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Asl Asl Prodh1 Prodh1 Pycr2 Pycr2 Otc Otc Arg1 Arg1 Cps1 Cps1 Aldh18a1 Aldh18a1 Oat Oat Nags Nags RGD1562036 RGD1562036 Pycr1 Pycr1 Iffo2 Iffo2 Pycr3 Pycr3 Gpt2 Gpt2 Arg2 Arg2 Aldh18a1-2 Aldh18a1-2 Ass1 Ass1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AslArgininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (461 aa)
Prodh1Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (599 aa)
Pycr2Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
OtcOrnithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (354 aa)
Arg1Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. (323 aa)
Cps1Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. (1500 aa)
Aldh18a1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
OatOrnithine aminotransferase, mitochondrial. (439 aa)
NagsN-acetylglutamate synthase (Predicted), isoform CRA_a. (527 aa)
RGD1562036Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
Pycr1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (359 aa)
Iffo2Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). (1463 aa)
Pycr3Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. (274 aa)
Gpt2Glutamic--pyruvic transaminase 2. (789 aa)
Arg2Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] (354 aa)
Aldh18a1-2Aldehyde dehydrogenase 18 family, member A1. (795 aa)
Ass1Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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