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| | Kcnip2 | Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart (By similarity). Required for normal protein levels of KCND2 in the heart ventricle (By similarity). Belongs to the recoverin family. (270 aa) |
| | Zfp952 | Uncharacterized protein. (461 aa) |
| | Irx1 | Iroquois homeobox 1. (480 aa) |
| | Mxi1 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. (228 aa) |
| | Tfap2a | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and c-Myc. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITE [...] (431 aa) |
| | Prdm1 | PR/SET domain 1. (824 aa) |
| | Zbtb16 | Promyelocytic leukemia zinc finger protein. (673 aa) |
| | Zbtb34 | Zinc finger and BTB domain-containing 34. (518 aa) |
| | Nr3c1 | Glucocorticoid receptor. (382 aa) |
| | Rela | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (550 aa) |
| | Lrrfip1 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Belongs to the LRRFIP family. (738 aa) |
| | Cdx2 | Caudal type homeo box 2. (310 aa) |
| | Peg3 | RCG32052, isoform CRA_a. (1579 aa) |
| | Prdm2 | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA- responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene (By similarity). (1706 aa) |
| | Deaf1 | Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branchin [...] (565 aa) |
| | Hsf1 | Heat shock transcription factor 1. (525 aa) |
| | Zbtb21 | Zinc finger protein 295 (Predicted), isoform CRA_a. (886 aa) |
| | LOC100910807 | Transcriptional regulator Kaiso-like. (670 aa) |
| | Klf16 | Kruppel-like factor 16. (251 aa) |
| | Zfp663 | Zinc finger protein 663. (664 aa) |
| | Nkx6-2 | NK6 transcription factor related, locus 2 (Drosophila) (Predicted). (277 aa) |
| | Foxk2 | Forkhead box K2 (Predicted), isoform CRA_a. (400 aa) |
| | Hdac5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (947 aa) |
| | Srebf2 | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'- ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity); Belongs to the SREBP family. (1133 aa) |
| | Dmbx1 | Diencephalon/mesencephalon homeobox 1 (Predicted), isoform CRA_a. (376 aa) |
| | Zbtb24 | Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription. Belongs to the krueppel C2H2-type zinc-finger protein family. (705 aa) |
| | Gpr182 | G-protein coupled receptor 182; Orphan receptor. (398 aa) |
| | Nfatc1 | Nuclear factor of-activated T-cells 1. (827 aa) |
| | Mzf1 | RCG27468, isoform CRA_c. (735 aa) |
| | E2f6 | E2F transcription factor 6. (272 aa) |
| | Nfx1 | Nuclear transcription factor, X-box-binding 1. (1114 aa) |
| | Isx | Intestine-specific homeobox. (242 aa) |
| | Rorc | RAR-related orphan receptor C. (487 aa) |
| | Hoxd9 | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (332 aa) |
| | Zbtb32 | Zinc finger and BTB domain-containing 32. (483 aa) |
| | Nfatc2 | Nuclear factor of-activated T-cells 2. (931 aa) |
| | Tbx15 | T-box transcription factor 15. (602 aa) |
| | Ovol2 | Zinc finger protein 339 (Predicted), isoform CRA_b. (241 aa) |
| | Nfe2l1 | Nuclear factor, erythroid 2-like 1. (675 aa) |
| | Crem | cAMP-responsive element modulator; Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (By similarity). (357 aa) |
| | Nanog | Nanog homeobox. (312 aa) |
| | Bach2 | BTB domain and CNC homolog 2. (839 aa) |
| | Hes6 | Hairy and enhancer of split 6 (Drosophila). (234 aa) |
| | Znf750 | Zinc finger protein 750. (710 aa) |
| | Bhlhe41 | Class E basic helix-loop-helix protein 41; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodime [...] (397 aa) |
| | Snai2 | Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of [...] (268 aa) |
| | Zfp566 | Zinc finger protein 566. (386 aa) |
| | Nr2e1 | Nuclear receptor subfamily 2, group E, member 1. (385 aa) |
| | Prdm16 | PR/SET domain 16. (1091 aa) |
| | Pou5f1 | POU domain protein. (352 aa) |
| | Zfp617 | Zinc finger protein 617. (422 aa) |
| | Zbtb33 | Zinc finger and BTB domain containing 33. (670 aa) |
| | Hsf4 | Heat shock transcription factor 4. (489 aa) |
| | Zfp41 | Zinc finger protein 41. (198 aa) |
| | Zfp9-2 | Zinc finger protein 9. (576 aa) |
| | Mxd3 | RAB24, member RAS oncogene family. (203 aa) |
| | Zbtb37 | Zinc finger and BTB domain containing 37 (Predicted). (504 aa) |
| | En1 | Homeobox protein engrailed-like. (399 aa) |
| | Zbtb49 | Zinc finger and BTB domain-containing 49. (758 aa) |
| | Nfatc3 | Nuclear factor of-activated T-cells 3. (1076 aa) |
| | Sox6 | SRY-box containing gene 6, isoform CRA_b. (854 aa) |
| | Sp5 | Trans-acting transcription factor 5 (Predicted). (398 aa) |
| | Foxp2 | Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels. (710 aa) |
| | Purb | Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to it [...] (317 aa) |
| | Ikzf1 | Similar to DNA-binding protein Ikaros form 1-mouse (Predicted), isoform CRA_a. (514 aa) |
| | Ppard | Peroxisome proliferator activated receptor delta, isoform CRA_b. (440 aa) |
| | Gtf2ird1 | GTF2I repeat domain-containing 1. (1073 aa) |
| | Foxp4 | Forkhead box P4. (671 aa) |
| | Zfp763 | Zinc finger protein 763. (580 aa) |
| | Zfp217 | Zinc finger protein 217 (Predicted). (1039 aa) |
| | Zbtb10 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation. (836 aa) |
| | Tcfl5 | Transcription factor-like 5. (489 aa) |
| | Pax6 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains; Belongs to the paired homeobox family. (433 aa) |
| | Nkx3-2 | NK3 homeobox 2. (320 aa) |
| | Zfp148 | Zinc finger protein 148; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. (794 aa) |
| | Ovol1 | Ovo-like transcriptional repressor 1. (267 aa) |
| | Bcl6b | BCL6B, transcription repressor. (472 aa) |
| | Zfp819 | Similar to RIKEN cDNA 4933405K07. (614 aa) |
| | Atf3 | Cyclic AMP-dependent transcription factor ATF-3; In solution, it binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters but also has affinity for related sites. May have a unique and critical role in growth regulation of regenerating liver and mitogen-stimulated cells. (181 aa) |
| | Tcf3 | Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B- cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs. (649 aa) |
| | Cebpb | CCAAT/enhancer-binding protein beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (By similarity). Has a promitotic effect on many cell types such as hepa [...] (297 aa) |
| | Zfp955a | Zinc finger protein 955A. (591 aa) |
| | Kcnip3 | Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity); Belongs to the recoverin family. (256 aa) |
| | Thap1 | THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). (210 aa) |
| | Nr2c1 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early emb [...] (590 aa) |
| | Bach1 | BTB and CNC homology 1 (Predicted), isoform CRA_b. (739 aa) |
| | Zfp692 | Zinc finger protein 692. (565 aa) |
| | Max | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity). (160 aa) |
| | Sp2 | Sp2 transcription factor. (612 aa) |
| | St18 | Suppression of tumorigenicity 18 protein; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters; Belongs to the MYT1 family. (1044 aa) |
| | Zbtb1 | Zinc finger and BTB domain-containing 1. (644 aa) |
| | Zfp281 | Zinc finger protein 281. (890 aa) |
| | Hic2 | Hypermethylated in cancer 2 (Predicted). (622 aa) |
| | Myef2 | Myelin expression factor 2. (591 aa) |
| | Zkscan3 | Zinc finger with KRAB and SCAN domains 3. (554 aa) |
| | Tfec | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate- resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By si [...] (317 aa) |
| | Eno1 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. (434 aa) |
| | Sp3 | Sp3 transcription factor. (714 aa) |
| | LOC100912262 | GTF2I repeat domain-containing 1. (1105 aa) |
| | Ski | Similar to Ski protein (Predicted). (699 aa) |
| | Foxp3 | Forkhead box P3 isoform 2. (488 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | LOC100912068 | Hypermethylated in cancer 1 protein-like. (740 aa) |
| | Hoxa2-2 | Homeobox A2. (372 aa) |
| | Pou4f1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N- terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects ne [...] (417 aa) |
| | Zfp202 | Zinc finger protein 202. (643 aa) |
| | Arx | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Belongs to the paired homeobox family. Bicoid subfamily. (565 aa) |
| | Zfp709 | Zinc finger protein HIT-40. (736 aa) |
| | Nr1d2 | Nuclear receptor subfamily 1 group D member 2; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 co [...] (578 aa) |
| | Mnt | MAX network transcriptional repressor. (590 aa) |
| | Zbtb20 | Zinc finger and BTB domain containing 20 (Predicted), isoform CRA_c. (741 aa) |
| | Pou4f2 | POU domain, class 4, transcription factor 2; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooper [...] (412 aa) |
| | Smad5 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa) |
| | Foxo3 | Forkhead box O3a (Predicted). (672 aa) |
| | Zbtb12 | Zinc finger and BTB domain-containing 12. (459 aa) |
| | Neurog3 | Neurogenin 3. (214 aa) |
| | Zfp358 | Zinc finger protein 358. (652 aa) |
| | Foxk1 | Forkhead box K1. (616 aa) |
| | Pcbp3 | Poly(rC)-binding protein 3. (319 aa) |
| | Irx2 | Iroquois homeobox 2. (474 aa) |
| | Zbtb5 | Zinc finger and BTB domain containing 5 (Predicted), isoform CRA_a. (670 aa) |
| | Cux2 | Homeobox protein cut-like. (1426 aa) |
| | Mafk | V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (Avian). (156 aa) |
| | Hdgf | Hepatoma-derived growth factor; Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). (237 aa) |
| | Satb1 | DNA-binding protein SATB. (764 aa) |
| | Vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina; Belongs to the EMX homeobox family. (292 aa) |
| | LOC100363405 | Zinc finger protein 37; May be involved in transcriptional regulation. (583 aa) |
| | Foxo1 | Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (649 aa) |
| | Tmem9b | TMEM9 domain family, member B (Predicted), isoform CRA_b. (199 aa) |
| | Snai3 | Snail family transcriptional repressor 3. (287 aa) |
| | Sall1 | Spalt-like transcription factor 1. (1315 aa) |
| | Hey2 | Hes-related family bHLH transcription factor with YRPW motif 2. (339 aa) |
| | Hes5 | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). (166 aa) |
| | Aebp1 | Adipocyte enhancer-binding protein 1; As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix (By similarity). May positively regulate MAP- kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. (1127 aa) |
| | Zfp536 | Zinc finger protein 536. (1305 aa) |
| | Mypop | Myb-related transcription factor, partner of profilin. (392 aa) |
| | Zgpat | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). (507 aa) |
| | Hesx1 | Similar to anterior-restricted homeobox protein (Predicted). (185 aa) |
| | Zfp810 | Zinc finger protein 810. (415 aa) |
| | Hivep1 | HIVEP zinc finger 1. (2110 aa) |
| | Zfhx3 | Zinc finger homeobox 3. (3730 aa) |
| | Nr3c1-2 | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (413 aa) |
| | Zbtb4 | Zinc finger and BTB domain-containing protein 4; Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in [...] (984 aa) |
| | Glis3 | GLIS family zinc finger 3. (935 aa) |
| | Nr2f1 | Nuclear receptor subfamily 2, group F, member 1. (420 aa) |
| | Zbtb46 | BTB (POZ) domain containing 4 (Predicted). (601 aa) |
| | Zfp512b | Uridine kinase-like 1 (Predicted). (875 aa) |
| | Heyl | Hes-related family bHLH transcription factor with YRPW motif-like. (326 aa) |
| | Tgif1 | TGFB-induced factor homeobox 1. (287 aa) |
| | Etv3 | ETS variant transcription factor 3. (513 aa) |
| | Zfp131 | Zinc finger protein 131, isoform CRA_a. (619 aa) |
| | Zfp865 | Similar to zinc finger protein ZFP (Predicted). (324 aa) |
| | Ets2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa) |
| | Hes1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (281 aa) |
| | Bcl6 | B-cell leukemia/lymphoma 6 (Predicted). (707 aa) |
| | Gfi1 | Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. [...] (423 aa) |
| | Rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (By similarity). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Trans [...] (1086 aa) |
| | Nkx6-1 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). (365 aa) |
| | Hand1 | Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (216 aa) |
| | Hic1 | HIC ZBTB transcriptional repressor 1. (535 aa) |
| | Zfp13 | Zinc finger protein 13 (Predicted). (399 aa) |
| | Tbx2 | T-box 2 (Predicted), isoform CRA_a. (364 aa) |
| | Prop1 | PROP paired-like homeobox 1. (223 aa) |
| | Prox1 | Prospero homeobox 1. (654 aa) |
| | Prrx1 | Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). (245 aa) |
| | Batf3 | Basic leucine zipper transcriptional factor ATF-like 3; AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8- alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Belongs [...] (133 aa) |
| | Ascl1 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG- 3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mo [...] (233 aa) |
| | Zbtb39 | Zinc finger and BTB domain containing 39 (Predicted). (711 aa) |
| | Yy1 | Transcription factor YY1. (411 aa) |
| | Dlx4 | Distal-less homeobox 4 (Predicted). (238 aa) |
| | Zbtb18 | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May [...] (522 aa) |
| | Myt1l | Myelin transcription factor 1-like protein; Transcription factor that plays a key role in neuronal differentiation. Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 [...] (1182 aa) |
| | Elk3 | ELK3, member of ETS oncogene family (Predicted), isoform CRA_a. (408 aa) |
| | Pou6f1 | POU domain, class 6, transcription factor 1; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'); Belongs to the POU transcription factor family. Class-6 subfamily. (301 aa) |
| | Myc | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (By similarity). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | Gzf1 | GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. (707 aa) |
| | Zeb2 | Zinc finger E-box-binding homeobox 2. (1215 aa) |
| | Zfp3 | Zinc finger protein 3. (503 aa) |
| | Tfap2c | Transcription factor AP-2, gamma. (450 aa) |
| | Creb3l1 | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...] (520 aa) |
| | Etv6 | ETS variant transcription factor 6. (453 aa) |
| | Sox30 | SRY (sex determining region Y)-box 30. (764 aa) |
| | Tcf7 | Transcription factor 7. (449 aa) |
| | Hoxa2 | Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa) |
| | LOC102554315 | Zinc finger protein 596-like. (410 aa) |
| | Zbtb25 | Zinc finger and BTB domain containing 25, isoform CRA_a. (438 aa) |
| | Zfp398 | Similar to zinc finger protein 398 (Predicted). (643 aa) |
| | Zfp746 | Zinc finger protein 746. (650 aa) |
| | F1M5G7_RAT | Uncharacterized protein. (516 aa) |
| | Bcl11a | BAF chromatin-remodeling complex subunit BCL11A. (835 aa) |
| | Bhlhe40 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] (411 aa) |
| | Prdm5 | Zinc finger protein. (558 aa) |
| | Cc2d1a | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity). (941 aa) |
| | Msc | Musculin. (203 aa) |
| | Hoxb13 | Homeo box B13 (Predicted). (286 aa) |
| | Hoxb8 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (243 aa) |
| | Fezf1 | Similar to zinc finger protein 312 (Predicted). (475 aa) |
| | Zfp263 | Zinc finger protein 263. (680 aa) |
| | Pax4 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity); Belongs to the paired homeobox family. (349 aa) |
| | Jph2 | Junctophilin-2 N-terminal fragment; [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross- talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ry [...] (692 aa) |
| | Zbtb8a | Zinc finger and BTB domain-containing protein 8A; May be involved in transcriptional regulation. (441 aa) |
| | Foxs1 | Forkhead box S1. (327 aa) |
| | Jdp2 | Jun dimerization protein 2; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV- induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity). (163 aa) |
| | Tbx3 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity). (743 aa) |
| | Cc2d1b | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. (850 aa) |
| | Jun | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. (334 aa) |
| | Vax1 | Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity); Belongs to the EMX homeobox family. (336 aa) |
| | Dach1 | Dachshund family transcription factor 1. (531 aa) |
| | Hbp1 | HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). (523 aa) |
| | Pparg | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | Hmx1 | H6 homeo box 1 (Predicted), isoform CRA_b. (333 aa) |
| | Zbtb6 | Zinc finger and BTB domain-containing 6. (423 aa) |
| | Klf12 | Kruppel-like factor 12 (Predicted), isoform CRA_a. (419 aa) |
| | Zbtb26 | Zinc finger and BTB domain containing 26 (Predicted), isoform CRA_a. (451 aa) |
| | Fezf2 | Zinc finger protein 312 (Predicted). (455 aa) |
| | E4f1 | E4F transcription factor 1. (783 aa) |
| | Nr1d1 | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] (614 aa) |
| | Tbx21 | T-box transcription factor 21. (528 aa) |
| | Hinfp | Histone H4 transcription factor. (514 aa) |
| | Snai1 | Snail family transcriptional repressor 1. (264 aa) |
| | Skil | SKI-like proto-oncogene. (677 aa) |
| | Foxp1 | Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neur [...] (711 aa) |
| | Lef1 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). (397 aa) |
| | Hes2 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. (157 aa) |
| | Otp | Orthopedia homolog (Drosophila), isoform CRA_a. (325 aa) |
| | Gsc | Goosecoid homeobox. (256 aa) |
| | Helt | Helt bHLH transcription factor. (240 aa) |
| | Zbtb17 | Zinc finger and BTB domain-containing 17. (801 aa) |
| | Hes3 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. (175 aa) |
| | Tbx18 | T-box18 (Predicted), isoform CRA_a. (612 aa) |
| | Ferd3l | Fer3-like bHLH transcription factor. (166 aa) |
| | Nfe2l3 | Nuclear factor, erythroid 2-like 3. (647 aa) |
| | Irx6 | Similar to iroquois homeobox protein 6 (Predicted). (443 aa) |
| | Zfp219 | Zinc finger protein 219, isoform CRA_a. (726 aa) |
| | Nfil3 | Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa) |
| | Irx3 | Iroquois related homeobox 3 (Drosophila) (Predicted), isoform CRA_b. (326 aa) |
| | Zfp136 | Zinc finger protein 136. (554 aa) |
| | Hhex | Hematopoietically-expressed homeobox. (246 aa) |
| | Zfp161 | Zinc finger protein 161. (449 aa) |
| | Zfp668 | Zinc finger protein 668. (619 aa) |
| | Tcf21 | Transcription factor 21, isoform CRA_b. (179 aa) |
| | Nr2f6 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcripti [...] (390 aa) |
| | Zfp169 | Zinc finger protein 169. (764 aa) |
| | Zc3h8 | Zinc finger CCCH type-containing 8. (305 aa) |
| | Ctcf | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] (738 aa) |
| | Mxd1 | Max dimerization protein 1. (232 aa) |
| | Irf8 | Interferon regulatory factor 8. (424 aa) |
| | Zeb1 | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'- CANNTG-3'). Promotes tumorige [...] (1089 aa) |
| | Nkx6-3 | NK6 homeobox 3. (262 aa) |
| | LOC102556967 | Zinc finger protein 484-like. (726 aa) |
| | LOC100911951 | Kv channel-interacting protein 2x. (252 aa) |
| | Msx2 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa) |
| | Nacc2 | Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity). (585 aa) |
| | Patz1 | POZ (BTB) and AT hook-containing zinc finger 1. (641 aa) |
| | Mkx | Mohawk homeobox. (315 aa) |
| | Thap11 | THAP domain containing 11 (Predicted). (308 aa) |
| | Zfp180 | Zinc finger protein 180, isoform CRA_b. (650 aa) |
| | Gata3 | GATA-binding protein 3. (444 aa) |
| | Zfp61 | Zinc finger protein 61. (552 aa) |
| | Klf17 | Kruppel-like factor 17. (340 aa) |
| | Zbtb2 | Zinc finger and BTB domain containing 2 (Predicted). (514 aa) |
| | Mlx | MAX-like protein X, isoform CRA_a. (298 aa) |
| | Zfp90 | Zinc finger protein 90; Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. (633 aa) |
| | Zbtb7a | Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (By similarity). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms. That is, recru [...] (569 aa) |
| | Erf | Ets2 repressor factor. (552 aa) |
| | Ascl2 | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. (260 aa) |
| | Nfatc4 | Nuclear factor of activated T-cells, cytoplasmic 4; Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in heart physiology. Along with GATA4, binds to and acti [...] (901 aa) |
| | Zfp84 | Zinc finger protein 84. (813 aa) |
| | Vsx2 | Ceh-10 homeo domain containing homolog (C. elegans), isoform CRA_a. (361 aa) |
| | Spi1 | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). (271 aa) |
| | Zfp382 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. (566 aa) |
| | Esrra | Steroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle; Belongs to the nuclear hormone receptor family. NR3 subfamily. (422 aa) |
| | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (973 aa) |
| | Sox13 | SRY (Sex determining region Y)-box 13 (Predicted), isoform CRA_a. (612 aa) |
| | Scrt1 | Scratch homolog 1, zinc finger protein (Drosophila) (Predicted). (348 aa) |
| | Zfp282 | Zinc finger protein 282 (Predicted), isoform CRA_b. (666 aa) |
| | E2f7 | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in po [...] (514 aa) |
| | Zbtb45 | Zinc finger protein 499 (Predicted), isoform CRA_a. (519 aa) |
| | Zhx3 | Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA; Belongs to the ZHX family. (951 aa) |
| | Zfp958-2 | Uncharacterized protein. (464 aa) |
| | Zfp949 | Similar to tripartite motif-containing 43 (Predicted), isoform CRA_a. (603 aa) |
| | Zfp777 | Similar to KIAA1285 protein (Predicted). (837 aa) |
| | Glis1 | GLIS family zinc finger 1. (708 aa) |
| | Ikzf5 | Zinc finger protein, subfamily 1A, 5 (Predicted), isoform CRA_b. (419 aa) |
| | Zfp157 | Zinc finger protein 157. (568 aa) |
| | E2f8 | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta a [...] (876 aa) |
| | Zfp78 | Zinc finger protein 78. (513 aa) |
| | RGD1566386 | Similar to Hypothetical protein A430033K04. (677 aa) |
| | Zfp133 | Zinc finger protein 133. (544 aa) |
| | Zfp69 | RCG30900, isoform CRA_b. (427 aa) |
| | Ppara | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (468 aa) |
| | Trps1 | Trichorhinophalangeal syndrome I (Predicted). (1281 aa) |
