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Col9a3 Col9a3 Lamc1 Lamc1 Prelp Prelp Fbln1 Fbln1 Col3a1 Col3a1 Ambn Ambn Col5a2 Col5a2 Col1a1 Col1a1 Dcn Dcn Gp2 Gp2 Comp Comp Col8a2 Col8a2 Matn1 Matn1 Lama2 Lama2 Col1a2 Col1a2 Col19a1 Col19a1 Col15a1 Col15a1 Oit3 Oit3 Lamb2 Lamb2 Hapln4 Hapln4 Impg2 Impg2 Col18a1 Col18a1 Amelx Amelx Col11a2 Col11a2 Col9a2 Col9a2 Lama1 Lama1 Scara3 Scara3 Tectb Tectb Umod Umod Col4a3 Col4a3 Fn1 Fn1 Col24a1 Col24a1 Col9a1 Col9a1 Col4a6 Col4a6 Col17a1 Col17a1 Fbn1 Fbn1 Col4a2 Col4a2 Col4a1 Col4a1 Col28a1 Col28a1 Umodl1 Umodl1 Eln Eln Enam Enam Tecta Tecta Col4a4 Col4a4 Otol1 Otol1 Col8a1 Col8a1 Col4a5 Col4a5 Zp4 Zp4 Col22a1 Col22a1 Zp1 Zp1 Col5a3 Col5a3 Colq Colq Lama3 Lama3 Col12a1 Col12a1 Col10a1 Col10a1 Lama5 Lama5 Col27a1 Col27a1 Emilin1 Emilin1 LOC100909752 LOC100909752 NEWGENE_621351 NEWGENE_621351 Pxdn Pxdn Col2a1 Col2a1 Zp2 Zp2 Col13a1 Col13a1 Lamb1 Lamb1 Lamb3 Lamb3 Zpld1 Zpld1 Col16a1 Col16a1 Col25a1 Col25a1 LOC103693323 LOC103693323 Col11a1 Col11a1 Fbn2 Fbn2 Col6a1 Col6a1 Zp3 Zp3 Col5a1 Col5a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Col9a3Collagen type IX alpha 3 chain. (680 aa)
Lamc1Laminin subunit gamma 1. (1607 aa)
PrelpProlargin; May anchor basement membranes to the underlying connective tissue; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (377 aa)
Fbln1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
Col3a1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). (1463 aa)
AmbnAmeloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. (422 aa)
Col5a2Collagen type V alpha 2 chain. (1494 aa)
Col1a1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1453 aa)
DcnDecorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix. (354 aa)
Gp2Pancreatic secretory granule membrane major glycoprotein GP2. (533 aa)
CompCartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (755 aa)
Col8a2Collagen type VIII alpha 2 chain. (699 aa)
Matn1Matrilin 1, cartilage matrix protein. (498 aa)
Lama2Laminin subunit alpha 2. (3121 aa)
Col1a2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1372 aa)
Col19a1Collagen type XIX alpha 1 chain. (1129 aa)
Col15a1Collagen alpha-1(XV) chain-like. (1312 aa)
Oit3Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development. (545 aa)
Lamb2Laminin subunit beta-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1801 aa)
Hapln4Hyaluronan and proteoglycan link protein 4 (Predicted). (400 aa)
Impg2Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. (1241 aa)
Col18a1Procollagen, type XVIII, alpha 1, isoform CRA_a. (1311 aa)
AmelxAmelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. (219 aa)
Col11a2Procollagen, type XI, alpha 2 (Mapped). (1650 aa)
Col9a2Procollagen, type IX, alpha 2 (Predicted). (688 aa)
Lama1Laminin subunit alpha 1. (3083 aa)
Scara3Scavenger receptor class A, member 3 (Predicted). (606 aa)
TectbTectorin beta (Predicted), isoform CRA_a. (329 aa)
UmodUromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. (644 aa)
Col4a3Collagen type IV alpha 3 chain. (1671 aa)
Fn1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
Col24a1Collagen type XXIV alpha 1 chain. (1352 aa)
Col9a1Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (934 aa)
Col4a6Collagen type IV alpha 6 chain. (1638 aa)
Col17a1Collagen type XVII alpha 1 chain. (1465 aa)
Fbn1Fibrillin 1, isoform CRA_a. (2872 aa)
Col4a2Collagen type IV alpha 2 chain. (1645 aa)
Col4a1Collagen type IV alpha 1 chain. (1669 aa)
Col28a1Collagen type XXVIII alpha 1 chain. (1142 aa)
Umodl1Uromodulin-like 1. (1325 aa)
ElnElastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). (875 aa)
EnamEnamelin (Predicted), isoform CRA_c. (1380 aa)
TectaTectorin alpha. (2155 aa)
Col4a4Collagen type IV alpha 4 chain. (159 aa)
Otol1Otolin 1. (482 aa)
Col8a1Collagen type VIII alpha 1 chain. (744 aa)
Col4a5Collagen type IV alpha 5 chain. (1691 aa)
Zp4Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor; Belongs to the ZP domain family. ZPB subfamily. (545 aa)
Col22a1Collagen type XXII alpha 1 chain. (1613 aa)
Zp1Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida; Belongs to the ZP domain family. ZPB subfamily. (617 aa)
Col5a3Procollagen, type V, alpha 3, isoform CRA_b. (1737 aa)
ColqAcetylcholinesterase collagenic tail peptide; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. (455 aa)
Lama3Uncharacterized protein. (2108 aa)
Col12a1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. (3143 aa)
Col10a1Collagen type X alpha 1 chain. (680 aa)
Lama5Laminin, alpha 5, isoform CRA_a. (3713 aa)
Col27a1Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone. (1855 aa)
Emilin1Elastin microfibril interfacer 1 (Predicted), isoform CRA_b. (900 aa)
LOC100909752Procollagen, type XV, isoform CRA_a. (1345 aa)
NEWGENE_621351Collagen, type I, alpha 2. (1372 aa)
PxdnPeroxidasin. (1475 aa)
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1419 aa)
Zp2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (695 aa)
Col13a1Similar to alpha 1 type XIII collagen isoform 17, isoform CRA_a. (739 aa)
Lamb1Laminin subunit beta 1. (1786 aa)
Lamb3Laminin, beta 3, isoform CRA_a. (1172 aa)
Zpld1Zona pellucida-like domain-containing 1. (313 aa)
Col16a1Collagen type XVI alpha 1 chain. (1618 aa)
Col25a1Collagen type XXV alpha 1 chain. (503 aa)
LOC103693323Collagen alpha-1(XXIII) chain. (532 aa)
Col11a1Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1804 aa)
Fbn2Fibrillin 2. (2590 aa)
Col6a1Collagen type VI alpha 1 chain. (1025 aa)
Zp3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (424 aa)
Col5a1Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). (1840 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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