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| | Oasl | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity). (512 aa) |
| | Oasl2 | 2'-5'-oligoadenylate synthase-like protein 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent p [...] (503 aa) |
| | Oas1b | Inactive 2'-5'-oligoadenylate synthase 1B; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (By similarity); Belongs to the 2-5A synthase family. (379 aa) |
| | Mx2 | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. (659 aa) |
| | Stap1 | Signal transducing adaptor family member 1. (297 aa) |
| | Ifi47 | Interferon gamma-inducible protein 47. (420 aa) |
| | LOC102556096 | Pyrin domain-containing protein. (134 aa) |
| | Ro60 | TROVE domain family, member 2 (Predicted). (538 aa) |
| | Tbk1 | Similar to TANK-binding kinase 1. (729 aa) |
| | Ly6e | Similar to lymphocyte antigen 6 complex, locus E, isoform CRA_a. (136 aa) |
| | Ifih1 | Interferon-induced with helicase C domain 1. (1027 aa) |
| | Rsad2 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa) |
| | Ifi27 | Interferon, alpha-inducible protein 27. (182 aa) |
| | Epsti1 | Epithelial-stromal interaction protein 1; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity). (314 aa) |
| | Kbtbd11 | Kelch repeat and BTB domain-containing 11. (633 aa) |
| | Ddx41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41. (622 aa) |
| | Ifitm3 | Interferon-induced transmembrane protein 3; May inhibit early replication of influenza A virus, dengue virus, and West Nile virus; Belongs to the CD225/Dispanin family. (137 aa) |
| | Gbp4 | Guanylate-binding protein 4. (620 aa) |
| | Irf7 | Interferon regulatory factor 7. (456 aa) |
| | Dhx58 | DEXH-box helicase 58. (678 aa) |
| | Trim21 | Tripartite motif protein 21 (Predicted), isoform CRA_a. (471 aa) |
| | Ifit1 | Interferon-induced protein with tetratricopeptide repeats 1. (462 aa) |
| | Ifi30 | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity); Belongs to the GILT family. (248 aa) |
| | Irf3 | Interferon regulatory factor 3, isoform CRA_c. (421 aa) |
| | Ifi35 | Interferon-induced protein 35, isoform CRA_a. (286 aa) |
| | Mnda | Myeloid cell nuclear differentiation antigen. (438 aa) |
| | LOC685067 | Guanylate binding protein 7. (626 aa) |
| | Ifit3 | Interferon-induced protein with tetratricopeptide repeats 3. (411 aa) |
| | Gbp5 | Guanylate-binding protein 5. (586 aa) |
| | Mavs | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that [...] (507 aa) |
| | Parp9 | Poly [ADP-ribose] polymerase. (830 aa) |
| | Igtp | Interferon gamma-induced GTPase. (1388 aa) |
| | Dtx3l | Deltex E3 ubiquitin ligase 3L. (750 aa) |
| | Isg15 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). (161 aa) |
| | Nmi | N-myc (and STAT) interactor. (215 aa) |
| | Oas1a | 2'-5'-oligoadenylate synthase 1A; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] (367 aa) |
| | F1LZJ7_RAT | Takusan domain-containing protein. (104 aa) |
| | Ifitm1 | Interferon-induced transmembrane protein 1. (109 aa) |
| | Mx1 | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). (652 aa) |
| | Gbp3 | Guanylate-binding protein 3. (633 aa) |
| | Lrrfip1 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Belongs to the LRRFIP family. (738 aa) |
| | Rtp4 | Receptor (chemosensory) transporter protein 4. (245 aa) |
| | Parp14 | Poly [ADP-ribose] polymerase. (1787 aa) |
| | Gbp1 | GB1/RHD3-type G domain-containing protein. (593 aa) |
| | Oas1g | 2 '-5 ' oligoadenylate synthetase 1I. (382 aa) |
| | Oas1i | 2'-5' oligoadenylate synthetase 1G. (382 aa) |
| | Rnf213 | Ring finger protein 213. (5136 aa) |
| | Ifit2 | Interferon-induced protein with tetratricopeptide repeats 2. (464 aa) |
| | Usp18 | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. (362 aa) |
| | D3ZLH9_RAT | Uncharacterized protein. (402 aa) |
| | Xaf1 | XIAP-associated factor 1. (273 aa) |
| | Plscr1 | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. (352 aa) |
| | Sp110 | Sp110 nuclear body protein; May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells (By similarity). (478 aa) |
| | LOC103689988 | 2'-5'-oligoadenylate synthase 1A-like. (362 aa) |
| | Herc6 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. (1027 aa) |
| | Olr1645 | Olfactory receptor. (334 aa) |
| | Ddx58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). (598 aa) |
| | Rin2 | Ras and Rab interactor 2 (Predicted), isoform CRA_c. (902 aa) |
| | Gbp2 | Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). (591 aa) |
| | Sting1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol [...] (379 aa) |
| | Ifi44l | Interferon-induced protein 44-like. (443 aa) |
| | Gbp6 | Guanylate-binding protein family member 6. (565 aa) |
| | A0A0G2JVT8_RAT | Uncharacterized protein. (1548 aa) |
| | Samd9 | Sterile alpha motif domain-containing 9. (1593 aa) |
| | Zbp1 | Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). (409 aa) |
| | Ifi44 | Interferon-induced protein 44, isoform CRA_a. (422 aa) |
| | Eif2ak2 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] (513 aa) |
| | Oas3 | 2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] (1005 aa) |
| | Oas2 | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivir [...] (732 aa) |
| | A0A0G2K7M9_RAT | Uncharacterized protein. (584 aa) |
| | Isg20 | Interferon-stimulated exonuclease gene 20. (185 aa) |
| | Cenpb | Centromere protein B. (603 aa) |
