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Fance Fance Gen1 Gen1 Ube2t Ube2t Fanca Fanca Fancc Fancc Slx1b Slx1b Mus81 Mus81 Eme1 Eme1 Eme2 Eme2 Slx4 Slx4 Faap24 Faap24 Fan1 Fan1 Dclre1a Dclre1a Fancl Fancl Fancf Fancf Fanci Fanci Faap100 Faap100 Faap20 Faap20 Fancg Fancg Dclre1b Dclre1b Fancb Fancb Fancd2 Fancd2 Fancm Fancm
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FanceFA complementation group E. (547 aa)
Gen1Similar to RIKEN cDNA 5830483C08 gene (Predicted), isoform CRA_a. (908 aa)
Ube2tUbiquitin-conjugating enzyme E2T (Putative) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
FancaFanconi anemia, complementation group A (Predicted). (1190 aa)
FanccFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). (557 aa)
Slx1bStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa)
Mus81Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (551 aa)
Eme1Essential meiotic structure-specific endonuclease 1. (569 aa)
Eme2Essential meiotic structure-specific endonuclease subunit 2. (375 aa)
Slx4SLX4 structure-specific endonuclease subunit. (1721 aa)
Faap24Similar to RIKEN cDNA C230052I12 (Predicted). (221 aa)
Fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1020 aa)
Dclre1aDNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) (Predicted). (1026 aa)
FanclFA complementation group L. (375 aa)
FancfFA complementation group F. (338 aa)
FanciFA complementation group I. (1333 aa)
Faap100FA core complex-associated protein 100. (882 aa)
Faap20Fanconi anemia core complex-associated protein 20; Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys- 63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity). (184 aa)
FancgFA complementation group G. (623 aa)
Dclre1b5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] (541 aa)
FancbFA complementation group B. (853 aa)
Fancd2Fanconi anemia group D2 protein homolog; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-ce [...] (1453 aa)
FancmFA complementation group M. (2017 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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