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| | Olig2 | Oligodendrocyte transcription factor 2. (323 aa) |
| | Atoh7 | Atonal bHLH transcription factor 7. (149 aa) |
| | Neurog3 | Neurogenin 3. (214 aa) |
| | Gsx1 | Genomic screened homeo box 1 (Predicted). (261 aa) |
| | Lhx5 | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. (402 aa) |
| | Dlx2 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. (332 aa) |
| | Dlx1 | Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin- A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesi [...] (255 aa) |
| | Hes1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (281 aa) |
| | Barhl2 | BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up- regulate NGN2, thereby regulating distinct patterns of neuronal differentiation; Belongs to the BAR homeobox family. (384 aa) |
| | Nkx6-1 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). (365 aa) |
| | Gsx2 | Genomic screened homeo box 2 protein. (305 aa) |
| | Myt1l | Myelin transcription factor 1-like protein; Transcription factor that plays a key role in neuronal differentiation. Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 [...] (1182 aa) |
| | Lmx1a | LIM homeobox transcription factor 1 alpha. (382 aa) |
| | Bcl11b | BAF chromatin-remodeling complex subunit BCL11B. (921 aa) |
| | Neurod1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] (357 aa) |
| | Sp8 | Sp8 transcription factor. (504 aa) |
| | Lhx6 | LIM homeobox 6. (392 aa) |
| | Six6 | Sine oculis-related homeobox 6 homolog (Drosophila) (Predicted). (246 aa) |
| | Pou3f2 | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] (445 aa) |
| | Mafa | Transcription factor MafA; Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity); Belongs to the bZIP family. (361 aa) |
| | Pax4 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity); Belongs to the paired homeobox family. (349 aa) |
| | Fezf2 | Zinc finger protein 312 (Predicted). (455 aa) |
| | Emx2 | Similar to empty spiracles-like protein 2 (Predicted), isoform CRA_a. (253 aa) |
| | Foxp1 | Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neur [...] (711 aa) |
| | Neurog2 | Neurogenin 2. (263 aa) |
| | Irx5 | Iroquois homeobox protein 5. (484 aa) |
| | Irx3 | Iroquois related homeobox 3 (Drosophila) (Predicted), isoform CRA_b. (326 aa) |
| | Vsx2 | Ceh-10 homeo domain containing homolog (C. elegans), isoform CRA_a. (361 aa) |
| | Neurod6 | Neurogenic differentiation factor. (337 aa) |
| | Pou4f2 | POU domain, class 4, transcription factor 2; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooper [...] (412 aa) |
| | Irx2 | Iroquois homeobox 2. (474 aa) |
| | Isl1 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequence [...] (349 aa) |
| | Nkx2-2 | NK2 homeobox 2. (273 aa) |
| | Satb1 | DNA-binding protein SATB. (764 aa) |
| | Barhl1 | BarH-like 1 homeobox protein. (327 aa) |
| | Foxa2 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] (459 aa) |
| | Rbpms | RNA-binding protein, mRNA-processing factor. (220 aa) |
| | Zic1 | Zinc finger protein of the cerebellum 1, isoform CRA_a. (447 aa) |
| | Zic4 | Zic family member 4. (326 aa) |
| | Nr2f1 | Nuclear receptor subfamily 2, group F, member 1. (420 aa) |
| | Emx1 | Similar to empty spiracles homolog 1 (Predicted). (290 aa) |
| | Mafb | Transcription factor MafB; Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to s [...] (323 aa) |
| | Ptf1a | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] (326 aa) |
| | Calb2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa) |
| | Pitx3 | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] (302 aa) |
| | Gbx2 | Gastrulation brain homeobox 2. (348 aa) |
| | Zbtb45 | Zinc finger protein 499 (Predicted), isoform CRA_a. (519 aa) |
| | Sp9 | Sp9 transcription factor. (485 aa) |
| | Sall3 | Sal-like 3 (Drosophila) (Predicted). (1190 aa) |
| | Onecut1 | Hepatocyte nuclear factor 6; Transcriptional activator. Binds the consensus sequence 5'- DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. The affinity of HNF- 6-alpha and HNF-6-beta for DNA differs depending on the target sequence. (465 aa) |
| | Sox11 | Transcription factor SOX-11; Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development. (395 aa) |
| | Irx1 | Iroquois homeobox 1. (480 aa) |
| | Nr4a2 | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver- specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR. (598 aa) |
| | Lhx3 | RCG45383, isoform CRA_b. (402 aa) |
| | Hnf1b | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. (557 aa) |
| | Tshz1 | Teashirt zinc finger family member 1. (1070 aa) |
| | Cux1 | Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Binds to the TH enhancer; may require the basic helix-loop-helix protein T [...] (1504 aa) |
| | Vsx1 | Visual system homeobox 1. (369 aa) |
| | Dmrta2 | DMRT-like family A2. (532 aa) |
| | Tbr1 | T-box brain transcription factor 1. (680 aa) |
| | Foxn4 | Forkhead box N4 (Predicted). (476 aa) |
| | Corin | Atrial natriuretic peptide-converting enzyme, activated protease fragment; Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB [...] (1111 aa) |
| | Zic5 | Zinc finger protein of the cerebellum 5 (Predicted). (265 aa) |
| | Otx2 | Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'; Belongs to the paired homeobox family. Bicoid subfamily. (289 aa) |
| | Mnx1 | Motor neuron and pancreas homeobox 1. (402 aa) |
| | Pdx1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa) |
| | Cnpy1 | DUF3456 domain-containing protein. (172 aa) |
| | Dlx6 | Similar to Homeobox protein DLX-6 (Predicted). (175 aa) |
| | En1 | Homeobox protein engrailed-like. (399 aa) |
| | Foxp2 | Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels. (710 aa) |
| | Opn4 | Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal. (474 aa) |
| | Zic2 | Zic family member 2. (529 aa) |
| | Foxp4 | Forkhead box P4. (671 aa) |
| | Pax6 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains; Belongs to the paired homeobox family. (433 aa) |
| | Satb2 | DNA-binding protein SATB. (733 aa) |
| | Sncg | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). (123 aa) |
| | Otx1 | Homeobox protein OTX1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC- 3' (By similarity). May play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex, and also in cerebellar regionalization during early development. Belongs to the paired homeobox family. Bicoid subfamily. (324 aa) |
| | Six3 | SIX homeobox 3. (336 aa) |
| | LOC100911492 | Orthodenticle homeobox 2. (289 aa) |
| | Nfia | Nuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family. (508 aa) |
| | Pou3f3 | POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). (487 aa) |
| | Pou4f1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N- terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects ne [...] (417 aa) |
