node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Inpp5f | LOC103689941 | ENSRNOP00000027630 | ENSRNOP00000010885 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | 0.906 |
Inpp5f | Mtm1 | ENSRNOP00000027630 | ENSRNOP00000058761 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] | 0.911 |
Inpp5f | Mtmr14 | ENSRNOP00000027630 | ENSRNOP00000010723 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Similar to FLJ22405 protein (Predicted). | 0.905 |
Inpp5f | Ocrl | ENSRNOP00000027630 | ENSRNOP00000072408 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] | 0.916 |
Inpp5f | Pi4k2a | ENSRNOP00000027630 | ENSRNOP00000019874 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4- phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...] | 0.912 |
Inpp5f | Pi4k2b | ENSRNOP00000027630 | ENSRNOP00000005349 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] | 0.905 |
Inpp5f | Pi4ka | ENSRNOP00000027630 | ENSRNOP00000072265 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. | 0.908 |
Inpp5f | Pi4kb | ENSRNOP00000027630 | ENSRNOP00000070653 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.902 |
Inpp5f | Pip5k1a | ENSRNOP00000027630 | ENSRNOP00000028609 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4- phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.902 |
Inpp5f | Pip5k1b | ENSRNOP00000027630 | ENSRNOP00000063506 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). | 0.902 |
Inpp5f | Pip5kl1 | ENSRNOP00000027630 | ENSRNOP00000067014 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | PIPK domain-containing protein. | 0.900 |
Inpp5f | Sacm1l | ENSRNOP00000027630 | ENSRNOP00000007223 | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2. | 0.901 |
LOC103689941 | Inpp5f | ENSRNOP00000010885 | ENSRNOP00000027630 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Inositol polyphosphate-5-phosphatase F (Predicted), isoform CRA_c. | 0.906 |
LOC103689941 | Ocrl | ENSRNOP00000010885 | ENSRNOP00000072408 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] | 0.941 |
LOC103689941 | Pi4k2a | ENSRNOP00000010885 | ENSRNOP00000019874 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4- phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...] | 0.679 |
LOC103689941 | Pi4k2b | ENSRNOP00000010885 | ENSRNOP00000005349 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] | 0.679 |
LOC103689941 | Pi4ka | ENSRNOP00000010885 | ENSRNOP00000072265 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. | 0.693 |
LOC103689941 | Pi4kb | ENSRNOP00000010885 | ENSRNOP00000070653 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.699 |
LOC103689941 | Pip5k1a | ENSRNOP00000010885 | ENSRNOP00000028609 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4- phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.910 |
LOC103689941 | Pip5k1b | ENSRNOP00000010885 | ENSRNOP00000063506 | Type II inositol 1,4,5-trisphosphate 5-phosphatase-like. | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). | 0.910 |