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| | Cd160 | CD160 molecule. (184 aa) |
| | Ly86 | Lymphocyte antigen 86 (Predicted). (187 aa) |
| | Prf1 | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family. (526 aa) |
| | Ncr3 | Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. (195 aa) |
| | Cd40lg | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa) |
| | Fcer2 | Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a. (331 aa) |
| | Cd80 | CD80 antigen, isoform CRA_a. (321 aa) |
| | Cd86 | Cd86 antigen, isoform CRA_c. (313 aa) |
| | Tnfsf4 | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family. (199 aa) |
| | Cd247 | CD3 antigen, zeta polypeptide, isoform CRA_b. (164 aa) |
| | Cd244 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. (394 aa) |
| | Cd48 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. (240 aa) |
| | Sh2d1a | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (126 aa) |
| | Cd8b | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (208 aa) |
| | Cd8a | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (236 aa) |
| | Tnfsf15 | Tumor necrosis factor ligand superfamily member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity). (270 aa) |
| | Lck | Proto-oncogene tyrosine-protein kinase LCK; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associa [...] (520 aa) |
| | Cd28 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (218 aa) |
| | Cd180 | CD180 antigen (Predicted), isoform CRA_a. (662 aa) |
| | Gzma | Granzyme A; Belongs to the peptidase S1 family. (261 aa) |
| | Gzmk | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily. (258 aa) |
| | Blk | Tyrosine-protein kinase. (499 aa) |
| | Cd79b | B29/Ig-beta/CD79b. (228 aa) |
| | Lgals5 | Galectin-5; May function in erythrocyte differentiation. (145 aa) |
| | Lgals9 | Galectin-9; Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma mem [...] (354 aa) |
| | Tnfrsf14 | Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (278 aa) |
| | Cd52 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. (96 aa) |
| | Cd2 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. (344 aa) |
| | Cd3g | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (182 aa) |
| | Cd3d | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (173 aa) |
| | Pdcd1lg2 | Programmed cell death 1 ligand 2. (268 aa) |
| | Cd4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (457 aa) |
| | Nkg7 | Natural killer cell group 7 sequence, isoform CRA_a. (165 aa) |
| | Cd53 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); Belongs to the tetraspanin (TM4SF) family. (219 aa) |
| | Ncr1 | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. (325 aa) |
| | Pdcd1-2 | Programmed cell death 1 (Predicted). (287 aa) |
| | Tnfrsf4 | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). (271 aa) |
| | Cd79a | Ig-like domain-containing protein. (235 aa) |
| | Cd81 | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (236 aa) |
| | Hcst | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] (79 aa) |
| | Ms4a1 | Membrane spanning 4-domains A1. (298 aa) |
| | Cd27 | Similar to CD27 antigen-mouse, isoform CRA_b. (251 aa) |
| | Cd274 | Similar to PD-1-ligand (Predicted). (290 aa) |
| | Mzb1 | Marginal zone B- and B1-cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation. (188 aa) |
| | Icoslg | Inducible T-cell co-stimulator ligand. (307 aa) |
| | Cd22 | CD22 antigen (Predicted). (852 aa) |
| | Igll1 | Immunoglobulin lambda-like polypeptide 1. (209 aa) |
| | Cd96 | T-cell surface protein tactile; May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity). (603 aa) |
| | Tnfsf18 | TNF superfamily member 18. (173 aa) |
| | Slamf6 | SLAM family member 6. (343 aa) |
| | Ctsw | Cathepsin W; Belongs to the peptidase C1 family. (371 aa) |
| | Tnfrsf18 | Similar to tumor necrosis factor receptor superfamily, member 18, isoform CRA_b. (274 aa) |
| | Ly9 | Lymphocyte antigen 9. (655 aa) |
| | Fcmr | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity). (447 aa) |
| | Lag3 | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] (525 aa) |
| | Slamf7 | Similar to SLAM family member 7 (Predicted), isoform CRA_a. (342 aa) |
| | Ptprcap | Protein tyrosine phosphatase receptor type C-associated protein. (197 aa) |
| | Fcrl1 | Fc receptor-like 1. (343 aa) |
| | Cd84 | CD84 molecule. (334 aa) |
| | Sh2d1b | SH2 domain-containing 1B. (132 aa) |
| | Cd3e | CD3 antigen, epsilon polypeptide (Predicted). (188 aa) |
| | Havcr2 | Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] (282 aa) |
| | Cd276 | CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells (By similarity). (316 aa) |
| | Btla | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. (308 aa) |
| | Cd19 | CD19 molecule. (547 aa) |
| | Cd40 | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. (289 aa) |
| | Tnfrsf25 | Similar to tumor necrosis factor receptor superfamily, member 25, isoform CRA_a. (407 aa) |
| | Tnfrsf9 | Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a. (258 aa) |
| | Cd226 | CD226 antigen (Predicted), isoform CRA_b. (346 aa) |
| | Sh2d1b2 | SH2 domain-containing 1B2. (132 aa) |
| | Trat1 | T cell receptor-associated transmembrane adaptor 1. (186 aa) |
| | Rrlt | Retinoic acid early transcript 1E. (394 aa) |
| | Cd37 | Leukocyte antigen CD37. (304 aa) |
| | Pvr | PVR cell adhesion molecule. (412 aa) |
| | Pou2af1 | POU class 2 homeobox-associating factor 1. (256 aa) |
| | Ptprc | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (1273 aa) |
| | Tnfsf8 | Tumor necrosis factor ligand 3a; Belongs to the tumor necrosis factor family. (237 aa) |
| | Icos | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] (200 aa) |
| | M0R5C7_RAT | Ig-like domain-containing protein. (118 aa) |
| | Cd70 | Cd70 molecule; Belongs to the tumor necrosis factor family. (195 aa) |
| | Cd79al | Cd79a molecule-like. (123 aa) |
| | Tnfsf9 | Tumor necrosis factor (Ligand) superfamily, member 9; Belongs to the tumor necrosis factor family. (308 aa) |
| | Pdcd1 | Programmed cell death 1. (287 aa) |
| | Tnfsf14 | Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen). (239 aa) |
| | LOC103694871 | pre-B lymphocyte protein 3-like. (106 aa) |
| | Cd5 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. (503 aa) |
| | Klrk1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (229 aa) |
| | Slamf1 | Similar to signaling lymphocytic activation molecule (Predicted). (345 aa) |
| | Ctla4 | Cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a. (223 aa) |
| | Ulbp1 | UL16-binding protein 1. (255 aa) |
| | M0RE12_RAT | Tyrosine-protein kinase. (295 aa) |
| | Cr2 | Complement C3d receptor 2. (1406 aa) |
| | Micb | MHC class I polypeptide-related sequence B. (372 aa) |
| | Tnfrsf8 | Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity). Regulates gene expression through activation of NF-kappa-B. (492 aa) |
| | Fcrla | Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis. (350 aa) |
| | Tigit | T cell immunoreceptor with Ig and ITIM domains. (242 aa) |
