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| | Kpna6 | Importin subunit alpha; Functions in nuclear protein import. (541 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | Pom121 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Belongs to the POM121 family. (1199 aa) |
| | Nup153 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] (1468 aa) |
| | Ranbp1 | RAN-binding protein 1. (203 aa) |
| | Nup54 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. (510 aa) |
| | Nup85 | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Invo [...] (656 aa) |
| | Nxt1 | NTF2-related export protein 1 (Predicted), isoform CRA_a. (140 aa) |
| | Nup37 | Nucleoporin 37 (Predicted), isoform CRA_a. (326 aa) |
| | Rangrf | RAN guanine nucleotide release factor. (185 aa) |
| | Snupn | Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. (358 aa) |
| | Nup210 | Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. (1886 aa) |
| | Nup88 | Nuclear pore complex protein Nup88; Component of nuclear pore complex. (742 aa) |
| | Nup107 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. Belongs to the nucleoporin Nup84/Nup107 family. (925 aa) |
| | Xpot | Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (728 aa) |
| | Cse1l | Chromosome segregation 1-like (S. cerevisiae) (Predicted). (971 aa) |
| | Ipo9 | Importin 9 (Predicted). (1041 aa) |
| | Kpnb1 | Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic [...] (876 aa) |
| | Nup35 | Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity). (325 aa) |
| | Srsf4 | Serine and arginine-rich-splicing factor 4. (488 aa) |
| | Nupl2 | Similar to nucleoporin like 2 (Predicted), isoform CRA_a. (418 aa) |
| | Ipo7 | Importin 7 (Predicted), isoform CRA_c. (1038 aa) |
| | Xpo1 | Exportin-1; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from t [...] (1071 aa) |
| | Ndc1 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. (795 aa) |
| | Sec13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum; Belongs to the WD repeat SEC13 family. (322 aa) |
| | Kpna4 | Importin subunit alpha; Functions in nuclear protein import. (521 aa) |
| | Nup205 | Nucleoporin 205kDa (Predicted). (2008 aa) |
| | Ipo5 | Importin 5. (1097 aa) |
| | Nxf2 | Nuclear RNA export factor 2. (619 aa) |
| | Nup58 | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. (585 aa) |
| | Ddx25 | ATP-dependent RNA helicase DDX25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). (483 aa) |
| | Nup50 | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. (467 aa) |
| | Xpo7 | Exportin 7. (1090 aa) |
| | Aaas | Achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) (Predicted), isoform CRA_a. (546 aa) |
| | Gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (698 aa) |
| | Xpo6 | Exportin 6, isoform CRA_c. (1125 aa) |
| | Nup133 | Nucleoporin 133. (1154 aa) |
| | Ncoa5 | Nuclear receptor coactivator 5 (Predicted). (578 aa) |
| | Nup93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling. (819 aa) |
| | Nutf2 | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. (127 aa) |
| | Nxt2 | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity). (172 aa) |
| | Xpo5 | Exportin 5. (1204 aa) |
| | Nxf1 | Nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1- NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A- containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A- containing mRNA-binding to both [...] (618 aa) |
| | Ipo4 | Importin 4 (Predicted), isoform CRA_b. (1081 aa) |
| | Ipo13 | Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] (963 aa) |
| | Nup98 | Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. Belongs to the nucleoporin GLFG family. (1816 aa) |
| | Rae1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family. (368 aa) |
| | 1700123L14Rik | Npap60 protein. (436 aa) |
| | Nup188 | Nucleoporin 188. (1541 aa) |
| | Kpna3 | Importin subunit alpha; Functions in nuclear protein import. (521 aa) |
| | Nxf3 | Nuclear RNA export factor 3. (557 aa) |
| | Nup214 | Nucleoporin 214. (1790 aa) |
| | Nup160 | Nucleoporin 160. (1226 aa) |
| | Nxf7 | Nuclear RNA export factor 7. (614 aa) |
| | Rasl2-9 | GTP-binding nuclear protein Ran, testis-specific isoform; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). (216 aa) |
| | Tnpo3 | Transportin 3. (923 aa) |
| | RGD1306195 | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa) |
| | RGD1565693 | Uncharacterized protein. (698 aa) |
| | Adgrd1 | Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family. (903 aa) |
| | Tpr | Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA [...] (2360 aa) |
| | Nxf5 | NTF2 domain-containing protein. (441 aa) |
| | M0R627_RAT | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (197 aa) |
| | LOC100359600 | Karyopherin alpha 2-like. (529 aa) |
| | Ipo11 | Importin 11. (976 aa) |
| | Nup214-2 | Nucleoporin 214. (279 aa) |
| | Nup62 | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuc [...] (525 aa) |
| | Kpna7 | Importin subunit alpha; Functions in nuclear protein import. (500 aa) |
| | Pom121l2 | POM121 transmembrane nucleoporin-like 2. (519 aa) |
| | Nup43 | LOC683983 protein. (378 aa) |
| | Kpna1 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] (538 aa) |
| | Ahctf1 | AT hook-containing transcription factor 1. (2312 aa) |
| | A0A0G2K222_RAT | Uncharacterized protein. (453 aa) |
| | Rcc1 | Regulator of chromosome condensation 1. (421 aa) |
| | Nup155 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis (By similarity). Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. (1390 aa) |
| | Ranbp6 | RAN-binding protein 6. (1105 aa) |
| | Ranbp17 | RAN-binding protein 17. (1108 aa) |
| | Nup62cl | Similar to Nucleoporin 62 (Predicted). (273 aa) |
