STRINGSTRING
Ccl26 Ccl26 Cxcl9 Cxcl9 Cxcl10 Cxcl10 Cxcr3 Cxcr3 Ccr3 Ccr3 Ccl11 Ccl11 Ccr4 Ccr4 Ccl5 Ccl5 Ccl3 Ccl3 Ccl4 Ccl4 Cxcr5 Cxcr5 Ccr6 Ccr6 Ccl20 Ccl20 Ccl17 Ccl17 Ccl22 Ccl22 Ccr10 Ccr10 Pf4 Pf4 Cxcl13 Cxcl13 Cxcl11 Cxcl11 Ccl24 Ccl24 Ccl27 Ccl27 Ccr5 Ccr5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ccl26C-C motif chemokine ligand 26. (94 aa)
Cxcl9C-X-C motif chemokine. (125 aa)
Cxcl10C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] (98 aa)
Cxcr3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
Ccr3C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (360 aa)
Ccl11Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. (97 aa)
Ccr4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
Ccl5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (92 aa)
Ccl3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. (92 aa)
Ccl4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (92 aa)
Cxcr5C-X-C chemokine receptor type 5; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes (By similarity). (374 aa)
Ccr6Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. (366 aa)
Ccl20C-C motif chemokine 20; Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand- receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, ne [...] (96 aa)
Ccl17C-C motif chemokine. (93 aa)
Ccl22C-C motif chemokine. (92 aa)
Ccr10G protein-coupled receptor 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. (362 aa)
Pf4Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation; Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
Cxcl13Similar to Small inducible cytokine B13 (CXCL13) (B lymphocyte chemoattractant) (CXC chemokine BLC). (109 aa)
Cxcl11C-X-C motif chemokine. (100 aa)
Ccl24Chemokine (C-C motif) ligand 24. (119 aa)
Ccl27Chemokine (C-C motif) ligand 27 (Predicted), isoform CRA_b. (164 aa)
Ccr5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (354 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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