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Nsun5 Nsun5 N6amt1 N6amt1 Gtpbp8 Gtpbp8 Osgepl1 Osgepl1 Ftsj1 Ftsj1 Thg1l Thg1l Trnt1 Trnt1 Gtpbp10 Gtpbp10 Qtrt1 Qtrt1 Trmt12 Trmt12 Malsu1 Malsu1 Tyw5 Tyw5 Pus7 Pus7 LOC100911166 LOC100911166 Trmt9b Trmt9b Rpusd1 Rpusd1 Rpusd4 Rpusd4 Nsun4 Nsun4 LOC103690007 LOC103690007 Pus3 Pus3 Trit1 Trit1 Cdk5rap1 Cdk5rap1 Trub1 Trub1 Nsun2 Nsun2 Mtg1 Mtg1 Ddx28 Ddx28 Wdr6 Wdr6 Trmt112 Trmt112 Trmt6 Trmt6 Thada Thada Pus7l Pus7l Mrm1 Mrm1 Yrdc Yrdc Tyw3 Tyw3 Nsun7 Nsun7 Tyw1 Tyw1 Trdmt1 Trdmt1 F1M3Y3_RAT F1M3Y3_RAT Trmt2a Trmt2a Mrm2 Mrm2 Mrm3 Mrm3 Mterf4 Mterf4 Pus1 Pus1 Mto1 Mto1 Gtpbp3 Gtpbp3 Wdr4 Wdr4 Rpusd3 Rpusd3 Lcmt2 Lcmt2 Trmu Trmu Trub2 Trub2 Mettl1 Mettl1 Rpusd2 Rpusd2 Trmt5 Trmt5 Trmt11 Trmt11 Pus10 Pus10 Trmt61a Trmt61a Trmt10a Trmt10a Qtrt2 Qtrt2 Nsun3 Nsun3 Mtg2 Mtg2 Noa1 Noa1 Pusl1 Pusl1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Nsun5NOL1/NOP2/Sun domain family, member 5 (Predicted); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (451 aa)
N6amt1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
Gtpbp8GTP-binding protein 8. (285 aa)
Osgepl1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
Ftsj1Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (324 aa)
Thg1lProbable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. (298 aa)
Trnt1tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (434 aa)
Gtpbp10Claudin 12 (Predicted). (369 aa)
Qtrt1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (419 aa)
Trmt12tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). (437 aa)
Malsu1Similar to chromosome 7 open reading frame 30 (Predicted). (229 aa)
Tyw5tRNA-yW synthesizing protein 5. (315 aa)
Pus7Pseudouridine synthase 7. (660 aa)
LOC100911166RNA pseudouridylate synthase domain containing 2 (Predicted). (553 aa)
Trmt9bSimilar to 6430573F11Rik protein (Predicted), isoform CRA_d. (446 aa)
Rpusd1RNA pseudouridylate synthase domain containing 1 (Predicted), isoform CRA_a. (306 aa)
Rpusd4Mitochondrial RNA pseudouridine synthase Rpusd4; Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt- rRNA, controls 16S mt-rRNA abundance and is required for intra- mitochondrial translation. (377 aa)
Nsun4NOL1/NOP2/Sun domain family, member 4 (Predicted); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (381 aa)
LOC103690007NOP2/Sun RNA methyltransferase 4. (381 aa)
Pus3Pseudouridylate synthase 3 (Predicted). (479 aa)
Trit1tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (479 aa)
Cdk5rap1CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. (586 aa)
Trub1Probable tRNA pseudouridine synthase 1; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. (341 aa)
Nsun2NOL1/NOP2/Sun domain family, member 2 (Predicted); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (782 aa)
Mtg1Mitochondrial GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (326 aa)
Ddx28DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 (Predicted). (540 aa)
Wdr6WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy; Belongs to the WD repeat WDR6 family. (1125 aa)
Trmt112Similar to RIKEN cDNA 0610038D11 (Predicted), isoform CRA_b. (125 aa)
Trmt6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (495 aa)
ThadaTHADA, armadillo repeat-containing. (1937 aa)
Pus7lPseudouridine synthase 7-like. (709 aa)
Mrm1Mitochondrial rRNA methyltransferase 1. (320 aa)
YrdcYrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters. (280 aa)
Tyw3tRNA-yW synthesizing protein 3 homolog. (293 aa)
Nsun7NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (702 aa)
Tyw1Radical S-adenosyl methionine and flavodoxin domains 1 (Predicted), isoform CRA_a. (724 aa)
Trdmt1tRNA (cytosine(38)-C(5))-methyltransferase; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). (391 aa)
F1M3Y3_RATMethyltransf_25 domain-containing protein. (219 aa)
Trmt2aTRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (615 aa)
Mrm2Mitochondrial rRNA methyltransferase 2. (246 aa)
Mrm3Similar to putative RNA methyltransferase (Predicted). (418 aa)
Mterf4Transcription termination factor 4, mitochondrial; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (By similarity); Belongs to the mTERF family. (347 aa)
Pus1tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA; Belongs to the tRNA pseudouridine synthase TruA family. (423 aa)
Mto1Mitochondrial tRNA translation optimization 1. (661 aa)
Gtpbp3tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (492 aa)
Wdr4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (455 aa)
Rpusd3RNA pseudouridylate synthase domain containing 3 (Predicted), isoform CRA_c. (320 aa)
Lcmt2tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. (686 aa)
TrmuMitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family. (441 aa)
Trub2Mitochondrial mRNA pseudouridine synthase Trub2; Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. (323 aa)
Mettl1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (267 aa)
Rpusd2RNA pseudouridine synthase domain containing 2. (553 aa)
Trmt5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (496 aa)
Trmt11tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. (463 aa)
Pus10Similar to RIKEN cDNA 4933435A13, isoform CRA_a. (528 aa)
Trmt61atRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)- methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. (290 aa)
Trmt10atRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. (340 aa)
Qtrt2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (415 aa)
Nsun3NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (307 aa)
Mtg2Mitochondrial ribosome-associated GTPase 2. (496 aa)
Noa1MMR_HSR1 domain containing protein RGD1359460, isoform CRA_a. (694 aa)
Pusl1tRNA pseudouridine synthase. (291 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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