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| | Arhgef1 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12 (By similarity). Mediates angiotensin-2- induced RhoA activation. (918 aa) |
| | Sgsm2 | Small G protein-signaling modulator 2. (1050 aa) |
| | Elmod3 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. (381 aa) |
| | Arhgap24 | Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] (657 aa) |
| | Sipa1l1 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. (1782 aa) |
| | Rasgrp3 | RAS guanyl-releasing protein 3. (691 aa) |
| | Tbc1d14 | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. (722 aa) |
| | Prex2 | Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1598 aa) |
| | Tbck | TBC1 domain-containing kinase. (894 aa) |
| | Tbc1d8b | TBC1 domain family member 8B. (1118 aa) |
| | Nrp1 | Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (By similarity). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron [...] (922 aa) |
| | Tbc1d9 | TBC1 domain family member 9. (1262 aa) |
| | Dlc1 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). (1125 aa) |
| | Arhgef12 | Rho guanine nucleotide exchange factor 12. (1532 aa) |
| | Agap1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. (889 aa) |
| | Asap2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (844 aa) |
| | Adap1 | ArfGAP with dual PH domains 1. (414 aa) |
| | Arhgap5 | Rho-GTPase-activating protein 5. (1503 aa) |
| | Arap2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2. (1671 aa) |
| | Agfg2 | ArfGAP with FG repeats 2. (488 aa) |
| | Tbc1d5 | TBC1 domain family, member 5. (827 aa) |
| | Rgs8 | Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. (232 aa) |
| | Depdc5 | DEP domain-containing 5, GATOR1 subcomplex subunit. (1591 aa) |
| | LOC365791 | Similar to T-cell activation Rho GTPase-activating protein isoform b. (834 aa) |
| | tGap1 | GTPase-activating protein testicular GAP1. (1387 aa) |
| | Acap3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (833 aa) |
| | Tbc1d24 | TBC1 domain family, member 24. (562 aa) |
| | Git1 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTP [...] (752 aa) |
| | Rinl | Similar to RIKEN cDNA 5830482F20 gene (Predicted). (568 aa) |
| | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). (809 aa) |
| | Rgs14 | Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pa [...] (544 aa) |
| | Arfgap3 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (522 aa) |
| | Als2 | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. (1651 aa) |
| | Ocrl | Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] (902 aa) |
| | Agap3 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (812 aa) |
| | Arhgap12 | Rho GTPase-activating protein 12. (838 aa) |
| | Rap1gds1 | RAP1, GTP-GDP dissociation stimulator 1 (Predicted), isoform CRA_a. (527 aa) |
| | Rap1gap2 | RAP1 GTPase-activating protein 2. (731 aa) |
| | Nprl3 | NPR3-like, GATOR1 complex subunit. (582 aa) |
| | Rin3 | Ras and Rab interactor 3. (980 aa) |
| | Arhgef11 | Rho guanine nucleotide exchange factor 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity). (1576 aa) |
| | Rasgrf1 | Ras-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP. (1244 aa) |
| | Myo9b | Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase acti [...] (2016 aa) |
| | Stard8 | StAR-related lipid transfer domain-containing 8. (1014 aa) |
| | Chn2 | Beta-chimaerin; GTPase-activating protein for p21-rac. (460 aa) |
| | Rab3gap1 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. (769 aa) |
| | Garnl3 | GTPase-activating Rap/RanGAP domain-like 3. (1035 aa) |
| | Gdi1 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. (447 aa) |
| | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). (1086 aa) |
| | Tbc1d22b | TBC1 domain family, member 22B. (483 aa) |
| | Rasa3 | Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) (By similarity). (834 aa) |
| | Tbc1d21 | TBC1 domain family, member 21. (336 aa) |
| | Arhgap4 | Rho GTPase activating protein 4, isoform CRA_a. (955 aa) |
| | Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1536 aa) |
| | Rp2 | RP2 activator of ARL3 GTPase. (409 aa) |
| | Rgs6 | Regulator of G-protein-signaling 6. (421 aa) |
| | Nckap1l | NCK-associated protein 1-like. (1134 aa) |
| | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] (1071 aa) |
| | Rapgef2 | Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] (1657 aa) |
| | Llgl2 | LLGL scribble cell polarity complex component 2. (1077 aa) |
| | Arhgap22 | Rho GTPase-activating protein 22. (700 aa) |
| | Abr | Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] (842 aa) |
| | Dab2ip | Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...] (1161 aa) |
| | Rasal2 | RAS protein activator-like 2. (1279 aa) |
| | Racgap1 | Rac GTPase-activating protein 1 (Predicted). (626 aa) |
| | LOC102554034 | ELMO domain-containing protein 2-like. (293 aa) |
| | Smap1 | Small ArfGAP 1. (440 aa) |
| | Arhgef10l | Rho guanine nucleotide exchange factor (GEF) 10-like. (1279 aa) |
| | Tbc1d12 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. (693 aa) |
| | Grtp1 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). (289 aa) |
| | Tbc1d16 | TBC1 domain family, member 16. (765 aa) |
| | Arhgap19 | Rho GTPase-activating protein 19. (494 aa) |
| | Asap3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (903 aa) |
| | Rgs7 | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. (451 aa) |
| | Arhgap28 | Rho GTPase-activating protein 28. (725 aa) |
| | Sec23b | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa) |
| | Arhgap21 | Rho GTPase-activating protein 21. (1955 aa) |
| | Chn1 | N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. (423 aa) |
| | Tiam2 | TIAM Rac1-associated GEF 2. (1714 aa) |
| | Rasal3 | Similar to Ras GTPase-activating protein nGAP (RAS protein activator like 1) (Predicted). (1015 aa) |
| | Rin2 | Ras and Rab interactor 2 (Predicted), isoform CRA_c. (902 aa) |
| | Arhgap1 | Rho GTPase-activating protein 1. (439 aa) |
| | Tbc1d15 | TBC1 domain family, member 15. (688 aa) |
| | Evi5 | Ecotropic viral integration site 5. (809 aa) |
| | Arhgap45 | Histocompatibility (Minor) HA-1 (Predicted), isoform CRA_b. (1116 aa) |
| | Dock2 | Uncharacterized protein; Belongs to the DOCK family. (846 aa) |
| | D3ZRJ5_RAT | Uncharacterized protein. (1297 aa) |
| | Dock5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1868 aa) |
| | RGD1563562 | Similar to GTPase-activating protein testicular GAP1. (1290 aa) |
| | D3Z8H5_RAT | Rho-GAP domain-containing protein. (532 aa) |
| | Arhgap9 | Rho GTPase-activating protein 9. (639 aa) |
| | LOC691044 | Uncharacterized protein. (713 aa) |
| | F1M6I2_RAT | Uncharacterized protein. (796 aa) |
| | Arfgap2 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (520 aa) |
| | Pgam5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. (288 aa) |
| | Adap2 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Binding of phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity. Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity). (378 aa) |
| | RGD1306519 | Similar to T-cell activation Rho GTPase-activating protein isoform b. (538 aa) |
| | Arfgap1 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] (425 aa) |
| | Arhgdia | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] (204 aa) |
| | Tbcd | Tubulin folding cofactor D. (1197 aa) |
| | Arhgap39 | Rho GTPase-activating protein 39. (1109 aa) |
| | Nf1 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (By similarity). (2808 aa) |
| | Rangap1 | RAN GTPase-activating protein 1. (586 aa) |
| | Rabep1 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. (862 aa) |
| | Arhgap40 | Rho GTPase-activating protein 40. (672 aa) |
| | Stxbp5 | Syntaxin-binding protein 5; Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding; Belongs to the WD repeat L(2)GL family. (1152 aa) |
| | Rap1gap | Rap1 GTPase-activating protein. (753 aa) |
| | Git2 | G protein-coupled receptor kinase interacting ArfGAP 2. (759 aa) |
| | Tbc1d9b | TBC1 domain family member 9B. (1262 aa) |
| | Rasa1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity). (996 aa) |
| | Arhgap6 | Rho GTPase-activating protein 6. (737 aa) |
| | Usp6nl | USP6 N-terminal like (Predicted), isoform CRA_a. (816 aa) |
| | Nprl2 | Tumor suppressor candidate 4, isoform CRA_a. (380 aa) |
| | Arrb1 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] (418 aa) |
| | Rgs12 | Regulator of G-protein signaling 12; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. (1457 aa) |
| | Stxbp5l | Syntaxin-binding protein 5-like. (1090 aa) |
| | Syngap1 | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. (1308 aa) |
| | Arhgap15 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). (482 aa) |
| | Sipa1l3 | Signal-induced proliferation-associated 1-like 3. (1776 aa) |
| | Arhgap17 | Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere (By similarity). Participates in the C [...] (858 aa) |
| | Rab3gap2 | Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. (1389 aa) |
| | Elmod2 | ELMO domain-containing 2. (293 aa) |
| | Arhgap42 | Rho GTPase-activating protein 42. (826 aa) |
| | Arap1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1443 aa) |
| | Ophn1 | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation. (802 aa) |
| | Gmip | Gem-interacting protein (Predicted). (969 aa) |
| | Arhgap27 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. (869 aa) |
| | Arhgap20 | Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (1182 aa) |
| | Arhgap33 | Rho GTPase-activating protein 33. (1310 aa) |
| | Ralbp1 | RalA-binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4- dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off [...] (647 aa) |
| | Tbc1d1 | TBC1 domain family member 1. (1257 aa) |
| | Arhgap23 | Rho GTPase-activating protein 23. (1457 aa) |
| | Syde2 | Synapse defective Rho GTPase homolog 2. (1171 aa) |
| | Rundc1 | RUN domain-containing 1. (615 aa) |
| | Rgs16 | Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. (199 aa) |
| | Agap2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. (1186 aa) |
| | Tbc1d2b | TBC1 domain family, member 2B. (837 aa) |
| | Iqgap2 | IQ motif-containing GTPase-activating protein 2. (1425 aa) |
| | Tbc1d10c | Similar to DKFZP434P1750 protein (Predicted). (446 aa) |
| | Iqgap3 | IQ motif-containing GTPase-activating protein 3. (1632 aa) |
| | Cdc42ep2 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. (214 aa) |
| | Sipa1 | Signal-induced proliferation-associated 1. (1040 aa) |
| | Tbc1d17 | TBC1 domain family, member 17 (Predicted). (646 aa) |
| | Rgs10 | Regulator of G-protein signaling 10; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. (181 aa) |
| | Rin1 | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). Belongs to the RIN (Ras int [...] (798 aa) |
| | Sipa1l2 | Signal-induced proliferation-associated 1-like protein 2. (1722 aa) |
| | Plekhg6 | Pleckstrin homology and RhoGEF domain-containing G6. (781 aa) |
| | Adprhl1 | [Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (353 aa) |
| | Tagap | T-cell activation GTPase activating protein (Predicted), isoform CRA_b. (714 aa) |
| | Sgsm3 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. May act as a modulator of small G protein RAB- and RAP-mediated neuronal signal transduction and vesicular transportation pathways (By similarity). (763 aa) |
| | Lars1 | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa) |
| | Rabep2 | Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. (554 aa) |
| | Gdi2 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (445 aa) |
| | Tbc1d30 | TBC1 domain family, member 30. (758 aa) |
| | Htr2b | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity o [...] (479 aa) |
| | Tbc1d10b | TBC1 domain family, member 10b (Predicted). (795 aa) |
| | Mtss2 | MTSS I-BAR domain-containing 2. (715 aa) |
| | Tbc1d22a | TBC1 domain family, member 22a. (372 aa) |
| | Rgs19 | Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity). (216 aa) |
| | Wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | Tbc1d13 | TBC1 domain family, member 13. (400 aa) |
| | Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (740 aa) |
| | Agfg1 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity). (560 aa) |
| | Arhgap35 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similar [...] (1513 aa) |
| | Ralgapb | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. (1485 aa) |
| | Gnaq | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa) |
| | Tbc1d7 | TBC1 domain family, member 7. (293 aa) |
| | Arhgap26 | Rho GTPase activating protein 26 (Predicted). (761 aa) |
| | Tbc1d8 | TBC1 domain family, member 8. (1135 aa) |
| | Ric8a | Synembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. (530 aa) |
| | Ect2 | Epithelial cell-transforming 2. (912 aa) |
| | Iqgap1 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. (1657 aa) |
| | Arhgap10 | Rho GTPase-activating protein 10. (786 aa) |
| | Arhgap8 | Rho GTPase-activating protein 8. (425 aa) |
| | Arhgap29 | Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). (1271 aa) |
| | Rasa2 | Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids. (847 aa) |
| | Tsc2 | Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. (1809 aa) |
| | Adgrb3 | Brain-specific angiogenesis inhibitor 3 (Predicted); Belongs to the G-protein coupled receptor 2 family. (1522 aa) |
| | Myo9a | Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). (2626 aa) |
| | Ralgapa2 | Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. (1869 aa) |
| | Arhgap18 | Rho GTPase activating protein 18 (Predicted), isoform CRA_a. (665 aa) |
| | Smap2 | Small ArfGAP2. (428 aa) |
| | Rapgef6 | Rap guanine nucleotide exchange factor (GEF) 6 (Predicted), isoform CRA_a. (1606 aa) |
| | Rabgap1 | G protein-coupled receptor 21 (Predicted), isoform CRA_a. (1065 aa) |
| | Arhgap25 | Similar to Rho-GTPase-activating protein 25 (Predicted). (648 aa) |
| | Tbc1d4 | TBC1 domain family, member 4. (1309 aa) |
| | Sh3bp1 | SH3 domain-binding protein 1; GTPase activating protein/GAP which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifical [...] (689 aa) |
| | Elmod1 | ELMO domain-containing 1. (334 aa) |
| | Gnb5 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (352 aa) |
| | Jun | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. (334 aa) |
| | Tbc1d2 | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). (924 aa) |
| | Arhgap32 | Rho GTPase-activating protein 32. (2101 aa) |
| | Arhgap11a | Rho GTPase-activating protein 11A. (994 aa) |
| | Ralgapa1 | Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. (1823 aa) |
| | Syde1 | Synapse defective Rho GTPase homolog 1. (735 aa) |
| | Preb | Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. (417 aa) |
| | Tbc1d10a | TBC1 domain family, member 10a. (505 aa) |
| | Tbc1d20 | TBC1 domain family, member 20. (402 aa) |
| | Thy1 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa) |
| | Tbc1d25 | Ornithine aminotransferase-like 1 (Predicted). (688 aa) |
| | Smcr8 | SMCR8-C9orf72 complex subunit. (935 aa) |
| | Dock4 | Dedicator of cytokinesis 4; Belongs to the DOCK family. (1966 aa) |
| | Plcb1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1135 aa) |
| | Sec23a | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa) |
| | Srgap1 | SLIT-ROBO Rho GTPase-activating protein 1. (1085 aa) |
| | Arhgap30 | Similar to RIKEN cDNA 6030405P05 gene (Predicted). (1104 aa) |
| | Lrrk2 | Leucine-rich repeat kinase 2. (2526 aa) |
| | Llgl1 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. (1067 aa) |
| | Rgs18 | Regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity). (235 aa) |
| | Rgs1 | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). (209 aa) |
| | Rgs2 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] (211 aa) |
| | Rgs9 | Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). (677 aa) |
| | Arhgap44 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contract [...] (797 aa) |
| | Flcn | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. (579 aa) |
| | Arhgap31 | Cdc42 GTPase-activating protein (Predicted). (1428 aa) |
| | Rgs4 | Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein. (205 aa) |
| | Rabgap1l | RAB GTPase-activating protein 1-like. (815 aa) |
| | Rasa4 | RAS p21 protein activator 4. (803 aa) |
| | Rasal1 | RAS protein activator like 1 (GAP1 like) (Predicted). (801 aa) |
| | Bcr | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] (1062 aa) |
| | Stard13 | StAR-related lipid transfer domain-containing 13. (1112 aa) |
| | Evi5l | Ecotropic viral integration site 5-like. (501 aa) |
| | F1LR97_RAT | Rho-GAP domain-containing protein. (776 aa) |
| | Sgsm1 | Small G protein-signaling modulator 1. (1093 aa) |
| | Chm | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] (647 aa) |
