(108 nodes) Glucagon signaling pathway network (Mus spretus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Creb3l2	cAMP responsive element binding protein 3-like 2. (521 aa)
	Creb5	cAMP responsive element binding protein 5. (519 aa)
	Itpr1	Inositol 1,4,5-trisphosphate receptor 1. (2749 aa)
	Gys2	Glycogen synthase 2. (704 aa)
	Ldhb	Lactate dehydrogenase B. (334 aa)
	Itpr2	Inositol 1,4,5-triphosphate receptor 2. (2701 aa)
	Calm3	Calmodulin 3. (149 aa)
	Akt2	Thymoma viral proto-oncogene 2. (481 aa)
	Cpt1c	Carnitine palmitoyltransferase 1c. (798 aa)
	MGP_SPRETEiJ_P0082746	annotation not available (371 aa)
	MGP_SPRETEiJ_P0082747	annotation not available (353 aa)
	Gys1	Glycogen synthase 1, muscle. (738 aa)
	Ldha	Lactate dehydrogenase A. (361 aa)
	Ldhc	Lactate dehydrogenase C. (332 aa)
	Pde3b	Phosphodiesterase 3B, cGMP-inhibited. (1096 aa)
	Ppp4c	Protein phosphatase 4, catalytic subunit. (307 aa)
	Phkg2	Phosphorylase kinase, gamma 2 (testis). (406 aa)
	Prkaca	Protein kinase, cAMP dependent, catalytic, alpha. (351 aa)
	Phkb	Phosphorylase kinase beta. (1085 aa)
	Sik2	Salt inducible kinase 2. (929 aa)
	Parp6	Poly (ADP-ribose) polymerase family, member 6. (630 aa)
	Calml4	Calmodulin-like 4. (153 aa)
	4932429P05Rik	RIKEN cDNA 4932429P05 gene. (785 aa)
	4930415L06Rik	RIKEN cDNA 4930415L06 gene. (815 aa)
	Phka1	Phosphorylase kinase alpha 1. (1241 aa)
	Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
	Creb1	cAMP responsive element binding protein 1. (341 aa)
	Prkag3	Protein kinase, AMP-activated, gamma 3 non-catalytic subunit. (489 aa)
	Akt3	Thymoma viral proto-oncogene 3. (479 aa)
	Sirt1	Sirtuin 1. (737 aa)
	Pfkl	Phosphofructokinase, liver, B-type. (780 aa)
	Pgam2	Phosphoglycerate mutase 2. (253 aa)
	Gck	Glucokinase. (465 aa)
	Camk2b	Calcium/calmodulin-dependent protein kinase II, beta. (666 aa)
	Ppp3r1	Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I). (170 aa)
	Ppp4r3b	Protein phosphatase 4 regulatory subunit 3B. (820 aa)
	Acaca	acetyl-Coenzyme A carboxylase alpha. (2345 aa)
	G6pc	Glucose-6-phosphatase, catalytic. (357 aa)
	G6pc3	Glucose 6 phosphatase, catalytic, 3. (346 aa)
	Gcgr	Glucagon receptor. (485 aa)
	Pygl	Liver glycogen phosphorylase. (850 aa)
	Calm1	Calmodulin 1. (197 aa)
	Ppp4r3a	Protein phosphatase 4 regulatory subunit 3A. (833 aa)
	Akt1	Thymoma viral proto-oncogene 1. (480 aa)
	Calml3	Calmodulin-like 3. (149 aa)
	MGP_SPRETEiJ_P0035125	annotation not available (148 aa)
	MGP_SPRETEiJ_P0035127	annotation not available (134 aa)
	Pfkp	Phosphofructokinase, platelet. (784 aa)
	Fbp2	Fructose bisphosphatase 2. (339 aa)
	Fbp1	Fructose bisphosphatase 1. (338 aa)
	Adcy2	Adenylate cyclase 2. (1095 aa)
	MGP_SPRETEiJ_P0037217	annotation not available (705 aa)
	Pdhb	Pyruvate dehydrogenase (lipoamide) beta. (376 aa)
	Ppp3cb	Protein phosphatase 3, catalytic subunit, beta isoform. (525 aa)
	Camk2g	Calcium/calmodulin-dependent protein kinase II gamma. (529 aa)
	Pck2	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (667 aa)
	Ppp3cc	Protein phosphatase 3, catalytic subunit, gamma isoform. (513 aa)
	MGP_SPRETEiJ_P0039506	annotation not available (297 aa)
	Atf4	Activating transcription factor 4. (349 aa)
	Ep300	E1A binding protein p300. (2415 aa)
	Ppara	Peroxisome proliferator activated receptor alpha. (468 aa)
	Cpt1b	Carnitine palmitoyltransferase 1b, muscle. (772 aa)
	Pfkm	Phosphofructokinase, muscle. (854 aa)
	Prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (330 aa)
	Crebbp	CREB binding protein. (2442 aa)
	Ldhal6b	Lactate dehydrogenase A-like 6B. (382 aa)
	Itpr3	Inositol 1,4,5-triphosphate receptor 3. (2670 aa)
	Sik1	Salt inducible kinase 1. (779 aa)
	Calm2	Calmodulin 2. (149 aa)
	Arsi	Arylsulfatase i. (573 aa)
	Camk2a	Calcium/calmodulin-dependent protein kinase II alpha. (489 aa)
	Cpt1a	Carnitine palmitoyltransferase 1a, liver. (773 aa)
	Pygm	Muscle glycogen phosphorylase. (842 aa)
	Plcb3	Phospholipase C, beta 3. (1234 aa)
	Gnaq	Guanine nucleotide binding protein, alpha q polypeptide. (359 aa)
	Pgam1	Phosphoglycerate mutase 1. (254 aa)
	Gcg	Glucagon. (180 aa)
	Phkg1	Phosphorylase kinase gamma 1. (388 aa)
	Fap	Fibroblast activation protein. (761 aa)
	Pdha1	Pyruvate dehydrogenase E1 alpha 1. (390 aa)
	Phka2	Phosphorylase kinase alpha 2. (1240 aa)
	G6pc2	Glucose-6-phosphatase, catalytic, 2. (355 aa)
	Atf2	Activating transcription factor 2. (487 aa)
	Creb3l1	cAMP responsive element binding protein 3-like 1. (520 aa)
	Plcb2	Phospholipase C, beta 2. (1181 aa)
	Plcb1	Phospholipase C, beta 1. (1216 aa)
	Plcb4	Phospholipase C, beta 4. (1239 aa)
	Pygb	Brain glycogen phosphorylase. (843 aa)
	Pck1	Phosphoenolpyruvate carboxykinase 1, cytosolic. (622 aa)
	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus. (1133 aa)
	Tnik	TRAF2 and NCK interacting kinase. (1360 aa)
	Slc2a2	Solute carrier family 2 (facilitated glucose transporter), member 2. (523 aa)
	Foxo1	Forkhead box O1. (652 aa)
	Creb3l4	cAMP responsive element binding protein 3-like 4. (370 aa)
	Crtc2	CREB regulated transcription coactivator 2. (692 aa)
	Prkab2	Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (271 aa)
	Camk2d	Calcium/calmodulin-dependent protein kinase II, delta. (533 aa)
	Ppp3ca	Protein phosphatase 3, catalytic subunit, alpha isoform. (521 aa)
	Pdha2	Pyruvate dehydrogenase E1 alpha 2. (391 aa)
	Prkacb	Protein kinase, cAMP dependent, catalytic, beta. (398 aa)
	Creb3	cAMP responsive element binding protein 3. (379 aa)
	Ppp3r2	Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II). (179 aa)
	Prkaa2	Protein kinase, AMP-activated, alpha 2 catalytic subunit. (552 aa)
	Slc2a1	Solute carrier family 2 (facilitated glucose transporter), member 1. (492 aa)
	Prkag2	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit. (566 aa)
	Ppargc1a	Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha. (796 aa)
	Acacb	acetyl-Coenzyme A carboxylase beta. (2448 aa)
	Prkab1	Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)

Your Current Organism:

Mus spretus

NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
4930415L06Rik	Ppp3ca	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0063106	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 3, catalytic subunit, alpha isoform.	0.703
4930415L06Rik	Ppp3cb	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0037413	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 3, catalytic subunit, beta isoform.	0.698
4930415L06Rik	Ppp3cc	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0039020	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 3, catalytic subunit, gamma isoform.	0.640
4930415L06Rik	Ppp4c	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0085640	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 4, catalytic subunit.	0.974
4930415L06Rik	Ppp4r3a	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0034648	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 4 regulatory subunit 3A.	0.900
4930415L06Rik	Ppp4r3b	MGP_SPRETEiJ_P0095857	MGP_SPRETEiJ_P0027299	RIKEN cDNA 4930415L06 gene.	Protein phosphatase 4 regulatory subunit 3B.	0.735
4932429P05Rik	Ppp3ca	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0063106	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 3, catalytic subunit, alpha isoform.	0.703
4932429P05Rik	Ppp3cb	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0037413	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 3, catalytic subunit, beta isoform.	0.698
4932429P05Rik	Ppp3cc	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0039020	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 3, catalytic subunit, gamma isoform.	0.640
4932429P05Rik	Ppp4c	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0085640	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 4, catalytic subunit.	0.974
4932429P05Rik	Ppp4r3a	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0034648	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 4 regulatory subunit 3A.	0.900
4932429P05Rik	Ppp4r3b	MGP_SPRETEiJ_P0095856	MGP_SPRETEiJ_P0027299	RIKEN cDNA 4932429P05 gene.	Protein phosphatase 4 regulatory subunit 3B.	0.735
Acaca	Acacb	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0072651	acetyl-Coenzyme A carboxylase alpha.	acetyl-Coenzyme A carboxylase beta.	0.884
Acaca	Akt1	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0035012	acetyl-Coenzyme A carboxylase alpha.	Thymoma viral proto-oncogene 1.	0.523
Acaca	Cpt1a	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0049289	acetyl-Coenzyme A carboxylase alpha.	Carnitine palmitoyltransferase 1a, liver.	0.804
Acaca	Cpt1b	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0041295	acetyl-Coenzyme A carboxylase alpha.	Carnitine palmitoyltransferase 1b, muscle.	0.712
Acaca	Cpt1c	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0082745	acetyl-Coenzyme A carboxylase alpha.	Carnitine palmitoyltransferase 1c.	0.748
Acaca	G6pc	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0031479	acetyl-Coenzyme A carboxylase alpha.	Glucose-6-phosphatase, catalytic.	0.520
Acaca	Gck	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0026897	acetyl-Coenzyme A carboxylase alpha.	Glucokinase.	0.406
Acaca	Ldha	MGP_SPRETEiJ_P0030288	MGP_SPRETEiJ_P0083068	acetyl-Coenzyme A carboxylase alpha.	Lactate dehydrogenase A.	0.615