node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mical1 | Mical2 | ENSRNOP00000000337 | ENSRNOP00000074877 | [F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | 0.440 |
Mical1 | Nedd9 | ENSRNOP00000000337 | ENSRNOP00000071096 | [F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] | Neural precursor cell-expressed, developmentally down-regulated 9. | 0.860 |
Mical2 | Mical1 | ENSRNOP00000074877 | ENSRNOP00000000337 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | [F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] | 0.440 |
Mical2 | Micalcl | ENSRNOP00000074877 | ENSRNOP00000075121 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | MICAL C-terminal-like protein; May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking; Belongs to the ebitein family. | 0.937 |
Mical2 | Nedd9 | ENSRNOP00000074877 | ENSRNOP00000071096 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | Neural precursor cell-expressed, developmentally down-regulated 9. | 0.661 |
Mical3 | Nedd9 | ENSRNOP00000072316 | ENSRNOP00000071096 | Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. | Neural precursor cell-expressed, developmentally down-regulated 9. | 0.698 |
Mical3 | Ninl | ENSRNOP00000072316 | ENSRNOP00000061689 | Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. | Ninein-like. | 0.636 |
Micalcl | Mical2 | ENSRNOP00000075121 | ENSRNOP00000074877 | MICAL C-terminal-like protein; May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking; Belongs to the ebitein family. | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | 0.937 |
Nedd9 | Mical1 | ENSRNOP00000071096 | ENSRNOP00000000337 | Neural precursor cell-expressed, developmentally down-regulated 9. | [F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] | 0.860 |
Nedd9 | Mical2 | ENSRNOP00000071096 | ENSRNOP00000074877 | Neural precursor cell-expressed, developmentally down-regulated 9. | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] | 0.661 |
Nedd9 | Mical3 | ENSRNOP00000071096 | ENSRNOP00000072316 | Neural precursor cell-expressed, developmentally down-regulated 9. | Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. | 0.698 |
Ninl | Mical3 | ENSRNOP00000061689 | ENSRNOP00000072316 | Ninein-like. | Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. | 0.636 |