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Gsx1 Gsx1 Dlx2 Dlx2 Dlx1 Dlx1 Gsx2 Gsx2 Bcl11b Bcl11b Sp8 Sp8 Lhx6 Lhx6 Fezf2 Fezf2 Emx2 Emx2 Foxp1 Foxp1 Neurod6 Neurod6 Satb1 Satb1 Nr2f1 Nr2f1 Emx1 Emx1 Calb2 Calb2 Sp9 Sp9 Tshz1 Tshz1 Cux1 Cux1 Dmrta2 Dmrta2 Tbr1 Tbr1 Dlx6 Dlx6 Foxp2 Foxp2 Foxp4 Foxp4 Satb2 Satb2 Nfia Nfia
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gsx1Genomic screened homeo box 1 (Predicted). (261 aa)
Dlx2Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. (332 aa)
Dlx1Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin- A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesi [...] (255 aa)
Gsx2Genomic screened homeo box 2 protein. (305 aa)
Bcl11bBAF chromatin-remodeling complex subunit BCL11B. (921 aa)
Sp8Sp8 transcription factor. (504 aa)
Lhx6LIM homeobox 6. (392 aa)
Fezf2Zinc finger protein 312 (Predicted). (455 aa)
Emx2Similar to empty spiracles-like protein 2 (Predicted), isoform CRA_a. (253 aa)
Foxp1Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neur [...] (711 aa)
Neurod6Neurogenic differentiation factor. (337 aa)
Satb1DNA-binding protein SATB. (764 aa)
Nr2f1Nuclear receptor subfamily 2, group F, member 1. (420 aa)
Emx1Similar to empty spiracles homolog 1 (Predicted). (290 aa)
Calb2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa)
Sp9Sp9 transcription factor. (485 aa)
Tshz1Teashirt zinc finger family member 1. (1070 aa)
Cux1Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Binds to the TH enhancer; may require the basic helix-loop-helix protein T [...] (1504 aa)
Dmrta2DMRT-like family A2. (532 aa)
Tbr1T-box brain transcription factor 1. (680 aa)
Dlx6Similar to Homeobox protein DLX-6 (Predicted). (175 aa)
Foxp2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels. (710 aa)
Foxp4Forkhead box P4. (671 aa)
Satb2DNA-binding protein SATB. (733 aa)
NfiaNuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family. (508 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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