. (351 aa)
	Adcy7	Adenylate cyclase 7. (1104 aa)
	Atp1b3	ATPase, Na+/K+ transporting, beta 3 polypeptide. (278 aa)
	Cck	Cholecystokinin. (115 aa)
	Cacna1f	Calcium channel, voltage-dependent, alpha 1F subunit. (1982 aa)
	Atp1b4	ATPase, (Na+)/K+ transporting, beta 4 polypeptide. (356 aa)
	Gpr119	G-protein coupled receptor 119. (335 aa)
	Creb1	cAMP responsive element binding protein 1. (341 aa)
	Cacna1s	Calcium channel, voltage-dependent, L type, alpha 1S subunit. (1852 aa)
	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide. (304 aa)
	Atp1a4	ATPase, Na+/K+ transporting, alpha 4 polypeptide. (1032 aa)
	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide. (1020 aa)
	Gna11	Guanine nucleotide binding protein, alpha 11. (359 aa)
	Kcnmb4	Potassium large conductance calcium-activated channel, subfamily M, beta member 4. (210 aa)
	Gck	Glucokinase. (465 aa)
	Camk2b	Calcium/calmodulin-dependent protein kinase II, beta. (666 aa)
	Adcy1	Adenylate cyclase 1. (1118 aa)
	Kcnmb1	Potassium large conductance calcium-activated channel, subfamily M, beta member 1. (191 aa)
	MGP_SPRETEiJ_P0028857	annotation not available (163 aa)
	Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide. (290 aa)
	Gip	Gastric inhibitory polypeptide. (144 aa)
	Prkca	Protein kinase C, alpha. (672 aa)
	Adcy3	Adenylate cyclase 3. (1145 aa)
	Ptrhd1	peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	Chrm3	Cholinergic receptor, muscarinic 3, cardiac. (589 aa)
	Ryr2	Ryanodine receptor 2, cardiac. (4969 aa)
	Adcy2	Adenylate cyclase 2. (1095 aa)
	Rab3c	RAB3C, member RAS oncogene family. (227 aa)
	Camk2g	Calcium/calmodulin-dependent protein kinase II gamma. (529 aa)
	Kcnma1	Potassium large conductance calcium-activated channel, subfamily M, alpha member 1. (1239 aa)
	Cacna1d	Calcium channel, voltage-dependent, L type, alpha 1D subunit. (2166 aa)
	Rims2	Regulating synaptic membrane exocytosis 2. (1572 aa)
	Adcy8	Adenylate cyclase 8. (1249 aa)
	Atf4	Activating transcription factor 4. (349 aa)
	Adcy6	Adenylate cyclase 6. (1168 aa)
	Adcy9	Adenylate cyclase 9. (1353 aa)
	Adcy5	Adenylate cyclase 5. (1265 aa)
	Itpr3	Inositol 1,4,5-triphosphate receptor 3. (2670 aa)
	Glp1r	Glucagon-like peptide 1 receptor. (463 aa)
	Atf6b	Activating transcription factor 6 beta. (709 aa)
	Adcyap1	Adenylate cyclase activating polypeptide 1. (175 aa)
	MGP_SPRETEiJ_P0048598	annotation not available (839 aa)
	Arsi	Arylsulfatase i. (573 aa)
	Camk2a	Calcium/calmodulin-dependent protein kinase II alpha. (489 aa)
	Plcb3	Phospholipase C, beta 3. (1234 aa)
	Gnaq	Guanine nucleotide binding protein, alpha q polypeptide. (359 aa)
	Ins1	Insulin I. (108 aa)
	Gcg	Glucagon. (180 aa)
	Fap	Fibroblast activation protein. (761 aa)
	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4. (1011 aa)
	Atf2	Activating transcription factor 2. (487 aa)
	Creb3l1	cAMP responsive element binding protein 3-like 1. (520 aa)
	Plcb2	Phospholipase C, beta 2. (1181 aa)
	Plcb1	Phospholipase C, beta 1. (1216 aa)
	Plcb4	Phospholipase C, beta 4. (1239 aa)
	Snap25	Synaptosomal-associated protein 25. (206 aa)
	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus. (1133 aa)
	Tnik	TRAF2 and NCK interacting kinase. (1360 aa)
	Slc2a2	Solute carrier family 2 (facilitated glucose transporter), member 2. (523 aa)
	Kcnmb2	Potassium large conductance calcium-activated channel, subfamily M, beta member 2. (235 aa)
	Kcnmb3	Potassium large conductance calcium-activated channel, subfamily M, beta member 3. (239 aa)
	Kcnn3	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3. (746 aa)
	Creb3l4	cAMP responsive element binding protein 3-like 4. (370 aa)
	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide. (1023 aa)
	Camk2d	Calcium/calmodulin-dependent protein kinase II, delta. (533 aa)
	Prkacb	Protein kinase, cAMP dependent, catalytic, beta. (398 aa)
	Creb3	cAMP responsive element binding protein 3. (379 aa)
	Rab3b	RAB3B, member RAS oncogene family. (228 aa)
	Slc2a1	Solute carrier family 2 (facilitated glucose transporter), member 1. (492 aa)
	Pclo	Piccolo (presynaptic cytomatrix protein). (5298 aa)
	Cckar	Cholecystokinin A receptor. (436 aa)
	Stx1a	Syntaxin 1A (brain). (288 aa)
	Pdx1	Pancreatic and duodenal homeobox 1. (284 aa)
	Creb3l2	cAMP responsive element binding protein 3-like 2. (521 aa)
	Creb5	cAMP responsive element binding protein 5. (519 aa)
	Adcyap1r1	Adenylate cyclase activating polypeptide 1 receptor 1. (524 aa)
	Cacna1c	Calcium channel, voltage-dependent, L type, alpha 1C subunit. (2222 aa)
	Prkcg	Protein kinase C, gamma. (697 aa)
	Kcnn4	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. (425 aa)
	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide. (1054 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abcc8	Gcg	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0054035	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Glucagon.	0.573
Abcc8	Gck	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0026897	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Glucokinase.	0.623
Abcc8	Glp1r	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0045713	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Glucagon-like peptide 1 receptor.	0.606
Abcc8	Ins1	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0051128	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Insulin I.	0.613
Abcc8	Ins2	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0086837	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Insulin II.	0.617
Abcc8	Kcnj11	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0083003	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Potassium inwardly rectifying channel, subfamily J, member 11.	0.999
Abcc8	MGP_SPRETEiJ_P0028857	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0028857	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	annotation not available	0.439
Abcc8	Pdx1	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0075046	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Pancreatic and duodenal homeobox 1.	0.416
Abcc8	Prkaca	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0088698	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Protein kinase, cAMP dependent, catalytic, alpha.	0.926
Abcc8	Prkacb	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0063416	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Protein kinase, cAMP dependent, catalytic, beta.	0.952
Abcc8	Rapgef4	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0054352	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Rap guanine nucleotide exchange factor (GEF) 4.	0.990
Abcc8	Slc2a2	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0059377	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Solute carrier family 2 (facilitated glucose transporter), member 2.	0.641
Abcc8	Stx1a	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0074004	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Syntaxin 1A (brain).	0.735
Abcc8	Trpm4	MGP_SPRETEiJ_P0083004	MGP_SPRETEiJ_P0082815	ATP-binding cassette, sub-family C (CFTR/MRP), member 8.	Transient receptor potential cation channel, subfamily M, member 4.	0.849
Adcy1	Adcy2	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0036491	Adenylate cyclase 1.	Adenylate cyclase 2.	0.568
Adcy1	Adcy5	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0043297	Adenylate cyclase 1.	Adenylate cyclase 5.	0.562
Adcy1	Adcy6	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0041527	Adenylate cyclase 1.	Adenylate cyclase 6.	0.562
Adcy1	Adcy7	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0088964	Adenylate cyclase 1.	Adenylate cyclase 7.	0.589
Adcy1	Adcy9	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0042010	Adenylate cyclase 1.	Adenylate cyclase 9.	0.700
Adcy1	Camk2a	MGP_SPRETEiJ_P0026987	MGP_SPRETEiJ_P0048790	Adenylate cyclase 1.	Calcium/calmodulin-dependent protein kinase II alpha.	0.840