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Hsd17b14 Hsd17b14 Hsd3b3 Hsd3b3 Hsd11b1 Hsd11b1 Hsd17b10 Hsd17b10 Akr1c13 Akr1c13 Rdh16 Rdh16 Dhrs11 Dhrs11 Akr1c12 Akr1c12 Rdh8 Rdh8 Hsd17b13 Hsd17b13 Hsd3b5 Hsd3b5 Rdh5 Rdh5 Hsd17b4 Hsd17b4 Srd5a3 Srd5a3 Dhrs9 Dhrs9 Nsdhl Nsdhl Sdr42e1 Sdr42e1 Akr1c2 Akr1c2 Akr1c12l1 Akr1c12l1 RGD1564865 RGD1564865 Akr1c1 Akr1c1 Akr1c19 Akr1c19 Hsd17b8 Hsd17b8 Bdh1 Bdh1 Hsd17b11 Hsd17b11 Hsd17b6 Hsd17b6 Hsd17b7 Hsd17b7 Rdh7 Rdh7 Sdr9c7 Sdr9c7 Srd5a2 Srd5a2 Hsd17b12 Hsd17b12 Akr1d1 Akr1d1 Hsd17b2 Hsd17b2 Hsd11b2 Hsd11b2 Srd5a1 Srd5a1 Akr1c3 Akr1c3 Akr1c14 Akr1c14 Hsd17b3 Hsd17b3 Hsd3b7 Hsd3b7 Hsd3b2 Hsd3b2 Hsd17b1 Hsd17b1 Akr1c15 Akr1c15
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Hsd17b14Hydroxysteroid (17-beta) dehydrogenase 14. (270 aa)
Hsd3b3Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3; Belongs to the 3-beta-HSD family. (373 aa)
Hsd11b1Corticosteroid 11-beta-dehydrogenase isozyme 1. (1104 aa)
Hsd17b103-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20- beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structura [...] (261 aa)
Akr1c13Aldo-keto reductase family 1, member C12. (323 aa)
Rdh16Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3- alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
Dhrs11Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
Akr1c12Aldo-keto reductase family 1, member C13. (323 aa)
Rdh8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
Hsd17b1317-beta-hydroxysteroid dehydrogenase 13. (300 aa)
Hsd3b5NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. (373 aa)
Rdh5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
Hsd17b4Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (751 aa)
Srd5a3Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT). (330 aa)
Dhrs9Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
NsdhlSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. (362 aa)
Sdr42e1Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family. (392 aa)
Akr1c2Aldo-keto reductase family 1 member C21; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids (By similarity). (334 aa)
Akr1c12l1Aldo-keto reductase family 1, member C12-like 1. (323 aa)
RGD1564865Similar to 20-alpha-hydroxysteroid dehydrogenase. (295 aa)
Akr1c1Type 5 17beta-hydroxysteroid dehydrogenase. (323 aa)
Akr1c19Similar to aldo-keto reductase family 1, member C12 (Predicted). (323 aa)
Hsd17b8Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
Bdh1D-beta-hydroxybutyrate dehydrogenase, mitochondrial. (344 aa)
Hsd17b11Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (298 aa)
Hsd17b617-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17- beta-diol to androsterone and estradiol to estrone (in vitro). Has 3- alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (345 aa)
Hsd17b73-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. (335 aa)
Rdh7Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
Sdr9c7Short chain dehydrogenase/reductase family 9C, member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
Srd5a23-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). (254 aa)
Hsd17b12Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] (312 aa)
Akr1d1Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). (324 aa)
Hsd17b2Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (381 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. (400 aa)
Srd5a13-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
Akr1c3Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). (323 aa)
Akr1c143-alpha-hydroxysteroid dehydrogenase; Besides being a 3-alpha-hydroxysteroid dehydrogenase, the enzyme can accomplish diverse functions: as quinone reductase, as an aromatic alcohol dehydrogenase, as dihydrodiol dehydrogenase, and as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase. (322 aa)
Hsd17b3Testosterone 17-beta-dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (306 aa)
Hsd3b73 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...] (338 aa)
Hsd3b23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (373 aa)
Hsd17b1Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa)
Akr1c15Aldo-keto reductase family 1 member C15; Catalyzes the NADPH-dependent reduction of a variety of substrates including aromatic and aliphatic aldehydes, quinones, ketones, dicarbonyl compounds and 17-ketosteroids. Catalyzes the NADP(+)-dependent oxidation of aromatic, alicyclic and aliphatic alcohols, and 17beta-hydroxysteroids. To a lesser extent, can also catalyze the reduction of some aldoses and ketoses and the oxidation of some sugar alcohols. In the stomach, lung and colon tissues, mediates the reduction of farnesal and geranylgeranial into farnesol and geranylgeraniol respectivel [...] (324 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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