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Rpp21 Rpp21 Pop5 Pop5 Pop7 Pop7 Trmt10c Trmt10c Dgcr8 Dgcr8 Tsen54 Tsen54 Pop1 Pop1 Prorp Prorp Ago2 Ago2 Dicer1 Dicer1 Prkra Prkra Mov10 Mov10 Pop4 Pop4 Rpp25 Rpp25 Rpp30 Rpp30 Ago4 Ago4 Lin28b Lin28b Ddx5 Ddx5 Hsd17b10 Hsd17b10 Ago3 Ago3 Drosha Drosha Rpp38 Rpp38 Rpp14 Rpp14 Tarbp2 Tarbp2 LOC103690064 LOC103690064 Rpp40 Rpp40 Tsn Tsn Tsnax Tsnax Ddx17 Ddx17 Toe1 Toe1 Tnrc6a Tnrc6a Tsen34 Tsen34 Tsen15 Tsen15 Ago1 Ago1 Tsen34-2 Tsen34-2 Tsen2 Tsen2 Rpp25l Rpp25l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rpp21Ribonuclease P 21 subunit (Human), isoform CRA_c. (150 aa)
Pop5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (169 aa)
Pop7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
Trmt10ctRNA methyltransferase 10 homolog C; Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 a [...] (414 aa)
Dgcr8DiGeorge syndrome critical region gene 8 (Predicted), isoform CRA_a. (773 aa)
Tsen54tRNA-splicing endonuclease subunit 54. (525 aa)
Pop1Processing of 1, ribonuclease P/MRP family, (S. cerevisiae) (Predicted), isoform CRA_a. (1044 aa)
ProrpMitochondrial ribonuclease P catalytic subunit; Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. (587 aa)
Ago2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (880 aa)
Dicer1Dicer 1 ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1918 aa)
PrkraInterferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association, sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a [...] (313 aa)
Mov10Mov10 RISC complex RNA helicase. (1004 aa)
Pop4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (221 aa)
Rpp25Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (199 aa)
Rpp30Ribonuclease P/MRP subunit p30. (268 aa)
Ago4Eukaryotic translation initiation factor 2C, 4 (Predicted). (597 aa)
Lin28bLin-28 homolog B. (271 aa)
Ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5. (615 aa)
Hsd17b103-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20- beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structura [...] (261 aa)
Ago3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
DroshaDrosha ribonuclease III. (1373 aa)
Rpp38Ribonuclease P/MRP 38 subunit (Human). (272 aa)
Rpp14Ribonuclease P/MRP subunit p14. (122 aa)
Tarbp2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (365 aa)
LOC103690064M7GpppN-mRNA hydrolase-like. (356 aa)
Rpp40Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (363 aa)
TsnTranslin. (228 aa)
TsnaxTranslin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). (290 aa)
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a; Belongs to the DEAD box helicase family. (652 aa)
Toe1Target of EGR1, member 1 (Nuclear) (Predicted), isoform CRA_e. (504 aa)
Tnrc6aTrinucleotide repeat-containing adaptor 6A. (1954 aa)
Tsen34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (312 aa)
Tsen15Similar to RIKEN cDNA 5730449L18 (Predicted), isoform CRA_a. (168 aa)
Ago1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
Tsen34-2tRNA splicing endonuclease subunit 34. (312 aa)
Tsen2tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (463 aa)
Rpp25lRibonuclease P/MRP subunit p25-like. (163 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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