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| | Btrc | Beta-transducin repeat-containing E3 ubiquitin protein ligase. (587 aa) |
| | Ube2s | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] (223 aa) |
| | Trim6 | Tripartite motif-containing 6. (488 aa) |
| | Trim5 | Similar to 9230105E10Rik protein. (511 aa) |
| | Tmem129 | Transmembrane protein 129. (362 aa) |
| | Rnf186 | Ring finger protein 186. (281 aa) |
| | Marchf5 | Membrane-associated ring finger (C3HC4) 5 (Predicted). (278 aa) |
| | Cdc16 | CDC16 cell division cycle 16 homolog (S. cerevisiae). (620 aa) |
| | Anapc10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | Trim3 | Tripartite motif-containing protein 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B. (744 aa) |
| | Trim21 | Tripartite motif protein 21 (Predicted), isoform CRA_a. (471 aa) |
| | Znrf1 | RCG51260, isoform CRA_a. (227 aa) |
| | Fbxo38 | F-box protein 38. (1189 aa) |
| | Rnf185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | Rnf31 | Ring finger protein 31 (Predicted), isoform CRA_a. (1062 aa) |
| | Stub1 | STIP1 homology and U-Box containing protein 1, isoform CRA_b. (304 aa) |
| | Ube2q1 | Ubiquitin-conjugating enzyme E2Q (Putative) (Predicted), isoform CRA_a. (422 aa) |
| | Prpf19 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] (504 aa) |
| | Syvn1 | Synovial apoptosis inhibitor 1, synoviolin, isoform CRA_b. (612 aa) |
| | Marchf6 | Membrane associated ring-CH-type finger 6. (909 aa) |
| | Ubox5 | Similar to Rnf37-pending protein. (538 aa) |
| | Ube2u | Ubiquitin-conjugating enzyme E2 U. (337 aa) |
| | Nhlrc1 | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] (396 aa) |
| | Fdps | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity); Belongs to the FPP/GG [...] (879 aa) |
| | Ube2k | Huntingtin interacting protein 2 (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | Fbxl7 | F-box and leucine-rich repeat protein 7. (444 aa) |
| | Dtx3l | Deltex E3 ubiquitin ligase 3L. (750 aa) |
| | Triml2 | Tripartite motif family-like 2. (430 aa) |
| | Ppil2 | Peptidylprolyl isomerase (Cyclophilin)-like 2. (521 aa) |
| | Cdc23 | CDC23 (Cell division cycle 23, yeast, homolog), isoform CRA_b. (571 aa) |
| | Ube2v1 | Ubiquitin-conjugating enzyme E2 V1. (147 aa) |
| | F1M227_RAT | UBIQUITIN_CONJUGAT_2 domain-containing protein. (139 aa) |
| | Klhl3 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). (467 aa) |
| | Marchf1 | Membrane associated ring-CH-type finger 1. (254 aa) |
| | Ube2l6 | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. (153 aa) |
| | Ube2d4 | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection Plays a role i [...] (147 aa) |
| | Ambra1 | Autophagy and beclin 1 regulator 1. (1300 aa) |
| | Ube2j1 | Ubiquitin-conjugating enzyme E2, J1. (248 aa) |
| | Trim71 | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain pro [...] (855 aa) |
| | Ube2ql1 | Ubiquitin-conjugating enzyme E2Q family-like 1. (304 aa) |
| | D3ZL88_RAT | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa) |
| | Prame | Preferentially-expressed antigen in melanoma. (464 aa) |
| | Rnf213 | Ring finger protein 213. (5136 aa) |
| | Trim58 | Tripartite motif-containing 58. (485 aa) |
| | Ube2e2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (126 aa) |
| | Cdc26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | Arih2 | RBR-type E3 ubiquitin transferase. (492 aa) |
| | Ube2l3 | Ubiquitin-conjugating enzyme E2L 3 (Predicted). (166 aa) |
| | Daw1 | Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly. Belongs to the WD repeat WDR69 family. (415 aa) |
| | Fbxw7 | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] (713 aa) |
| | Anapc11 | Similar to anaphase promoting complex subunit 11 homolog (Predicted), isoform CRA_a. (84 aa) |
| | Trim34 | Tripartite motif-containing 34. (486 aa) |
| | Ube4b | Ubiquitination factor E4B. (1173 aa) |
| | Anapc1 | Anaphase promoting complex subunit 1 (Predicted). (1944 aa) |
| | Chfr | Checkpoint with forkhead and ring finger domains, isoform CRA_b. (663 aa) |
| | Rnf20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (973 aa) |
| | Lrsam1 | Leucine-rich repeat and sterile alpha motif-containing 1. (728 aa) |
| | Dda1 | DET1 and DDB1-associated 1. (101 aa) |
| | Aktip | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). (292 aa) |
| | Ube2a | Ubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae); Belongs to the ubiquitin-conjugating enzyme family. (162 aa) |
| | Rnf180 | Ring finger protein 180. (593 aa) |
| | Ttc3 | E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity). Positively regulates TGFB1-induced epithelial-mesenchymal [...] (2000 aa) |
| | Rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa) |
| | Trim2 | Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance. (761 aa) |
| | Ube2d3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (147 aa) |
| | Nfe2l1 | Nuclear factor, erythroid 2-like 1. (675 aa) |
| | Ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzym [...] (145 aa) |
| | Cbl | Cbl proto-oncogene. (914 aa) |
| | Topors | Topoisomerase I binding, arginine/serine-rich (Predicted). (1042 aa) |
| | Hdac6-2 | Histone deacetylase 6. (1155 aa) |
| | Fbxl17 | F-box and leucine-rich repeat protein 17 (Predicted). (303 aa) |
| | LOC103694506 | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] (146 aa) |
| | RGD1309291 | Similar to RIKEN cDNA 4930547C10. (664 aa) |
| | Ube2h | Ubiquitin-conjugating enzyme E2H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | Kbtbd6 | Kelch repeat and BTB domain-containing 6. (489 aa) |
| | Kbtbd7 | Kelch repeat and BTB domain containing 6. (489 aa) |
| | M0R6B6_RAT | UBIQUITIN_CONJUGAT_2 domain-containing protein. (150 aa) |
| | Rnf14 | RBR-type E3 ubiquitin transferase. (479 aa) |
| | Tnfaip3 | TNF alpha-induced protein 3. (814 aa) |
| | Traf5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | Rnf187 | E3 ubiquitin-protein ligase RNF187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. (236 aa) |
| | Ube3b | Ubiquitin protein ligase E3B. (1068 aa) |
| | Trim62 | Similar to tripartite motif-containing 62. (475 aa) |
| | Znrf2 | Zinc and ring finger 2. (245 aa) |
| | Rnf165 | Ring finger protein 165. (340 aa) |
| | Rffl | E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signal [...] (334 aa) |
| | Klhl20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (609 aa) |
| | Ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa) |
| | LOC100910717 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | Rnf114 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] (229 aa) |
| | Jade2 | PHD finger protein 15 (Predicted). (829 aa) |
| | Trip12 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] (2038 aa) |
| | Rbx1 | Ring-box 1. (108 aa) |
| | Pnkp | Polynucleotide kinase 3'-phosphatase. (548 aa) |
| | Rnf144b | RBR-type E3 ubiquitin transferase. (301 aa) |
| | Fbxw11 | F-box and WD repeat domain-containing 11. (531 aa) |
| | Rnf111 | Ring finger protein 111 (Predicted). (987 aa) |
| | Nedd4l | NEDD4-like E3 ubiquitin protein ligase. (961 aa) |
| | Rnf125 | Ring finger protein 125. (233 aa) |
| | Trim30c | Tripartite motif-containing 30C. (514 aa) |
| | Ube4a | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1085 aa) |
| | Zswim2 | Zinc finger, SWIM-type-containing 2. (631 aa) |
| | Ube2n | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | Mgrn1 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). (554 aa) |
| | Cdkn2a | Tumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (160 aa) |
| | Brca1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1817 aa) |
| | Rbck1 | RanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('Met- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following p [...] (508 aa) |
| | Trim14 | Tripartite motif-containing 14. (440 aa) |
| | Amfr | Autocrine motility factor receptor. (630 aa) |
| | Rnf41 | Ring finger protein 41. (317 aa) |
| | Skp1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (165 aa) |
| | Tnks2 | Tankyrase 2. (1166 aa) |
| | Smurf1 | E3 ubiquitin-protein ligase. (731 aa) |
| | Rnf19b | RBR-type E3 ubiquitin transferase. (654 aa) |
| | Cdc34 | RCG29282, isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (235 aa) |
| | Rnf4 | E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...] (196 aa) |
| | LOC100302465 | Hypothetical LOC100302465. (699 aa) |
| | Peli3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa) |
| | Traf3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (610 aa) |
| | Ube2j2 | Similar to Ubc6p homolog, isoform CRA_a. (271 aa) |
| | Nedd4 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] (889 aa) |
| | Trim27 | Tripartite motif protein 27 (Predicted), isoform CRA_b. (513 aa) |
| | Skp2 | S-phase kinase-associated protein 2 (P45). (423 aa) |
| | Itch | E3 ubiquitin-protein ligase. (882 aa) |
| | Prkn | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of mi [...] (289 aa) |
| | Bard1 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] (768 aa) |
| | Trim68 | Tripartite motif-containing 68. (490 aa) |
| | Ube3c | Ubiquitin protein ligase E3C. (962 aa) |
| | Fbxo28 | F-box protein 28 (Predicted), isoform CRA_a. (368 aa) |
| | Rnf115 | Ring finger protein 115. (305 aa) |
| | Hace1 | E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defen [...] (909 aa) |
| | Rnf5 | E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'- linked polyubiquitination [...] (180 aa) |
| | Traf3ip2 | Chromosome 6 open reading frame 4, isoform CRA_a. (558 aa) |
| | Ube2d1 | Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By [...] (147 aa) |
| | Rnf6 | Ring finger protein 6. (667 aa) |
| | Rnf216 | Similar to E3 ubiquitin ligase TRIAD3B (Predicted). (910 aa) |
| | Wsb2 | WD repeat and SOCS box-containing 2. (404 aa) |
| | Ube2g2 | Ubiquitin-conjugating enzyme E2G 2 (Predicted), isoform CRA_b; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | Anapc7 | Anaphase promoting complex subunit 7 (Predicted). (565 aa) |
| | Anapc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (740 aa) |
| | Rnf34 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (381 aa) |
| | Rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa) |
| | Klhl42 | Similar to C230080I20Rik protein (Predicted). (493 aa) |
| | Dzip3 | DAZ-interacting zinc finger protein 3. (1174 aa) |
| | Bcl2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Belongs to the Bcl-2 family. (236 aa) |
| | Bfar | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). (450 aa) |
| | Rnf167 | E3 ubiquitin-protein ligase RNF167; May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin- conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. (349 aa) |
| | Dtl | Denticleless E3 ubiquitin protein ligase homolog. (783 aa) |
| | G2e3 | G2/M-phase-specific E3 ubiquitin protein ligase. (717 aa) |
| | Anapc4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa) |
| | Traf6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (530 aa) |
| | Spop | Speckle-type POZ protein, isoform CRA_a. (374 aa) |
| | Arel1 | Apoptosis-resistant E3 ubiquitin protein ligase 1. (823 aa) |
| | Ube2e3 | Ubiquitin-conjugating enzyme E2E 3; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | Ube2t | Ubiquitin-conjugating enzyme E2T (Putative) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. (204 aa) |
| | Cul1 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. (776 aa) |
| | Ankib1 | RBR-type E3 ubiquitin transferase. (1085 aa) |
| | Cdc27 | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (824 aa) |
| | Traf2 | TNF receptor-associated factor. (497 aa) |
| | Hectd1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | Dcaf15 | DDB1 and CUL4-associated factor 15. (599 aa) |
| | Wwp1 | E3 ubiquitin-protein ligase. (918 aa) |
| | Ubr5 | E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. P [...] (2430 aa) |
| | Hdac6 | Histone deacetylase 6. (1152 aa) |
| | Peli1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | Rnf144a | RBR-type E3 ubiquitin transferase. (292 aa) |
| | Rnf26 | Ring finger protein 26. (424 aa) |
| | Cul5 | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (855 aa) |
| | Anapc13 | Anaphase-promoting complex subunit 13. (74 aa) |
| | Ube2e1 | Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (173 aa) |
| | Ifi27 | Interferon, alpha-inducible protein 27. (182 aa) |
| | Rnf126 | Ring finger protein 126. (313 aa) |
| | Rc3h2 | Membrane associated DNA binding protein (Predicted). (1187 aa) |
| | Mkrn1 | Makorin ring finger protein 1. (481 aa) |
| | Mkrn2 | Makorin, ring finger protein, 2. (417 aa) |
| | Rnf19a | RBR-type E3 ubiquitin transferase. (840 aa) |
| | Magel2 | MAGE family member L2. (1258 aa) |
| | Ube2g1 | Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | Arih1 | RBR-type E3 ubiquitin transferase. (555 aa) |
| | Ercc8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) |
| | Trim32 | Tripartite motif-containing 32. (655 aa) |
| | Birc2 | Baculoviral IAP repeat-containing 2. (589 aa) |
| | Nhlrc3 | NHL repeat-containing 3. (386 aa) |
| | Ube3d | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (370 aa) |
| | Ube2o | Ubiquitin-conjugating enzyme E2O. (1138 aa) |
| | Anapc2 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. (836 aa) |
| | Rnf146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa) |
| | Ube2r2 | Ubiquitin-conjugating enzyme E2R 2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | Tnks | Poly [ADP-ribose] polymerase. (1317 aa) |
| | Peli2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (419 aa) |
| | Ube2b | Ubiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-l [...] (180 aa) |
| | Zfp91 | Zinc finger protein 91. (568 aa) |
| | Marchf8 | Membrane-associated ring finger (C3HC4) 8 (Predicted). (286 aa) |
| | Sash1 | SAM and SH3 domain-containing 1. (1073 aa) |
| | Hecw2 | Similar to HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 isoform 1. (1578 aa) |
| | Rnf217 | RBR-type E3 ubiquitin transferase. (402 aa) |
| | Wsb1 | WD repeat and SOCS box-containing 1, isoform CRA_b. (421 aa) |
| | Map3k1 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. (1493 aa) |
| | Sharpin | Sharpin; Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BI [...] (381 aa) |
| | Rnf166 | E3 ubiquitin-protein ligase RNF166; E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Plays also a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys- 29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. (237 aa) |
| | Wwp2 | WW domain-containing E3 ubiquitin protein ligase 2. (759 aa) |
| | Ddb2 | Damage-specific DNA-binding protein 2. (432 aa) |
| | Irf2bp1 | Interferon regulatory factor 2 binding protein 1 (Predicted). (584 aa) |
| | Triml1 | Tripartite motif family-like 1. (470 aa) |
| | Ube2q2 | Ubiquitin-conjugating enzyme E2Q family member 2. (376 aa) |
| | Cbfb | Core-binding factor, beta subunit. (182 aa) |
| | Smurf2 | SMAD-specific E3 ubiquitin protein ligase 2. (637 aa) |
| | Shprh | SNF2 histone linker PHD RING helicase (Predicted). (1701 aa) |
| | Rnf152 | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. Belongs to the RNF152 family. (203 aa) |
| | Rnf183 | Ring finger protein 183. (190 aa) |
| | Fbxo22 | RCG58340, isoform CRA_b. (399 aa) |
| | Ube2c | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | Fbxo4 | F-box only protein 4 (Predicted). (431 aa) |
| | Ube3a | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (868 aa) |
| | Cul3 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the [...] (746 aa) |
| | Hecw1 | Similar to HECT type E3 ubiquitin ligase (Predicted), isoform CRA_b. (1594 aa) |
| | Mul1 | Similar to RIKEN cDNA 0610009K11 (Predicted), isoform CRA_b. (352 aa) |
