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| | Mad1l1 | Mitotic arrest deficient 1-like 1. (717 aa) |
| | Nuf2 | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. (464 aa) |
| | Cenpf | Centromere protein F. (2985 aa) |
| | Pttg1 | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (199 aa) |
| | Nek2 | NIMA (never in mitosis gene a)-related kinase 2-like 1. (443 aa) |
| | Kif18a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (811 aa) |
| | Mad2l1 | MAD2 (Mitotic arrest deficient, homolog)-like 1 (Yeast) (Predicted), isoform CRA_a. (205 aa) |
| | Dsn1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae). (348 aa) |
| | Spc25 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (226 aa) |
| | Mis12 | Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments. (206 aa) |
| | Bub1b | BUB1 mitotic checkpoint serine/threonine kinase B. (1055 aa) |
| | Tpx2 | TPX2, microtubule-associated protein homolog (Xenopus laevis) (Predicted), isoform CRA_a. (744 aa) |
| | Arhgap11a | Rho GTPase-activating protein 11A. (994 aa) |
| | Kif14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1672 aa) |
| | Ncapd3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1497 aa) |
| | Zwilch | Zwilch kinetochore protein. (597 aa) |
| | Knstrn | Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus- ends during live cell mitosis, possibly by forming a link between spindle microtubule [...] (312 aa) |
| | Depdc1 | DEP domain-containing 1. (809 aa) |
| | Cdkn3 | Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). (212 aa) |
| | Smc4 | Structural maintenance of chromosomes protein. (1286 aa) |
| | Dlgap5 | DLG-associated protein 5. (815 aa) |
| | Spag5 | Sperm-associated antigen 5. (1188 aa) |
| | Ncaph | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (732 aa) |
| | Aspm | Abnormal spindle microtubule assembly. (3133 aa) |
| | Espl1 | Extra spindle pole bodies-like 1, separase. (2109 aa) |
| | Prc1 | Protein regulator of cytokinesis 1 (Predicted), isoform CRA_b. (606 aa) |
| | Ect2 | Epithelial cell-transforming 2. (912 aa) |
| | Cdca3 | Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). (273 aa) |
| | Aurkc | Aurora kinase C; Belongs to the protein kinase superfamily. (308 aa) |
| | Pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (637 aa) |
| | Fam83d | Similar to Protein C20orf129 homolog (Predicted). (585 aa) |
| | Cep55 | Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney. (462 aa) |
| | Pclaf | PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity). (110 aa) |
| | Kif2c | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. (721 aa) |
| | Kif22 | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (657 aa) |
| | Bub3 | BUB3 mitotic checkpoint protein. (627 aa) |
| | Cenpe | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2439 aa) |
| | Ncapg2 | Non-SMC condensin II complex, subunit G2. (1137 aa) |
| | Kif23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (944 aa) |
| | Kif18b | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). (826 aa) |
| | Tacc3 | Transforming, acidic coiled-coil-containing protein 3. (587 aa) |
| | Ckap2l | Cytoskeleton-associated protein 2-like. (744 aa) |
| | Pmf1 | Polyamine-modulated factor 1. (202 aa) |
| | Cdc20 | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] (499 aa) |
| | Ckap2 | Cytoskeleton-associated protein 2. (676 aa) |
| | Cdca2 | Cell division cycle-associated 2. (981 aa) |
| | Bub1 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). (1059 aa) |
| | Cdca8 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). (288 aa) |
| | Spc24 | SPC24 component of NDC80 kinetochore complex. (197 aa) |
| | Kif20b | Kinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1773 aa) |
| | Aurka | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] (397 aa) |
| | Ncapg | Non-SMC condensin I complex, subunit G. (1002 aa) |
| | Melk | Maternal embryonic leucine zipper kinase (Predicted); Belongs to the protein kinase superfamily. (362 aa) |
| | Nsl1 | Similar to DC8/DC31 protein (Predicted), isoform CRA_b. (281 aa) |
| | Pbk | PDZ-binding kinase. (337 aa) |
| | Smc2 | Structural maintenance of chromosomes protein. (1191 aa) |
| | Kifc1 | Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. (693 aa) |
| | Kntc1 | Kinetochore associated 1 (Predicted). (2050 aa) |
| | Cdca5 | Cell division cycle-associated 5. (454 aa) |
| | Birc5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | Zwint | ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). (266 aa) |
| | Racgap1 | Rac GTPase-activating protein 1 (Predicted). (626 aa) |
| | Ncapd2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1389 aa) |
| | Nusap1 | Nucleolar and spindle-associated protein 1. (384 aa) |
| | Hmmr | Hyaluronan-mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity (By similarity). May act as a regulator of adipogenisis (By similarity). (712 aa) |
| | Kif15 | Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. (1385 aa) |
| | Incenp | Inner centromere protein. (899 aa) |
| | Troap | Trophinin-associated protein. (671 aa) |
| | Ndc80 | NDC80 kinetochore complex component. (642 aa) |
| | Ttk | Ttk protein kinase. (863 aa) |
| | Aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (343 aa) |
| | Kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa) |
| | Kif4a | Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1231 aa) |
| | Ncaph2 | Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at an [...] (632 aa) |
