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| | Cd82 | CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. (266 aa) |
| | RGD1310429 | Similar to Protein Njmu-R1. (393 aa) |
| | Chmp2b | Charged multivesicular body protein 2B. (213 aa) |
| | Vps37b | Vacuolar protein sorting 37B (Yeast) (Predicted), isoform CRA_b. (285 aa) |
| | F1M053_RAT | EF-hand domain-containing protein; Belongs to the S-100 family. (116 aa) |
| | RGD1566265 | Similar to RIKEN cDNA 2610002M06 (Predicted). (199 aa) |
| | Cacybp | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). (229 aa) |
| | Vps4b | Vacuolar protein sorting 4 homolog B (S. cerevisiae); Belongs to the AAA ATPase family. (444 aa) |
| | Upk1b | Uroplakin-1b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity); Belongs to the tetraspanin (TM4SF) family. (287 aa) |
| | Lgals3bp | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). (574 aa) |
| | Tspan6 | Tetraspanin. (245 aa) |
| | Chmp6 | Chromatin modifying protein 6 (Predicted). (200 aa) |
| | Tspan8 | Tetraspanin. (235 aa) |
| | Tspan13 | Tetraspanin-13. (204 aa) |
| | Crip1 | Cysteine-rich protein 1; Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (77 aa) |
| | Prss27 | Serine protease 27. (328 aa) |
| | Snf8 | Vacuolar-sorting protein SNF8; Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in tr [...] (258 aa) |
| | Igsf8 | Immunoglobulin superfamily, member 8, isoform CRA_b. (611 aa) |
| | Chmp3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (223 aa) |
| | Tspan18 | Tetraspanin. (248 aa) |
| | Fam91a1 | Family with sequence similarity 91, member A1. (838 aa) |
| | Chmp5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | Pdcd6ip | Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires [...] (868 aa) |
| | Sdcbp2 | Syntenin-2; Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival. (296 aa) |
| | S100a11 | Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes. (98 aa) |
| | Lgals1 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. (135 aa) |
| | Sdcbp | Syntenin-1; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell- surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP [...] (300 aa) |
| | Chmp4c | Charged multivesicular body protein 4c; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (232 aa) |
| | Gpm6a | Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances intern [...] (278 aa) |
| | Anxa6 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. (673 aa) |
| | Tspan14 | Tetraspanin. (270 aa) |
| | Anxa11 | Annexin. (503 aa) |
| | S100a6 | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. (89 aa) |
| | Upk2 | Uroplakin 2. (184 aa) |
| | Vps37a | Similar to DNA segment, Chr 8, ERATO Doi 531, expressed, isoform CRA_c. (398 aa) |
| | S100a16 | S100 calcium binding protein A16 (Predicted), isoform CRA_a; Belongs to the S-100 family. (123 aa) |
| | Vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may a [...] (386 aa) |
| | S100a1 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer (By similarity). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (By similarity). Belongs to the S-100 family. (94 aa) |
| | Tsg101 | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the [...] (391 aa) |
| | Upk3a | Uroplakin 3A (Predicted). (287 aa) |
| | Capg | Macrophage-capping protein; Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+) (By similarity); Belongs to the villin/gelsolin family. (349 aa) |
| | Vps28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the endosomal sorting complex required for transport-I (ESCRT-I) complex, a regulator of vesicular trafficking process. The ESCRT-I complex participates in the sorting of membrane proteins into vesicles that bud into late endosomal compartments called multivesicular bodies, and is also involved in the budding of many viruses. (221 aa) |
| | Ifitm2 | Interferon-induced transmembrane protein 2. (144 aa) |
| | Siah1 | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin- mediated degradation of many substrates, including proteins involved in transcription [...] (282 aa) |
| | Epcam | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. (315 aa) |
| | Ptgfrn | Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). (879 aa) |
| | Chmp1a | Charged multivesicular body protein 1A. (196 aa) |
| | Tspan3 | Tetraspanin. (253 aa) |
| | Mvb12b | Multivesicular body subunit 12B. (317 aa) |
| | Chmp7 | CHMP family, member 7 (Predicted), isoform CRA_a. (450 aa) |
| | Mvb12a | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family. (271 aa) |
| | Anxa4 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. (319 aa) |
| | Cd9 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (226 aa) |
| | Tm9sf1 | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (589 aa) |
| | Mdp1 | Similar to magnesium-dependent phosphatase-1 (Predicted), isoform CRA_b. (164 aa) |
| | Wdr11 | WD repeat domain 11. (1224 aa) |
| | Fxyd5 | FXYD domain-containing ion transport regulator 5; Belongs to the FXYD family. (178 aa) |
| | Emp3 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions; Belongs to the PMP-22/EMP/MP20 family. (163 aa) |
| | Anxa9 | Annexin. (344 aa) |
| | F1M0J8_RAT | Uncharacterized protein. (97 aa) |
| | Stam2 | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] (523 aa) |
| | Upk3b | Uroplakin 3B. (275 aa) |
| | Upk1a | Cytochrome c oxidase, subunit VIb (Predicted); Belongs to the tetraspanin (TM4SF) family. (207 aa) |
| | Ahnak2 | Uncharacterized protein. (5582 aa) |
| | Tspan31 | Tetraspanin-31. (210 aa) |
| | S100a10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (95 aa) |
| | Chmp2a | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. (222 aa) |
| | Anxa2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (339 aa) |
| | F1LYQ0_RAT | Protein S100; Belongs to the S-100 family. (103 aa) |
| | Tspan4 | Tetraspanin. (238 aa) |
| | Vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. (176 aa) |
| | Chmp4bl1 | Chromatin-modifying protein 4B-like 1. (224 aa) |
| | Vps4a | Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] (510 aa) |
| | Uevld | UEV and lactate/malate dehyrogenase domains. (470 aa) |
| | Hgs | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (914 aa) |
| | Ptpn23 | Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity). (1666 aa) |
| | Tspan7 | Tetraspanin. (244 aa) |
| | Anxa7 | Annexin. (463 aa) |
| | Clic1 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (241 aa) |
| | Tiam2 | TIAM Rac1-associated GEF 2. (1714 aa) |
| | Anxa13 | Annexin. (319 aa) |
| | Ubap1 | Ubiquitin-associated protein 1; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. (502 aa) |
| | Anxa3 | Annexin A3; Inhibitor of phospholipase A2, also possesses anti-coagulant properties; Belongs to the annexin family. (324 aa) |
| | Tspan10 | Tetraspanin. (331 aa) |
| | Tspan15 | Tetraspanin. (293 aa) |
| | LOC100365259 | SPT2 chromatin protein domain-containing 1. (675 aa) |
| | Ubap1l | Ubiquitin-associated protein 1-like. (380 aa) |
| | M0RAB0_RAT | Tetraspanin. (249 aa) |
| | Sri | LOC683667 protein. (198 aa) |
| | Vps37d | VPS37D subunit of ESCRT-I. (261 aa) |
| | Chmp4b | Uncharacterized protein. (222 aa) |
| | Vta1 | Similar to RIKEN cDNA 1110059P08. (309 aa) |
| | Lgals7 | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). (136 aa) |
| | Ahnak | AHNAK nucleoprotein. (5450 aa) |
| | Cldn7 | Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. (211 aa) |
| | Stambp | STAM-binding protein; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM- CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not [...] (424 aa) |
| | D3ZYC5_RAT | Ubiquitin-like domain-containing protein. (115 aa) |
| | Lgals3 | Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes (By simil [...] (265 aa) |
| | Vps37c | Vacuolar protein sorting 37C (Yeast) (Predicted). (353 aa) |
| | Tspan17 | Tetraspanin-17; Regulates ADAM10 maturation. (281 aa) |
| | Cd63 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (262 aa) |
| | Brox | BRO1 domain-containing protein BROX; Belongs to the BROX family. (411 aa) |
| | Tspan11 | Tetraspanin-11. (253 aa) |
| | Vps37c-2 | VPS37C subunit of ESCRT-I. (353 aa) |
| | Stam | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (547 aa) |
| | Olr174 | Olfactory receptor. (318 aa) |
| | Tspan9 | Tetraspanin. (330 aa) |
